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• W3120409238 abstract "Background Local administration of growth-inhibiting substances such as paclitaxel or sirolimus could reduce the risk of restenosis. In the drug coated balloon (DCB) technology the coating and the applied dose seem to play a major role. The aim of the present preclinical studies was to investigate the efficacy and safety of a specific DCB with paclitaxel as active ingredient and magnesium stearate as excipient. Methods Evaluation of the coating, drug release and transfer was done ex vivo and in vivo on peripheral arteries. A porcine coronary stent model was chosen to provoke intimal thickening. Conventional uncoated balloons were compared with paclitaxel urea and paclitaxel magnesium stearate coated balloons. QCA and histomorphometry was performed on treated vessels. Three areas of the heart were histologically examined for pathological changes. Results QCA and histomorphometry revealed no differences in baseline data between treatment groups. All DCB groups showed a significant reduction of angiographic and histologic parameters describing neointimal formation 4 weeks after treatment (e.g. mean angiographic late lumen loss all coated 0.31 ± 0.18 mm versus 0.91 ± 0.37 mm in the uncoated balloon group). There were no device-related animal deaths or clinical abnormalities. In spite of very slight-to-slight microscopic findings limited to small arterial vessels in downstream tissue there was no change in left ventricular ejection fraction or angiographic presentation of small side branches of treated arteries. Conclusion Paclitaxel DCB using stearate as excipient show a high efficacy in reducing neointima formation after experimental coronary intervention. No evidence of myocardial damage resulting from distal embolization was found." @default.
• W3120409238 created "2021-01-18" @default.
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• W3120409238 date "2021-05-01" @default.
• W3120409238 modified "2023-09-30" @default.
• W3120409238 title "Efficacy and safety of a magnesium stearate paclitaxel coated balloon catheter in the porcine coronary model" @default.
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• W3120409238 doi "https://doi.org/10.1016/j.ijcard.2020.12.071" @default.
• W3120409238 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33418002" @default.
• W3120409238 hasPublicationYear "2021" @default.
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