FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120421506> ?p ?o ?g. }

• W3120421506 endingPage "460" @default.
• W3120421506 startingPage "447" @default.
• W3120421506 abstract "The thiazide-sensitive sodium-chloride cotransporter (NCC;SLC12A3) is central to sodium and blood pressure regulation. Metabolic syndrome induces NCC upregulation generating sodium-sensitive hypertension in experimental animal models. We tested the role of NCC in sodium sensitivity in hypertensive humans with metabolic syndrome. Conversely, oral potassium induces NCC downregulation producing potassium-induced natriuresis. We determined the time course and magnitude of potassium-induced natriuresis compared with the natriuresis following hydrochlorothiazide (HCTZ) as a reference standard. We studied 19 obese hypertensive humans with metabolic syndrome during 13-day inpatient confinement. We determined sodium sensitivity by change in 24-hour mean systolic pressure by automated monitor from days 5 (low sodium) to 10 (high sodium). We determined NCC activity by standard 50 mg HCTZ sensitivity test (day 11). We determined potassium-induced natriuresis following 35 mmol KCl (day 13). We determined (1) whether NCC activity was greater in sodium-sensitive versus sodium-resistant participants and correlated with sodium sensitivity and (2) time course and magnitude of potassium-induced natriuresis following 35 mmol KCl directly compared with 50 mg HCTZ. NCC activity was not greater in sodium-sensitive versus sodium-resistant humans and did not correlate with sodium sensitivity. Thirty-five-millimoles KCl produced a rapid natriuresis approximately half that of 50 mg HCTZ with a greater kaliuresis. Our investigation tested a key hypothesis regarding NCC activity in human hypertension and characterized potassium-induced natriuresis following 35 mmol KCl compared with 50 mg HCTZ. In obese hypertensive adults with metabolic syndrome ingesting a high-sodium diet, 35 mmol KCl had a net natriuretic effect approximately half that of 50 mg HCTZ." @default.
• W3120421506 created "2021-01-18" @default.
• W3120421506 creator A5039143174 @default.
• W3120421506 creator A5040027692 @default.
• W3120421506 creator A5042593463 @default.
• W3120421506 creator A5045839945 @default.
• W3120421506 creator A5063792338 @default.
• W3120421506 creator A5072425989 @default.
• W3120421506 creator A5090408331 @default.
• W3120421506 date "2021-02-01" @default.
• W3120421506 modified "2023-10-18" @default.
• W3120421506 title "Thiazide-Sensitive NCC (Sodium-Chloride Cotransporter) in Human Metabolic Syndrome" @default.
• W3120421506 cites W1172355299 @default.
• W3120421506 cites W1970486445 @default.
• W3120421506 cites W1978869489 @default.
• W3120421506 cites W1981530557 @default.
• W3120421506 cites W1982498018 @default.
• W3120421506 cites W1985396932 @default.
• W3120421506 cites W1997378647 @default.
• W3120421506 cites W201492019 @default.
• W3120421506 cites W2021017769 @default.
• W3120421506 cites W2021508287 @default.
• W3120421506 cites W2039492547 @default.
• W3120421506 cites W20421448 @default.
• W3120421506 cites W2050875396 @default.
• W3120421506 cites W2066684167 @default.
• W3120421506 cites W2079433948 @default.
• W3120421506 cites W2082268678 @default.
• W3120421506 cites W2083203440 @default.
• W3120421506 cites W2086436922 @default.
• W3120421506 cites W2087144172 @default.
• W3120421506 cites W2104001407 @default.
• W3120421506 cites W2109726655 @default.
• W3120421506 cites W2123573860 @default.
• W3120421506 cites W2142197398 @default.
• W3120421506 cites W2157066558 @default.
• W3120421506 cites W2163780561 @default.
• W3120421506 cites W2166384825 @default.
• W3120421506 cites W2167968191 @default.
• W3120421506 cites W2171650408 @default.
• W3120421506 cites W2327597239 @default.
• W3120421506 cites W2364466751 @default.
• W3120421506 cites W2507439610 @default.
• W3120421506 cites W2570063070 @default.
• W3120421506 cites W2725188415 @default.
• W3120421506 cites W2781698998 @default.
• W3120421506 cites W2809476315 @default.
• W3120421506 cites W2904627891 @default.
• W3120421506 cites W2994427476 @default.
• W3120421506 cites W4252684946 @default.
• W3120421506 doi "https://doi.org/10.1161/hypertensionaha.120.15933" @default.
• W3120421506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33390050" @default.
• W3120421506 hasPublicationYear "2021" @default.
• W3120421506 type Work @default.
• W3120421506 sameAs 3120421506 @default.
• W3120421506 citedByCount "7" @default.
• W3120421506 countsByYear W31204215062022 @default.
• W3120421506 countsByYear W31204215062023 @default.
• W3120421506 crossrefType "journal-article" @default.
• W3120421506 hasAuthorship W3120421506A5039143174 @default.
• W3120421506 hasAuthorship W3120421506A5040027692 @default.
• W3120421506 hasAuthorship W3120421506A5042593463 @default.
• W3120421506 hasAuthorship W3120421506A5045839945 @default.
• W3120421506 hasAuthorship W3120421506A5063792338 @default.
• W3120421506 hasAuthorship W3120421506A5072425989 @default.
• W3120421506 hasAuthorship W3120421506A5090408331 @default.
• W3120421506 hasBestOaLocation W31204215061 @default.
• W3120421506 hasConcept C126322002 @default.
• W3120421506 hasConcept C134018914 @default.
• W3120421506 hasConcept C174459258 @default.
• W3120421506 hasConcept C178790620 @default.
• W3120421506 hasConcept C185592680 @default.
• W3120421506 hasConcept C2780011235 @default.
• W3120421506 hasConcept C2780361556 @default.
• W3120421506 hasConcept C2780437262 @default.
• W3120421506 hasConcept C517785266 @default.
• W3120421506 hasConcept C537181965 @default.
• W3120421506 hasConcept C71924100 @default.
• W3120421506 hasConcept C84393581 @default.
• W3120421506 hasConceptScore W3120421506C126322002 @default.
• W3120421506 hasConceptScore W3120421506C134018914 @default.
• W3120421506 hasConceptScore W3120421506C174459258 @default.
• W3120421506 hasConceptScore W3120421506C178790620 @default.
• W3120421506 hasConceptScore W3120421506C185592680 @default.
• W3120421506 hasConceptScore W3120421506C2780011235 @default.
• W3120421506 hasConceptScore W3120421506C2780361556 @default.
• W3120421506 hasConceptScore W3120421506C2780437262 @default.
• W3120421506 hasConceptScore W3120421506C517785266 @default.
• W3120421506 hasConceptScore W3120421506C537181965 @default.
• W3120421506 hasConceptScore W3120421506C71924100 @default.
• W3120421506 hasConceptScore W3120421506C84393581 @default.
• W3120421506 hasIssue "2" @default.
• W3120421506 hasLocation W31204215061 @default.
• W3120421506 hasOpenAccess W3120421506 @default.
• W3120421506 hasPrimaryLocation W31204215061 @default.
• W3120421506 hasRelatedWork W1998267900 @default.
• W3120421506 hasRelatedWork W2043883559 @default.
• W3120421506 hasRelatedWork W2086673831 @default.

• next