Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120423114> ?p ?o ?g. }
- W3120423114 abstract "Replication-dependent histone mRNAs are the only cellular mRNAs that are not polyadenylated, ending in a stemloop instead of a polyA tail, and are normally regulated coordinately with DNA replication. Stemloop-binding protein (SLBP) binds the 3' end of histone mRNA, and is required for processing and translation. During Drosophila oogenesis, large amounts of histone mRNAs and proteins are deposited in the developing oocyte. The maternally deposited histone mRNA is synthesized in stage 10B oocytes after the nurse cells complete endoreduplication. We report that in wild-type stage 10B oocytes, the histone locus bodies (HLBs), formed on the histone genes, produce histone mRNAs in the absence of phosphorylation of Mxc, which is normally required for histone gene expression in S-phase cells. Two mutants of SLBP, one with reduced expression and another with a 10-amino-acid deletion, fail to deposit sufficient histone mRNA in the oocyte, and do not transcribe the histone genes in stage 10B. Mutations in a putative SLBP nuclear localization sequence overlapping the deletion phenocopy the deletion. We conclude that a high concentration of SLBP in the nucleus of stage 10B oocytes is essential for histone gene transcription.This article has an associated First Person interview with the first author of the paper." @default.
- W3120423114 created "2021-01-18" @default.
- W3120423114 creator A5020991475 @default.
- W3120423114 creator A5047703823 @default.
- W3120423114 creator A5054882422 @default.
- W3120423114 date "2021-02-01" @default.
- W3120423114 modified "2023-10-17" @default.
- W3120423114 title "A region of SLBP outside the mRNA-processing domain is essential for deposition of histone mRNA into the <i>Drosophila</i> egg" @default.
- W3120423114 cites W1571632059 @default.
- W3120423114 cites W1966536060 @default.
- W3120423114 cites W1971645068 @default.
- W3120423114 cites W1972392744 @default.
- W3120423114 cites W1992294145 @default.
- W3120423114 cites W2000706669 @default.
- W3120423114 cites W2003847336 @default.
- W3120423114 cites W2004356580 @default.
- W3120423114 cites W2017581149 @default.
- W3120423114 cites W2036074921 @default.
- W3120423114 cites W2036086371 @default.
- W3120423114 cites W2038443908 @default.
- W3120423114 cites W2041905891 @default.
- W3120423114 cites W2044774520 @default.
- W3120423114 cites W2045978868 @default.
- W3120423114 cites W2046965780 @default.
- W3120423114 cites W2047040065 @default.
- W3120423114 cites W2065530211 @default.
- W3120423114 cites W2089843919 @default.
- W3120423114 cites W2097117853 @default.
- W3120423114 cites W2097904707 @default.
- W3120423114 cites W2100247897 @default.
- W3120423114 cites W2103587834 @default.
- W3120423114 cites W2104099845 @default.
- W3120423114 cites W2104582907 @default.
- W3120423114 cites W2104798106 @default.
- W3120423114 cites W2108889064 @default.
- W3120423114 cites W2109572773 @default.
- W3120423114 cites W2111005893 @default.
- W3120423114 cites W2121506620 @default.
- W3120423114 cites W2123452714 @default.
- W3120423114 cites W2129104583 @default.
- W3120423114 cites W2132456634 @default.
- W3120423114 cites W2136739479 @default.
- W3120423114 cites W2138993899 @default.
- W3120423114 cites W2139631353 @default.
- W3120423114 cites W2142534168 @default.
- W3120423114 cites W2145206558 @default.
- W3120423114 cites W2150536557 @default.
- W3120423114 cites W2151677871 @default.
- W3120423114 cites W2151872074 @default.
- W3120423114 cites W2152807182 @default.
- W3120423114 cites W2153681451 @default.
- W3120423114 cites W2158651132 @default.
- W3120423114 cites W2160130765 @default.
- W3120423114 cites W2182989927 @default.
- W3120423114 cites W2258247685 @default.
- W3120423114 cites W2259170714 @default.
- W3120423114 cites W2419244230 @default.
- W3120423114 cites W2570943423 @default.
- W3120423114 cites W2597110051 @default.
- W3120423114 cites W2752583760 @default.
- W3120423114 cites W2797604131 @default.
- W3120423114 cites W2942145769 @default.
- W3120423114 cites W2965923968 @default.
- W3120423114 cites W3035906587 @default.
- W3120423114 cites W4241316979 @default.
- W3120423114 cites W4297673475 @default.
- W3120423114 doi "https://doi.org/10.1242/jcs.251728" @default.
- W3120423114 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7888719" @default.
- W3120423114 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33408246" @default.
- W3120423114 hasPublicationYear "2021" @default.
- W3120423114 type Work @default.
- W3120423114 sameAs 3120423114 @default.
- W3120423114 citedByCount "2" @default.
- W3120423114 countsByYear W31204231142021 @default.
- W3120423114 countsByYear W31204231142022 @default.
- W3120423114 crossrefType "journal-article" @default.
- W3120423114 hasAuthorship W3120423114A5020991475 @default.
- W3120423114 hasAuthorship W3120423114A5047703823 @default.
- W3120423114 hasAuthorship W3120423114A5054882422 @default.
- W3120423114 hasBestOaLocation W31204231141 @default.
- W3120423114 hasConcept C101152365 @default.
- W3120423114 hasConcept C104317684 @default.
- W3120423114 hasConcept C105580179 @default.
- W3120423114 hasConcept C142575336 @default.
- W3120423114 hasConcept C150425827 @default.
- W3120423114 hasConcept C153911025 @default.
- W3120423114 hasConcept C2779085176 @default.
- W3120423114 hasConcept C45946802 @default.
- W3120423114 hasConcept C54355233 @default.
- W3120423114 hasConcept C56428682 @default.
- W3120423114 hasConcept C64927066 @default.
- W3120423114 hasConcept C86803240 @default.
- W3120423114 hasConcept C95444343 @default.
- W3120423114 hasConceptScore W3120423114C101152365 @default.
- W3120423114 hasConceptScore W3120423114C104317684 @default.
- W3120423114 hasConceptScore W3120423114C105580179 @default.
- W3120423114 hasConceptScore W3120423114C142575336 @default.
- W3120423114 hasConceptScore W3120423114C150425827 @default.
- W3120423114 hasConceptScore W3120423114C153911025 @default.
- W3120423114 hasConceptScore W3120423114C2779085176 @default.