FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120441063> ?p ?o ?g. }

• W3120441063 endingPage "544" @default.
• W3120441063 startingPage "539" @default.
• W3120441063 abstract "Although high-dose glucocorticoids are effective in suppressing active inflammation of Takayasu arteritis (TAK), many patients experience relapse during tapering of glucocorticoids. Recently, the interleukin-6 receptor antibody, tocilizumab (TCZ), was reported to be effective for steroid-resistant TAK. However, there are no objective ways of diagnosing TAK recurrence because TCZ suppresses inflammatory biomarkers.To investigate the efficacy of TCZ at 1-year follow-up and of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography for detection of recurrence of inflammation during TCZ treatment.We treated 19 patients with refractory TAK with TCZ. TCZ was discontinued in 2 cases because of side effects. Abatement of arteritis symptoms along with reduction of glucocorticoid dosage was achieved in 12 patients, resulting in a remission induction rate of 70.6%. The dosage of glucocorticoid was reduced from 16.1 ± 10.2 mg to 3.8 ± 1.7 mg at 1 year (p<0.001) in these patients. In the remaining 5 patients, glucocorticoid tapering led to exacerbation of symptoms and glucocorticoid dose had to be increased. FDG-PET scan results closely matched clinical course in all 5 patients with recurrence even during TCZ treatment, while the scan was negative for the remaining 12 patients.TCZ injection provides robust steroid-sparing effect and improvement of inflammation without significant adverse effects. Recurrence of inflammation can be detected by FDG-PET even during TCZ treatment." @default.
• W3120441063 created "2021-01-18" @default.
• W3120441063 creator A5001616072 @default.
• W3120441063 creator A5019042345 @default.
• W3120441063 creator A5034642477 @default.
• W3120441063 creator A5044383005 @default.
• W3120441063 date "2021-05-01" @default.
• W3120441063 modified "2023-09-27" @default.
• W3120441063 title "Evaluation of tocilizumab for intractable Takayasu arteritis and 18F-fluorodeoxyglucose-positron emission tomography for detecting inflammation under tocilizumab treatment" @default.
• W3120441063 cites W12298886 @default.
• W3120441063 cites W1979109757 @default.
• W3120441063 cites W1984510109 @default.
• W3120441063 cites W1984555696 @default.
• W3120441063 cites W2024606804 @default.
• W3120441063 cites W2037921505 @default.
• W3120441063 cites W2044258895 @default.
• W3120441063 cites W2066865753 @default.
• W3120441063 cites W2085402016 @default.
• W3120441063 cites W2132452388 @default.
• W3120441063 cites W2143660712 @default.
• W3120441063 cites W2167298427 @default.
• W3120441063 cites W2169058648 @default.
• W3120441063 cites W2221164950 @default.
• W3120441063 cites W2326862192 @default.
• W3120441063 cites W2330394253 @default.
• W3120441063 cites W2335361706 @default.
• W3120441063 cites W2512606343 @default.
• W3120441063 cites W2563505684 @default.
• W3120441063 cites W2773804470 @default.
• W3120441063 cites W2774617616 @default.
• W3120441063 cites W2801325762 @default.
• W3120441063 cites W2910710924 @default.
• W3120441063 cites W2999068470 @default.
• W3120441063 cites W3000229260 @default.
• W3120441063 cites W4238228430 @default.
• W3120441063 doi "https://doi.org/10.1016/j.jjcc.2020.12.011" @default.
• W3120441063 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33451862" @default.
• W3120441063 hasPublicationYear "2021" @default.
• W3120441063 type Work @default.
• W3120441063 sameAs 3120441063 @default.
• W3120441063 citedByCount "12" @default.
• W3120441063 countsByYear W31204410632021 @default.
• W3120441063 countsByYear W31204410632022 @default.
• W3120441063 countsByYear W31204410632023 @default.
• W3120441063 crossrefType "journal-article" @default.
• W3120441063 hasAuthorship W3120441063A5001616072 @default.
• W3120441063 hasAuthorship W3120441063A5019042345 @default.
• W3120441063 hasAuthorship W3120441063A5034642477 @default.
• W3120441063 hasAuthorship W3120441063A5044383005 @default.
• W3120441063 hasBestOaLocation W31204410631 @default.
• W3120441063 hasConcept C114138010 @default.
• W3120441063 hasConcept C121684516 @default.
• W3120441063 hasConcept C126322002 @default.
• W3120441063 hasConcept C126838900 @default.
• W3120441063 hasConcept C197934379 @default.
• W3120441063 hasConcept C2775842073 @default.
• W3120441063 hasConcept C2776015282 @default.
• W3120441063 hasConcept C2776712624 @default.
• W3120441063 hasConcept C2776914184 @default.
• W3120441063 hasConcept C2777014857 @default.
• W3120441063 hasConcept C2777178219 @default.
• W3120441063 hasConcept C2777575956 @default.
• W3120441063 hasConcept C2779134260 @default.
• W3120441063 hasConcept C2780841215 @default.
• W3120441063 hasConcept C2781343717 @default.
• W3120441063 hasConcept C2989005 @default.
• W3120441063 hasConcept C41008148 @default.
• W3120441063 hasConcept C71924100 @default.
• W3120441063 hasConcept C90924648 @default.
• W3120441063 hasConceptScore W3120441063C114138010 @default.
• W3120441063 hasConceptScore W3120441063C121684516 @default.
• W3120441063 hasConceptScore W3120441063C126322002 @default.
• W3120441063 hasConceptScore W3120441063C126838900 @default.
• W3120441063 hasConceptScore W3120441063C197934379 @default.
• W3120441063 hasConceptScore W3120441063C2775842073 @default.
• W3120441063 hasConceptScore W3120441063C2776015282 @default.
• W3120441063 hasConceptScore W3120441063C2776712624 @default.
• W3120441063 hasConceptScore W3120441063C2776914184 @default.
• W3120441063 hasConceptScore W3120441063C2777014857 @default.
• W3120441063 hasConceptScore W3120441063C2777178219 @default.
• W3120441063 hasConceptScore W3120441063C2777575956 @default.
• W3120441063 hasConceptScore W3120441063C2779134260 @default.
• W3120441063 hasConceptScore W3120441063C2780841215 @default.
• W3120441063 hasConceptScore W3120441063C2781343717 @default.
• W3120441063 hasConceptScore W3120441063C2989005 @default.
• W3120441063 hasConceptScore W3120441063C41008148 @default.
• W3120441063 hasConceptScore W3120441063C71924100 @default.
• W3120441063 hasConceptScore W3120441063C90924648 @default.
• W3120441063 hasIssue "5" @default.
• W3120441063 hasLocation W31204410631 @default.
• W3120441063 hasLocation W31204410632 @default.
• W3120441063 hasOpenAccess W3120441063 @default.
• W3120441063 hasPrimaryLocation W31204410631 @default.
• W3120441063 hasRelatedWork W1968260519 @default.
• W3120441063 hasRelatedWork W2400830200 @default.
• W3120441063 hasRelatedWork W2753708235 @default.
• W3120441063 hasRelatedWork W2792261031 @default.
• W3120441063 hasRelatedWork W2802777075 @default.

• next