Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120442694> ?p ?o ?g. }
- W3120442694 abstract "Alcohol is one of the most commonly abused intoxicants with 1 in 6 adults at risk for alcohol use disorder (AUD) in the United States. As such, animal models have been extensively investigated with rodent AUD models being the most widely studied. However, inherent anatomical and physiological differences between rodents and humans pose a number of limitations in studying the complex nature of human AUD. For example, rodents differ from humans in that rodents metabolize alcohol rapidly and do not innately demonstrate voluntary alcohol consumption. Comparatively, pigs exhibit similar patterns observed in human AUD including voluntary alcohol consumption and intoxication behaviors, which are instrumental in establishing a more representative AUD model that could in turn delineate the risk factors involved in the development of this disorder. Pigs and humans also share anatomical similarities in the two major target organs of alcohol- the brain and liver. Pigs possess gyrencephalic brains with comparable cerebral white matter volumes to humans, thus enabling more representative evaluations of susceptibility and neural tissue damage in response to AUD. Furthermore, similarities in the liver result in a comparable rate of alcohol elimination as humans, thus enabling a more accurate extrapolation of dosage and intoxication level to humans. A porcine model of AUD possesses great translational potential that can significantly advance our current understanding of the complex development and continuance of AUD in humans." @default.
- W3120442694 created "2021-01-18" @default.
- W3120442694 creator A5009556011 @default.
- W3120442694 creator A5023884583 @default.
- W3120442694 creator A5043787614 @default.
- W3120442694 date "2021-01-07" @default.
- W3120442694 modified "2023-10-14" @default.
- W3120442694 title "Alcohol Induced Brain and Liver Damage: Advantages of a Porcine Alcohol Use Disorder Model" @default.
- W3120442694 cites W107475310 @default.
- W3120442694 cites W1139269317 @default.
- W3120442694 cites W1511100745 @default.
- W3120442694 cites W1570708643 @default.
- W3120442694 cites W1594015135 @default.
- W3120442694 cites W1841749037 @default.
- W3120442694 cites W1918713759 @default.
- W3120442694 cites W1922179103 @default.
- W3120442694 cites W1965429322 @default.
- W3120442694 cites W1967729138 @default.
- W3120442694 cites W1969928171 @default.
- W3120442694 cites W1969949618 @default.
- W3120442694 cites W1971033557 @default.
- W3120442694 cites W1972039452 @default.
- W3120442694 cites W1973367631 @default.
- W3120442694 cites W1975458997 @default.
- W3120442694 cites W1977007975 @default.
- W3120442694 cites W1977148261 @default.
- W3120442694 cites W1978941262 @default.
- W3120442694 cites W1979505617 @default.
- W3120442694 cites W1980727604 @default.
- W3120442694 cites W1981600556 @default.
- W3120442694 cites W1981818046 @default.
- W3120442694 cites W1983768473 @default.
- W3120442694 cites W1983906797 @default.
- W3120442694 cites W1985926085 @default.
- W3120442694 cites W1989171198 @default.
- W3120442694 cites W1993691356 @default.
- W3120442694 cites W1995838863 @default.
- W3120442694 cites W1997400309 @default.
- W3120442694 cites W2000796770 @default.
- W3120442694 cites W2003775449 @default.
- W3120442694 cites W2004984114 @default.
- W3120442694 cites W2005509461 @default.
- W3120442694 cites W2005820090 @default.
- W3120442694 cites W2007469070 @default.
- W3120442694 cites W2009346831 @default.
- W3120442694 cites W2011044541 @default.
- W3120442694 cites W2011432151 @default.
- W3120442694 cites W2011981060 @default.
- W3120442694 cites W2016437478 @default.
- W3120442694 cites W2018445772 @default.
- W3120442694 cites W2018639131 @default.
- W3120442694 cites W2020435939 @default.
- W3120442694 cites W2024911712 @default.
- W3120442694 cites W2025412939 @default.
- W3120442694 cites W2028496027 @default.
- W3120442694 cites W2029682444 @default.
- W3120442694 cites W2030338901 @default.
- W3120442694 cites W2031020377 @default.
- W3120442694 cites W2033227860 @default.
- W3120442694 cites W2035380257 @default.
- W3120442694 cites W2035513563 @default.
- W3120442694 cites W2038459771 @default.
- W3120442694 cites W2039004255 @default.
- W3120442694 cites W2039178669 @default.
- W3120442694 cites W2040006431 @default.
- W3120442694 cites W2043757605 @default.
- W3120442694 cites W2045710756 @default.
- W3120442694 cites W2050166523 @default.
- W3120442694 cites W2051263615 @default.
- W3120442694 cites W2056755823 @default.
- W3120442694 cites W2059714773 @default.
- W3120442694 cites W2059742041 @default.
- W3120442694 cites W2060375736 @default.
- W3120442694 cites W2061593054 @default.
- W3120442694 cites W2062725718 @default.
- W3120442694 cites W2062902372 @default.
- W3120442694 cites W2065121422 @default.
- W3120442694 cites W2068412840 @default.
- W3120442694 cites W2068717879 @default.
- W3120442694 cites W2070647828 @default.
- W3120442694 cites W2071197145 @default.
- W3120442694 cites W2071769613 @default.
- W3120442694 cites W2072263717 @default.
- W3120442694 cites W2073265436 @default.
- W3120442694 cites W2073681731 @default.
- W3120442694 cites W2074858378 @default.
- W3120442694 cites W2076325336 @default.
- W3120442694 cites W2085421010 @default.
- W3120442694 cites W2086275553 @default.
- W3120442694 cites W2086562792 @default.
- W3120442694 cites W2088762260 @default.
- W3120442694 cites W2089007738 @default.
- W3120442694 cites W2092302827 @default.
- W3120442694 cites W2092933199 @default.
- W3120442694 cites W2093830143 @default.
- W3120442694 cites W2094909334 @default.
- W3120442694 cites W2100705061 @default.
- W3120442694 cites W2105670621 @default.
- W3120442694 cites W2105952206 @default.
- W3120442694 cites W2109061387 @default.