Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120465547> ?p ?o ?g. }
- W3120465547 endingPage "104811" @default.
- W3120465547 startingPage "104811" @default.
- W3120465547 abstract "Sulfobutyl ether derivative of β-cyclodextrin, cross-linked in the presence of antibacterial drug moxifloxacin, forms polymeric nanoparticles (50–150 nm in diameter), with highly efficient (up to 85%) encapsulation of the drug. Cyclodextrins (CyDs) have been known for their ability to accommodate a wide range of organic molecules in their inner cavity, leading to «guest-host» inclusion complexes. Here, we show that in the case of highly cross-linked complex a substantial part of moxifloxacin molecules can be captured by the polymer's network (i.e. encapsulated in the growing 3D structure) rather than absorbed by the CyD's inner cavity. This is accompanied by dramatic changes in moxifloxacin's release kinetics profile: depending on pH, 30–100% of the drug is released from the polymer network within a week. Whereas in the case of moxifloxacin absorption on pre-synthesized CyD polymer matrix, 50% release normally occurs within hours. In vitro studies on Escherichia coli demonstrate that the moxifloxacin in highly cross-linked nanoparticle can preserve over 50% of antibacterial activity for at least 7 days, whereas the same amount of free moxifloxacin, as well as its «guest-host» complex with CyD, is inactive at this time point. The nanoparticles' ability to adhere to the bacterial cell wall may contribute to the higher activity of the smaller amount of the drug, emphasizing the potential relevance of this approach for the development of new pharmaceutical formulations." @default.
- W3120465547 created "2021-01-18" @default.
- W3120465547 creator A5000221964 @default.
- W3120465547 creator A5021629196 @default.
- W3120465547 creator A5029380605 @default.
- W3120465547 creator A5031358809 @default.
- W3120465547 creator A5032077149 @default.
- W3120465547 creator A5045691279 @default.
- W3120465547 date "2021-02-01" @default.
- W3120465547 modified "2023-10-01" @default.
- W3120465547 title "The formation of quasi-regular polymeric network of cross-linked sulfobutyl ether derivative of β-cyclodextrin synthesized with moxifloxacin as a template" @default.
- W3120465547 cites W1895129045 @default.
- W3120465547 cites W1906015552 @default.
- W3120465547 cites W1969330428 @default.
- W3120465547 cites W1969373285 @default.
- W3120465547 cites W1977798951 @default.
- W3120465547 cites W1984863587 @default.
- W3120465547 cites W1989315749 @default.
- W3120465547 cites W2011398813 @default.
- W3120465547 cites W2011603124 @default.
- W3120465547 cites W2014832032 @default.
- W3120465547 cites W2018946538 @default.
- W3120465547 cites W2025446482 @default.
- W3120465547 cites W2046498709 @default.
- W3120465547 cites W2049514441 @default.
- W3120465547 cites W2054661534 @default.
- W3120465547 cites W2062803116 @default.
- W3120465547 cites W2063018229 @default.
- W3120465547 cites W2071496956 @default.
- W3120465547 cites W2084673355 @default.
- W3120465547 cites W2090950664 @default.
- W3120465547 cites W2093409459 @default.
- W3120465547 cites W2099906325 @default.
- W3120465547 cites W2119567467 @default.
- W3120465547 cites W2119927970 @default.
- W3120465547 cites W2129039800 @default.
- W3120465547 cites W2149888549 @default.
- W3120465547 cites W2236863537 @default.
- W3120465547 cites W2252628274 @default.
- W3120465547 cites W2285180923 @default.
- W3120465547 cites W2530853164 @default.
- W3120465547 cites W2728378947 @default.
- W3120465547 cites W2753671398 @default.
- W3120465547 cites W2755846005 @default.
- W3120465547 cites W2797419003 @default.
- W3120465547 cites W2807552826 @default.
- W3120465547 cites W2883227232 @default.
- W3120465547 cites W2910599081 @default.
- W3120465547 cites W2920330980 @default.
- W3120465547 cites W2924043138 @default.
- W3120465547 cites W2950223301 @default.
- W3120465547 cites W3093727009 @default.
- W3120465547 doi "https://doi.org/10.1016/j.reactfunctpolym.2021.104811" @default.
- W3120465547 hasPublicationYear "2021" @default.
- W3120465547 type Work @default.
- W3120465547 sameAs 3120465547 @default.
- W3120465547 citedByCount "14" @default.
- W3120465547 countsByYear W31204655472021 @default.
- W3120465547 countsByYear W31204655472022 @default.
- W3120465547 countsByYear W31204655472023 @default.
- W3120465547 crossrefType "journal-article" @default.
- W3120465547 hasAuthorship W3120465547A5000221964 @default.
- W3120465547 hasAuthorship W3120465547A5021629196 @default.
- W3120465547 hasAuthorship W3120465547A5029380605 @default.
- W3120465547 hasAuthorship W3120465547A5031358809 @default.
- W3120465547 hasAuthorship W3120465547A5032077149 @default.
- W3120465547 hasAuthorship W3120465547A5045691279 @default.
- W3120465547 hasConcept C13965031 @default.
- W3120465547 hasConcept C155672457 @default.
- W3120465547 hasConcept C171250308 @default.
- W3120465547 hasConcept C178790620 @default.
- W3120465547 hasConcept C185592680 @default.
- W3120465547 hasConcept C192562407 @default.
- W3120465547 hasConcept C21951064 @default.
- W3120465547 hasConcept C2778836808 @default.
- W3120465547 hasConcept C2779433975 @default.
- W3120465547 hasConcept C2780104969 @default.
- W3120465547 hasConcept C32909587 @default.
- W3120465547 hasConcept C501593827 @default.
- W3120465547 hasConcept C521977710 @default.
- W3120465547 hasConcept C523546767 @default.
- W3120465547 hasConcept C54355233 @default.
- W3120465547 hasConcept C55493867 @default.
- W3120465547 hasConcept C71240020 @default.
- W3120465547 hasConcept C86803240 @default.
- W3120465547 hasConceptScore W3120465547C13965031 @default.
- W3120465547 hasConceptScore W3120465547C155672457 @default.
- W3120465547 hasConceptScore W3120465547C171250308 @default.
- W3120465547 hasConceptScore W3120465547C178790620 @default.
- W3120465547 hasConceptScore W3120465547C185592680 @default.
- W3120465547 hasConceptScore W3120465547C192562407 @default.
- W3120465547 hasConceptScore W3120465547C21951064 @default.
- W3120465547 hasConceptScore W3120465547C2778836808 @default.
- W3120465547 hasConceptScore W3120465547C2779433975 @default.
- W3120465547 hasConceptScore W3120465547C2780104969 @default.
- W3120465547 hasConceptScore W3120465547C32909587 @default.
- W3120465547 hasConceptScore W3120465547C501593827 @default.
- W3120465547 hasConceptScore W3120465547C521977710 @default.