Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120494428> ?p ?o ?g. }
- W3120494428 abstract "Ca2+ alternans (Ca-Alts) are alternating beat-to-beat changes in the amplitude of Ca2+ transients that frequently occur during tachycardia, ischemia, or hypothermia that can lead to sudden cardiac death. Ca-Alts appear to result from a variation in the amount of Ca2+ released from the sarcoplasmic reticulum (SR) between two consecutive heartbeats. This variable Ca2+ release has been attributed to the alternation of the action potential duration, delay in the recovery from inactivation of RYR Ca2+ release channel (RYR2), or an incomplete Ca2+ refilling of the SR. In all three cases, the RYR2 mobilizes less Ca2+ from the SR in an alternating manner, thereby generating an alternating profile of the Ca2+ transients. We used a new experimental approach, fluorescence local field optical mapping (FLOM), to record at the epicardial layer of an intact heart with subcellular resolution. In conjunction with a local cold finger, a series of images were recorded within an area where the local cooling induced a temperature gradient. Ca-Alts were larger in colder regions and occurred without changes in action potential duration. Analysis of the change in the enthalpy and Q10 of several kinetic processes defining intracellular Ca2+ dynamics indicated that the effects of temperature change on the relaxation of intracellular Ca2+ transients involved both passive and active mechanisms. The steep temperature dependency of Ca-Alts during tachycardia suggests Ca-Alts are generated by insufficient SERCA-mediated Ca2+ uptake into the SR. We found that Ca-Alts are heavily dependent on intra-SR Ca2+ and can be promoted through partial pharmacologic inhibition of SERCA2a. Finally, the FLOM experimental approach has the potential to help us understand how arrhythmogenesis correlates with the spatial distribution of metabolically impaired myocytes along the myocardium." @default.
- W3120494428 created "2021-01-18" @default.
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- W3120494428 date "2021-01-07" @default.
- W3120494428 modified "2023-10-13" @default.
- W3120494428 title "Thermal modulation of epicardial Ca2+ dynamics uncovers molecular mechanisms of Ca2+ alternans" @default.
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- W3120494428 doi "https://doi.org/10.1085/jgp.202012568" @default.
- W3120494428 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7797898" @default.
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- W3120494428 hasPublicationYear "2021" @default.
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