Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120523022> ?p ?o ?g. }
- W3120523022 endingPage "895" @default.
- W3120523022 startingPage "886" @default.
- W3120523022 abstract "Abstract Enhanced apoptosis of cardiomyocytes in suffering overloaded saturated fatty acids (SFAs) can result in myocardial infarction and cardiac dysfunction. The function of vascular endothelial growth factor (VEGF) in cardiomyocyte protection was not clearly described. To investigate the preservative effects of VEGF sensitization on ceramide-mediated programmed cell death of cardiomyocytes, palmitate-induced injury in H9c2 cells was established as an in vitro model. Results revealed that 0.5 mM palmitate application effectively led to debased viability and activated apoptotic factors. A significant time-dependent relation between PAL and cardiomyocyte injury was observed. The apoptosis rate was increased greatly after 16 h of treatment with 0.5 mM PAL. In addition, cell viability was restored by VEGF overexpression during treatment with 0.5 mM PAL. Reduced apoptosis rate and expression of caspase 3, Bax, and NF-κB p65 were observed in this process, while boosted Bcl-2, p-JNK/JNK expression and activity of caspase 3 were checked. However, p-ERK/ERK levels did not exhibit a significant change. These findings indicated the protective effects of VEGF in confronting the ceramide-induced cardiomyocyte apoptosis, and would devote therapeutic targets for cardiovascular safeguard in dealing with fatty acid stress." @default.
- W3120523022 created "2021-01-18" @default.
- W3120523022 creator A5006354151 @default.
- W3120523022 creator A5014297531 @default.
- W3120523022 creator A5015640756 @default.
- W3120523022 creator A5023472837 @default.
- W3120523022 creator A5030419231 @default.
- W3120523022 creator A5063987255 @default.
- W3120523022 date "2021-10-01" @default.
- W3120523022 modified "2023-10-18" @default.
- W3120523022 title "Vascular endothelial growth factor ameliorated palmitate-induced cardiomyocyte injury via JNK pathway" @default.
- W3120523022 cites W1546237323 @default.
- W3120523022 cites W1972440163 @default.
- W3120523022 cites W1973539438 @default.
- W3120523022 cites W1976221241 @default.
- W3120523022 cites W1976829005 @default.
- W3120523022 cites W2015424171 @default.
- W3120523022 cites W2032234589 @default.
- W3120523022 cites W2040116142 @default.
- W3120523022 cites W2077129920 @default.
- W3120523022 cites W2079796426 @default.
- W3120523022 cites W2088883749 @default.
- W3120523022 cites W2091942844 @default.
- W3120523022 cites W2113783769 @default.
- W3120523022 cites W2116287353 @default.
- W3120523022 cites W2131335242 @default.
- W3120523022 cites W2138981871 @default.
- W3120523022 cites W2148608806 @default.
- W3120523022 cites W2157548490 @default.
- W3120523022 cites W2165574517 @default.
- W3120523022 cites W2314441511 @default.
- W3120523022 cites W2342643431 @default.
- W3120523022 cites W2473343559 @default.
- W3120523022 cites W2572840791 @default.
- W3120523022 cites W2584159992 @default.
- W3120523022 cites W2748278949 @default.
- W3120523022 cites W2876726071 @default.
- W3120523022 cites W2893553693 @default.
- W3120523022 cites W2915285292 @default.
- W3120523022 cites W2917743074 @default.
- W3120523022 cites W2945960888 @default.
- W3120523022 cites W2980342819 @default.
- W3120523022 cites W2990306379 @default.
- W3120523022 cites W2990819945 @default.
- W3120523022 cites W3003253515 @default.
- W3120523022 cites W3003299879 @default.
- W3120523022 cites W3006082663 @default.
- W3120523022 cites W3016979633 @default.
- W3120523022 cites W3038657437 @default.
- W3120523022 cites W3042390316 @default.
- W3120523022 cites W3043823012 @default.
- W3120523022 cites W3090425244 @default.
- W3120523022 cites W3093411994 @default.
- W3120523022 cites W3093601476 @default.
- W3120523022 doi "https://doi.org/10.1007/s11626-021-00616-z" @default.
- W3120523022 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34791626" @default.
- W3120523022 hasPublicationYear "2021" @default.
- W3120523022 type Work @default.
- W3120523022 sameAs 3120523022 @default.
- W3120523022 citedByCount "2" @default.
- W3120523022 countsByYear W31205230222022 @default.
- W3120523022 countsByYear W31205230222023 @default.
- W3120523022 crossrefType "journal-article" @default.
- W3120523022 hasAuthorship W3120523022A5006354151 @default.
- W3120523022 hasAuthorship W3120523022A5014297531 @default.
- W3120523022 hasAuthorship W3120523022A5015640756 @default.
- W3120523022 hasAuthorship W3120523022A5023472837 @default.
- W3120523022 hasAuthorship W3120523022A5030419231 @default.
- W3120523022 hasAuthorship W3120523022A5063987255 @default.
- W3120523022 hasBestOaLocation W31205230221 @default.
- W3120523022 hasConcept C167734588 @default.
- W3120523022 hasConcept C185592680 @default.
- W3120523022 hasConcept C190283241 @default.
- W3120523022 hasConcept C2777025900 @default.
- W3120523022 hasConcept C2777851122 @default.
- W3120523022 hasConcept C502942594 @default.
- W3120523022 hasConcept C53227056 @default.
- W3120523022 hasConcept C55493867 @default.
- W3120523022 hasConcept C57074206 @default.
- W3120523022 hasConcept C62478195 @default.
- W3120523022 hasConcept C86803240 @default.
- W3120523022 hasConcept C95444343 @default.
- W3120523022 hasConcept C98274493 @default.
- W3120523022 hasConceptScore W3120523022C167734588 @default.
- W3120523022 hasConceptScore W3120523022C185592680 @default.
- W3120523022 hasConceptScore W3120523022C190283241 @default.
- W3120523022 hasConceptScore W3120523022C2777025900 @default.
- W3120523022 hasConceptScore W3120523022C2777851122 @default.
- W3120523022 hasConceptScore W3120523022C502942594 @default.
- W3120523022 hasConceptScore W3120523022C53227056 @default.
- W3120523022 hasConceptScore W3120523022C55493867 @default.
- W3120523022 hasConceptScore W3120523022C57074206 @default.
- W3120523022 hasConceptScore W3120523022C62478195 @default.
- W3120523022 hasConceptScore W3120523022C86803240 @default.
- W3120523022 hasConceptScore W3120523022C95444343 @default.
- W3120523022 hasConceptScore W3120523022C98274493 @default.
- W3120523022 hasIssue "9" @default.
- W3120523022 hasLocation W31205230221 @default.