FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120532369> ?p ?o ?g. }

• W3120532369 endingPage "119031" @default.
• W3120532369 startingPage "119031" @default.
• W3120532369 abstract "Cadmium (Cd) is a prevalent environmental contaminant that incurs deleterious health effects, including testicular impairment. Sitagliptin, a selective dipeptidyl peptidase-4 (DPP-4) inhibitor, has demonstrated marked cardio-, hepato-, and reno-protective actions, however, its impact on Cd-triggered testicular dysfunction has not been formerly investigated. Hence, the present study aimed to explore the probable beneficial impact of sitagliptin against Cd-evoked testicular impairment which may add to its potential clinical utility. The underlying mechanisms pertaining to the balance between testicular autophagy and apoptosis were explored, including the AMPK/mTOR and Nrf2/HO-1 pathways. The testicular tissues were examined using histopathology, immunohistochemistry, Western blotting, and ELISA. Sitagliptin (10 mg/kg/day, by gavage) was administered for 4 consecutive weeks. Sitagliptin attenuated the testicular impairment via improvement of the relative testicular weight, sperm count/motility, sperm abnormalities, and serum testosterone. Additionally, sitagliptin counteracted Cd-induced histologic aberrations/disrupted spermatogenesis. Interestingly, sitagliptin augmented the defective autophagy as demonstrated by upregulating Beclin 1 protein expression and lowering p62 SQSTM1 protein accumulation. These effects were mediated via the activation of testicular AMPK/mTOR pathway as proven by increasing p-AMPK (Ser485, Ser491)/total AMPK and diminishing p-mTOR (Ser2448)/total mTOR protein expression. Additionally, sitagliptin suppressed the testicular apoptotic events via downregulating Bax and upregulating Bcl-2 protein expression. In tandem, sitagliptin suppressed the oxidative stress through lowering lipid peroxides and activating Nrf2/HO-1 pathway via upregulating the protein expression of Nrf2, and the downstream effectors HO-1 and GPx. Sitagliptin attenuated Cd-induced testicular injury via boosting the autophagy/apoptosis ratio through activation of AMPK/mTOR and Nrf2/HO-1 pathways." @default.
• W3120532369 created "2021-01-18" @default.
• W3120532369 creator A5003133457 @default.
• W3120532369 creator A5013603363 @default.
• W3120532369 creator A5028997514 @default.
• W3120532369 creator A5073630519 @default.
• W3120532369 creator A5081264481 @default.
• W3120532369 date "2021-03-01" @default.
• W3120532369 modified "2023-10-16" @default.
• W3120532369 title "Activation of autophagy by sitagliptin attenuates cadmium-induced testicular impairment in rats: Targeting AMPK/mTOR and Nrf2/HO-1 pathways" @default.
• W3120532369 cites W1590457525 @default.
• W3120532369 cites W1964801668 @default.
• W3120532369 cites W1989428356 @default.
• W3120532369 cites W1990618316 @default.
• W3120532369 cites W1994033421 @default.
• W3120532369 cites W1999704268 @default.
• W3120532369 cites W2001616373 @default.
• W3120532369 cites W2001675597 @default.
• W3120532369 cites W2002061608 @default.
• W3120532369 cites W2006645386 @default.
• W3120532369 cites W2014674361 @default.
• W3120532369 cites W2023598683 @default.
• W3120532369 cites W2040435722 @default.
• W3120532369 cites W2074690413 @default.
• W3120532369 cites W2080660042 @default.
• W3120532369 cites W2102354517 @default.
• W3120532369 cites W2121019653 @default.
• W3120532369 cites W2134073425 @default.
• W3120532369 cites W2142830692 @default.
• W3120532369 cites W2531164886 @default.
• W3120532369 cites W2553194449 @default.
• W3120532369 cites W2555428382 @default.
• W3120532369 cites W2598265081 @default.
• W3120532369 cites W2598555903 @default.
• W3120532369 cites W2735557749 @default.
• W3120532369 cites W2735592915 @default.
• W3120532369 cites W2740198235 @default.
• W3120532369 cites W2761503357 @default.
• W3120532369 cites W2767263655 @default.
• W3120532369 cites W2770171557 @default.
• W3120532369 cites W2773925677 @default.
• W3120532369 cites W2774306605 @default.
• W3120532369 cites W2781891708 @default.
• W3120532369 cites W2792117328 @default.
• W3120532369 cites W2795845448 @default.
• W3120532369 cites W2802375479 @default.
• W3120532369 cites W2888238518 @default.
• W3120532369 cites W2897115298 @default.
• W3120532369 cites W2898343276 @default.
• W3120532369 cites W2904330298 @default.
• W3120532369 cites W2905562298 @default.
• W3120532369 cites W2905575900 @default.
• W3120532369 cites W2910494915 @default.
• W3120532369 cites W2947282728 @default.
• W3120532369 cites W2954336747 @default.
• W3120532369 cites W2974231197 @default.
• W3120532369 cites W2982891174 @default.
• W3120532369 cites W3024742332 @default.
• W3120532369 cites W3027890954 @default.
• W3120532369 cites W3081602884 @default.
• W3120532369 cites W3083339695 @default.
• W3120532369 cites W569142017 @default.
• W3120532369 doi "https://doi.org/10.1016/j.lfs.2021.119031" @default.
• W3120532369 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33453244" @default.
• W3120532369 hasPublicationYear "2021" @default.
• W3120532369 type Work @default.
• W3120532369 sameAs 3120532369 @default.
• W3120532369 citedByCount "25" @default.
• W3120532369 countsByYear W31205323692021 @default.
• W3120532369 countsByYear W31205323692022 @default.
• W3120532369 countsByYear W31205323692023 @default.
• W3120532369 crossrefType "journal-article" @default.
• W3120532369 hasAuthorship W3120532369A5003133457 @default.
• W3120532369 hasAuthorship W3120532369A5013603363 @default.
• W3120532369 hasAuthorship W3120532369A5028997514 @default.
• W3120532369 hasAuthorship W3120532369A5073630519 @default.
• W3120532369 hasAuthorship W3120532369A5081264481 @default.
• W3120532369 hasConcept C126322002 @default.
• W3120532369 hasConcept C134018914 @default.
• W3120532369 hasConcept C184235292 @default.
• W3120532369 hasConcept C185592680 @default.
• W3120532369 hasConcept C190283241 @default.
• W3120532369 hasConcept C203522944 @default.
• W3120532369 hasConcept C2779284873 @default.
• W3120532369 hasConcept C2780124434 @default.
• W3120532369 hasConcept C2910068830 @default.
• W3120532369 hasConcept C55493867 @default.
• W3120532369 hasConcept C555293320 @default.
• W3120532369 hasConcept C71924100 @default.
• W3120532369 hasConcept C86554907 @default.
• W3120532369 hasConcept C97029542 @default.
• W3120532369 hasConceptScore W3120532369C126322002 @default.
• W3120532369 hasConceptScore W3120532369C134018914 @default.
• W3120532369 hasConceptScore W3120532369C184235292 @default.
• W3120532369 hasConceptScore W3120532369C185592680 @default.
• W3120532369 hasConceptScore W3120532369C190283241 @default.
• W3120532369 hasConceptScore W3120532369C203522944 @default.
• W3120532369 hasConceptScore W3120532369C2779284873 @default.

• next