Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120585537> ?p ?o ?g. }
- W3120585537 abstract "The field of gene therapy has made considerable progress over the past several years. Adeno-associated virus (AAV) vectors have emerged as promising and attractive tools for in vivo gene therapy. Despite the recent clinical successes achieved with recombinant AAVs (rAAVs) for therapeutics, host immune responses against the vector and transgene product have been observed in numerous preclinical and clinical studies. These outcomes have hampered the advancement of AAV gene therapies, preventing them from becoming fully viable and safe medicines. The human immune system is multidimensional and complex. Both the innate and adaptive arms of the immune system seem to play a concerted role in the response against rAAVs. While most efforts have been focused on the role of adaptive immunity and developing ways to overcome it, the innate immune system has also been found to have a critical function. Innate immunity not only mediates the initial response to the vector, but also primes the adaptive immune system to launch a more deleterious attack against the foreign vector. This Review highlights what is known about innate immune responses against rAAVs and discusses potential strategies to circumvent these pathways." @default.
- W3120585537 created "2021-01-18" @default.
- W3120585537 creator A5009470292 @default.
- W3120585537 creator A5013010624 @default.
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- W3120585537 creator A5046186975 @default.
- W3120585537 creator A5067369102 @default.
- W3120585537 creator A5088115504 @default.
- W3120585537 date "2021-01-04" @default.
- W3120585537 modified "2023-10-01" @default.
- W3120585537 title "Overcoming innate immune barriers that impede AAV gene therapy vectors" @default.
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