Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120590280> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W3120590280 endingPage "76" @default.
- W3120590280 startingPage "69" @default.
- W3120590280 abstract "PURPOSE: Bladder outlet obstruction (BOO) causes storage and voiding dysfunction in the lower urinary tract. We investigated the expression of transient receptor potential cation channel subfamily M member 8 (TRPM8) to evaluate the relationship between TRPM8 expression and overactive bladder (OAB) in a rat model of BOO. METHODS: Fifty female Sprague-Dawley rats were divided into 4 groups; normal (n=10), normal-menthol (n=10), BOO (n=15), BOO-menthol (n=15). After 3 weeks, cystometry was performed by infusing physiological saline and menthol (3 mM) into the bladder at a slow infusion rate. The histological changes and expression of TRPM8 in the bladder were investigated by Masson's trichrome staining, immunofluorescence and reverse transcription-polymerase chain reaction. RESULTS: Cystometry showed that the intercontraction interval (ICI; 428.2±23.4 vs. 880.4±51.2, P<0.001), micturition pressure (MP; 25.7±1.01 vs. 71.80±3.01, P<0.001), and threshold pressure (2.9±0.25 vs. 9.2±1.58, P<0.01) were significantly increased in BOO rats. The bladder wall was significantly dilated compared with the control. Detrusor muscle hypertrophy and a thick mucosa layer were observed in BOO bladder. After menthol treatment, ICIs were decreased and MPs were increased in the menthol treatment groups. TRPM8-positive cells and mRNA were predominantly increased in the bladder and dorsal root ganglia of all groups compared with the normal group. CONCLUSIONS: Increased bladder wall thickness and proportion of collagen probably affect voiding dysfunction. Furthermore, an increase of TRPM8 expression in BOO may induce entry of Ca(2+) from the extracellular space or stores. The increase of Ca(2+) probably causes contraction of smooth muscle in BOO. However, OAB symptoms were not observed after menthol treatment although the expression of TRPM8 was abundant in the bladder epithelium after menthol treatment. Although OAB in BOO models may be caused by complex pathways, regulation of TRPM8 presents possibilities for OAB treatment." @default.
- W3120590280 created "2021-01-18" @default.
- W3120590280 creator A5024749992 @default.
- W3120590280 creator A5041179704 @default.
- W3120590280 creator A5048173084 @default.
- W3120590280 creator A5081042987 @default.
- W3120590280 creator A5085003874 @default.
- W3120590280 creator A5087073139 @default.
- W3120590280 creator A5090877776 @default.
- W3120590280 date "2012-01-01" @default.
- W3120590280 modified "2023-09-23" @default.
- W3120590280 title "Function of the Cold Receptor (TRPM8) Associated with Voiding Dysfunction in Bladder Outlet Obstruction in Rats." @default.
- W3120590280 hasPublicationYear "2012" @default.
- W3120590280 type Work @default.
- W3120590280 sameAs 3120590280 @default.
- W3120590280 citedByCount "0" @default.
- W3120590280 crossrefType "journal-article" @default.
- W3120590280 hasAuthorship W3120590280A5024749992 @default.
- W3120590280 hasAuthorship W3120590280A5041179704 @default.
- W3120590280 hasAuthorship W3120590280A5048173084 @default.
- W3120590280 hasAuthorship W3120590280A5081042987 @default.
- W3120590280 hasAuthorship W3120590280A5085003874 @default.
- W3120590280 hasAuthorship W3120590280A5087073139 @default.
- W3120590280 hasAuthorship W3120590280A5090877776 @default.
- W3120590280 hasConcept C121608353 @default.
- W3120590280 hasConcept C126322002 @default.
- W3120590280 hasConcept C126894567 @default.
- W3120590280 hasConcept C134018914 @default.
- W3120590280 hasConcept C142724271 @default.
- W3120590280 hasConcept C155164980 @default.
- W3120590280 hasConcept C160145004 @default.
- W3120590280 hasConcept C163146387 @default.
- W3120590280 hasConcept C170493617 @default.
- W3120590280 hasConcept C175768497 @default.
- W3120590280 hasConcept C204787440 @default.
- W3120590280 hasConcept C2776235491 @default.
- W3120590280 hasConcept C2778941218 @default.
- W3120590280 hasConcept C2779478474 @default.
- W3120590280 hasConcept C2779762690 @default.
- W3120590280 hasConcept C2780070792 @default.
- W3120590280 hasConcept C2780080261 @default.
- W3120590280 hasConcept C2780616540 @default.
- W3120590280 hasConcept C71924100 @default.
- W3120590280 hasConcept C77411442 @default.
- W3120590280 hasConceptScore W3120590280C121608353 @default.
- W3120590280 hasConceptScore W3120590280C126322002 @default.
- W3120590280 hasConceptScore W3120590280C126894567 @default.
- W3120590280 hasConceptScore W3120590280C134018914 @default.
- W3120590280 hasConceptScore W3120590280C142724271 @default.
- W3120590280 hasConceptScore W3120590280C155164980 @default.
- W3120590280 hasConceptScore W3120590280C160145004 @default.
- W3120590280 hasConceptScore W3120590280C163146387 @default.
- W3120590280 hasConceptScore W3120590280C170493617 @default.
- W3120590280 hasConceptScore W3120590280C175768497 @default.
- W3120590280 hasConceptScore W3120590280C204787440 @default.
- W3120590280 hasConceptScore W3120590280C2776235491 @default.
- W3120590280 hasConceptScore W3120590280C2778941218 @default.
- W3120590280 hasConceptScore W3120590280C2779478474 @default.
- W3120590280 hasConceptScore W3120590280C2779762690 @default.
- W3120590280 hasConceptScore W3120590280C2780070792 @default.
- W3120590280 hasConceptScore W3120590280C2780080261 @default.
- W3120590280 hasConceptScore W3120590280C2780616540 @default.
- W3120590280 hasConceptScore W3120590280C71924100 @default.
- W3120590280 hasConceptScore W3120590280C77411442 @default.
- W3120590280 hasIssue "2" @default.
- W3120590280 hasLocation W31205902801 @default.
- W3120590280 hasOpenAccess W3120590280 @default.
- W3120590280 hasPrimaryLocation W31205902801 @default.
- W3120590280 hasRelatedWork W1517917574 @default.
- W3120590280 hasRelatedWork W1979110267 @default.
- W3120590280 hasRelatedWork W1983387947 @default.
- W3120590280 hasRelatedWork W1996247078 @default.
- W3120590280 hasRelatedWork W2001831364 @default.
- W3120590280 hasRelatedWork W2030560353 @default.
- W3120590280 hasRelatedWork W2033485430 @default.
- W3120590280 hasRelatedWork W2045657058 @default.
- W3120590280 hasRelatedWork W2052986896 @default.
- W3120590280 hasRelatedWork W2074807617 @default.
- W3120590280 hasRelatedWork W2076818171 @default.
- W3120590280 hasRelatedWork W2085898792 @default.
- W3120590280 hasRelatedWork W2094909668 @default.
- W3120590280 hasRelatedWork W216804313 @default.
- W3120590280 hasRelatedWork W2276560621 @default.
- W3120590280 hasRelatedWork W2356827119 @default.
- W3120590280 hasRelatedWork W2779616741 @default.
- W3120590280 hasRelatedWork W2969195663 @default.
- W3120590280 hasRelatedWork W3119770505 @default.
- W3120590280 hasRelatedWork W2782318757 @default.
- W3120590280 hasVolume "16" @default.
- W3120590280 isParatext "false" @default.
- W3120590280 isRetracted "false" @default.
- W3120590280 magId "3120590280" @default.
- W3120590280 workType "article" @default.