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- W3120638928 startingPage "53" @default.
- W3120638928 abstract "Aberrant factors associated with fibrinolysis and thrombosis are found in many cancer patients, which can promote metastasis and are associated with poor prognosis. The relationship between tumor-associated fibrinolysis and thrombosis is poorly understood in pancreatic cancer. This review provides a brief highlight of existing studies that the fibrinolysis and coagulation systems were activated in pancreatic cancer patients, along with aberrant high concentrations of tissue plasminogen activator (t-PA), urine plasminogen activator (u-PA), D-dimer, fibrinogen, or platelets. These factors cooperate with each other, propelling tumor cell shedding, localization, adhesion to distant metastasis. The relationship between thrombosis or fibrinolysis and cancer immune escape is also investigated. In addition, the potential prevention and therapy strategies of pancreatic cancer targeting factors in fibrinolysis and coagulation systems are also been discussed, in which we highlight two effective agents aspirin and low-molecular weight heparin (LMWH). Summarily, this review provides new directions for the research and treatment of pancreatic cancer." @default.
- W3120638928 created "2021-01-18" @default.
- W3120638928 creator A5005577232 @default.
- W3120638928 creator A5027761006 @default.
- W3120638928 creator A5052907619 @default.
- W3120638928 creator A5074966676 @default.
- W3120638928 date "2021-01-01" @default.
- W3120638928 modified "2023-10-16" @default.
- W3120638928 title "Aberrant Factors of Fibrinolysis and Coagulation in Pancreatic Cancer" @default.
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