Matches in SemOpenAlex for { <https://semopenalex.org/work/W312065173> ?p ?o ?g. }
- W312065173 endingPage "93" @default.
- W312065173 startingPage "83" @default.
- W312065173 abstract "Reactions of 6,6″-dimethyl-2,2′:6′,2″-terpyridine ligand L and VX3 (X = Cl, Br) in aerobic conditions result in formation of two new mononuclear coordination compounds: [VOLCl2] 1 and [VO2L]2Br2·3H2O 2, as revealed by means of single crystal X-ray analyses. The final form of vanadium complex in the solid state, either oxido (V(IV)) or dioxido (V(V)), was found to be contingent on the size of applied halide, as demonstrated by direct V–X interaction for small chloride (1) or ionic interaction for bulkier bromide (2). Depending on crystallization conditions, [VOLCl2] 1 forms polymorphic green or yellow crystals from MeCN or MeOH respectively. Compounds were characterized by elemental analysis, spectrometric (ESI-MS), electrochemical, (cyclic voltammetry) spectroscopic methods (UV–VIS, FTIR, EPR) and evaluated in terms of biological properties. Their cytotoxic activity was investigated in MTT assay and supported by absorption titration spectra suggesting the possible mechanism of action going through intercalative binding mode. On the basis of high binding constants Kbind = 4.4 × 105 M−1 (1) and Kbind = 1.0 × 106 M−1 (2) the relationship between structure of the complex and DNA interaction could be established, highlighting indirect impact of counterions on the final structure formation and thus biological activity. Flow cytometry analysis further confirmed the DNA binding based mechanism of action. What is more, compounds 1 and 2 are first reported cytotoxically active vanadium systems with 2,2′:6′,2″-terpyridine scaffolded family towards T47D cell line." @default.
- W312065173 created "2016-06-24" @default.
- W312065173 creator A5006230670 @default.
- W312065173 creator A5015642350 @default.
- W312065173 creator A5018075201 @default.
- W312065173 creator A5021009741 @default.
- W312065173 creator A5022624462 @default.
- W312065173 creator A5042340251 @default.
- W312065173 creator A5044113240 @default.
- W312065173 creator A5044803909 @default.
- W312065173 creator A5073296589 @default.
- W312065173 creator A5074302300 @default.
- W312065173 date "2015-09-01" @default.
- W312065173 modified "2023-10-03" @default.
- W312065173 title "New vanadium complexes with 6,6″-dimethyl-2,2′:6′,2″-terpyridine in terms of structure and biological properties" @default.
- W312065173 cites W1539866419 @default.
- W312065173 cites W1964916603 @default.
- W312065173 cites W1968441560 @default.
- W312065173 cites W1970151463 @default.
- W312065173 cites W1970401962 @default.
- W312065173 cites W1975846173 @default.
- W312065173 cites W1977513040 @default.
- W312065173 cites W1977898858 @default.
- W312065173 cites W1980199536 @default.
- W312065173 cites W1983009271 @default.
- W312065173 cites W1984210744 @default.
- W312065173 cites W1984869811 @default.
- W312065173 cites W1985233650 @default.
- W312065173 cites W1985578053 @default.
- W312065173 cites W1986062458 @default.
- W312065173 cites W1987494745 @default.
- W312065173 cites W1999873117 @default.
- W312065173 cites W2000050735 @default.
- W312065173 cites W2004045475 @default.
- W312065173 cites W2004221220 @default.
- W312065173 cites W2008224234 @default.
- W312065173 cites W2026086345 @default.
- W312065173 cites W2028796175 @default.
- W312065173 cites W2031374220 @default.
- W312065173 cites W2032851574 @default.
- W312065173 cites W2034610667 @default.
- W312065173 cites W2039669384 @default.
- W312065173 cites W2040076544 @default.
- W312065173 cites W2044507521 @default.
- W312065173 cites W2056083348 @default.
- W312065173 cites W2062449031 @default.
- W312065173 cites W2063720007 @default.
- W312065173 cites W2065485865 @default.
- W312065173 cites W2070549379 @default.
- W312065173 cites W2080172344 @default.
- W312065173 cites W2080182825 @default.
- W312065173 cites W2086024362 @default.
- W312065173 cites W2086997985 @default.
- W312065173 cites W2091845354 @default.
- W312065173 cites W2092060387 @default.
- W312065173 cites W2095049230 @default.
- W312065173 cites W2095395284 @default.
- W312065173 cites W2095563515 @default.
- W312065173 cites W2102547716 @default.
- W312065173 cites W2111692492 @default.
- W312065173 cites W2125093214 @default.
- W312065173 cites W2137996531 @default.
- W312065173 cites W2147016808 @default.
- W312065173 cites W2154570751 @default.
- W312065173 cites W2157380241 @default.
- W312065173 cites W2163915517 @default.
- W312065173 cites W2167754330 @default.
- W312065173 cites W2319372657 @default.
- W312065173 cites W2322412587 @default.
- W312065173 cites W2324613566 @default.
- W312065173 cites W2325128343 @default.
- W312065173 cites W2327599482 @default.
- W312065173 cites W2069794497 @default.
- W312065173 doi "https://doi.org/10.1016/j.poly.2015.05.021" @default.
- W312065173 hasPublicationYear "2015" @default.
- W312065173 type Work @default.
- W312065173 sameAs 312065173 @default.
- W312065173 citedByCount "19" @default.
- W312065173 countsByYear W3120651732016 @default.
- W312065173 countsByYear W3120651732017 @default.
- W312065173 countsByYear W3120651732018 @default.
- W312065173 countsByYear W3120651732019 @default.
- W312065173 countsByYear W3120651732020 @default.
- W312065173 countsByYear W3120651732021 @default.
- W312065173 countsByYear W3120651732022 @default.
- W312065173 countsByYear W3120651732023 @default.
- W312065173 crossrefType "journal-article" @default.
- W312065173 hasAuthorship W312065173A5006230670 @default.
- W312065173 hasAuthorship W312065173A5015642350 @default.
- W312065173 hasAuthorship W312065173A5018075201 @default.
- W312065173 hasAuthorship W312065173A5021009741 @default.
- W312065173 hasAuthorship W312065173A5022624462 @default.
- W312065173 hasAuthorship W312065173A5042340251 @default.
- W312065173 hasAuthorship W312065173A5044113240 @default.
- W312065173 hasAuthorship W312065173A5044803909 @default.
- W312065173 hasAuthorship W312065173A5073296589 @default.
- W312065173 hasAuthorship W312065173A5074302300 @default.
- W312065173 hasConcept C116569031 @default.