Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120671320> ?p ?o ?g. }
Showing items 1 to 83 of
83
with 100 items per page.
- W3120671320 abstract "Abstract Background: this study aimed to identify potential biomarkers for the screening and therapeutic monitoring of sepsis in canine pyometra and correlations with clinical parameters. Samples were collected from a total of 90 dogs with pyometra and 26 healthy female controls. The levels of inflammatory biomarkers and clinical parameters recorded in the dogs with pyometra at presentation were compared with those in the healthy subjects. In addition, consecutive samples from 22 dogs with surgically corrected pyometra and nine healthy controls, were compared before and after ovariohysterectomy. Results: significant leucocytosis, anaemia, hyperglobulinaemia, hypoalbuminaemia, and elevated activities of the alanine aminotransferase and alkaline phosphatase (ALP) enzymes, were observed in the dogs with pyometra at presentation. Moreover, the concentrations of acute inflammatory proteins of C-reactive protein (CRP) and serum amyloid A (SAA), as well as those of cell-free DNA (cfDNA), were significantly higher in the dogs with pyometra. cfDNA was the most sensitive biomarker for systemic inflammation, based on the receiver operating characteristic curve analysis (area under the curve = 0.959). After surgical removal of the inflamed uterus, leucocyte and red blood cell counts, cholesterol, albumin, globulin levels, and the ALP activity significantly decreased. The levels of inflammatory parameters such as interleukin-6 (IL-6), high-mobility group box 1 (HMGB1), and procalcitonin (PCT) also significantly decreased after surgical treatment. Conclusions: these findings indicate that cfDNA, CRP, and SAA have the potential to be used as clinical biomarkers for screening canine sepsis, whereas PCT, IL-6, and HMGB1 may be useful biomarkers for the therapeutic monitoring of canine sepsis." @default.
- W3120671320 created "2021-01-18" @default.
- W3120671320 creator A5038122610 @default.
- W3120671320 creator A5042852035 @default.
- W3120671320 creator A5053272212 @default.
- W3120671320 creator A5058639575 @default.
- W3120671320 creator A5063275461 @default.
- W3120671320 creator A5063762312 @default.
- W3120671320 creator A5086862078 @default.
- W3120671320 creator A5091487446 @default.
- W3120671320 date "2021-01-13" @default.
- W3120671320 modified "2023-09-26" @default.
- W3120671320 title "Comparison of Clinical and Inflammatory Parameters in Dogs with Pyometra Before and After Ovariohysterectomy" @default.
- W3120671320 doi "https://doi.org/10.21203/rs.3.rs-143024/v1" @default.
- W3120671320 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8451705" @default.
- W3120671320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34602731" @default.
- W3120671320 hasPublicationYear "2021" @default.
- W3120671320 type Work @default.
- W3120671320 sameAs 3120671320 @default.
- W3120671320 citedByCount "4" @default.
- W3120671320 countsByYear W31206713202022 @default.
- W3120671320 countsByYear W31206713202023 @default.
- W3120671320 crossrefType "posted-content" @default.
- W3120671320 hasAuthorship W3120671320A5038122610 @default.
- W3120671320 hasAuthorship W3120671320A5042852035 @default.
- W3120671320 hasAuthorship W3120671320A5053272212 @default.
- W3120671320 hasAuthorship W3120671320A5058639575 @default.
- W3120671320 hasAuthorship W3120671320A5063275461 @default.
- W3120671320 hasAuthorship W3120671320A5063762312 @default.
- W3120671320 hasAuthorship W3120671320A5086862078 @default.
- W3120671320 hasAuthorship W3120671320A5091487446 @default.
- W3120671320 hasBestOaLocation W31206713201 @default.
- W3120671320 hasConcept C10936531 @default.
- W3120671320 hasConcept C126322002 @default.
- W3120671320 hasConcept C160160445 @default.
- W3120671320 hasConcept C181199279 @default.
- W3120671320 hasConcept C203014093 @default.
- W3120671320 hasConcept C2776125364 @default.
- W3120671320 hasConcept C2776914184 @default.
- W3120671320 hasConcept C2778384902 @default.
- W3120671320 hasConcept C2779066055 @default.
- W3120671320 hasConcept C2780861324 @default.
- W3120671320 hasConcept C2781197716 @default.
- W3120671320 hasConcept C55359608 @default.
- W3120671320 hasConcept C55493867 @default.
- W3120671320 hasConcept C57194454 @default.
- W3120671320 hasConcept C71924100 @default.
- W3120671320 hasConcept C86803240 @default.
- W3120671320 hasConcept C90924648 @default.
- W3120671320 hasConceptScore W3120671320C10936531 @default.
- W3120671320 hasConceptScore W3120671320C126322002 @default.
- W3120671320 hasConceptScore W3120671320C160160445 @default.
- W3120671320 hasConceptScore W3120671320C181199279 @default.
- W3120671320 hasConceptScore W3120671320C203014093 @default.
- W3120671320 hasConceptScore W3120671320C2776125364 @default.
- W3120671320 hasConceptScore W3120671320C2776914184 @default.
- W3120671320 hasConceptScore W3120671320C2778384902 @default.
- W3120671320 hasConceptScore W3120671320C2779066055 @default.
- W3120671320 hasConceptScore W3120671320C2780861324 @default.
- W3120671320 hasConceptScore W3120671320C2781197716 @default.
- W3120671320 hasConceptScore W3120671320C55359608 @default.
- W3120671320 hasConceptScore W3120671320C55493867 @default.
- W3120671320 hasConceptScore W3120671320C57194454 @default.
- W3120671320 hasConceptScore W3120671320C71924100 @default.
- W3120671320 hasConceptScore W3120671320C86803240 @default.
- W3120671320 hasConceptScore W3120671320C90924648 @default.
- W3120671320 hasLocation W31206713201 @default.
- W3120671320 hasOpenAccess W3120671320 @default.
- W3120671320 hasPrimaryLocation W31206713201 @default.
- W3120671320 hasRelatedWork W1979772664 @default.
- W3120671320 hasRelatedWork W2093855183 @default.
- W3120671320 hasRelatedWork W2157677201 @default.
- W3120671320 hasRelatedWork W3023244877 @default.
- W3120671320 hasRelatedWork W3025590681 @default.
- W3120671320 hasRelatedWork W3088905972 @default.
- W3120671320 hasRelatedWork W3133559158 @default.
- W3120671320 hasRelatedWork W4284885747 @default.
- W3120671320 hasRelatedWork W4285138001 @default.
- W3120671320 hasRelatedWork W4310066134 @default.
- W3120671320 isParatext "false" @default.
- W3120671320 isRetracted "false" @default.
- W3120671320 magId "3120671320" @default.
- W3120671320 workType "article" @default.