FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120674329> ?p ?o ?g. }

• W3120674329 endingPage "113185" @default.
• W3120674329 startingPage "113185" @default.
• W3120674329 abstract "In this work, we found that 14-deoxy-11,12-didehydroandrographolide (2), a derivative of andrographolide (AP, 1), had greatly reduced cytotoxicity compared with AP and exhibited moderate anti-osteoclastogenesis activity. Thirty compounds were synthesized by introducing anti-osteoporosis chemotypes at C-19 of 2. Six of them exhibited stronger inhibition of osteoclastogenesis than AP. Of note, compound 12g displayed the most potent activity with IC50 value of 0.35 μM. The expression levels of osteoclast-specific genes such as TRAcP, CTSK, NFATc1, and MMP-9 were also decreased by 12g treatment. Furthermore, Western blot and immunofluorescence analyses demonstrated that compound 12g inhibited osteoclast differentiation through downregulation of RANKL-induced NF-κB signaling pathway. In an ovariectomized (OVX) female mice model, compound 12g significantly ameliorated bone loss. Therefore, compound 12g exhibited promising in vivo efficacy and low toxicity, indicating its therapeutic potential for the treatment of osteoporosis." @default.
• W3120674329 created "2021-01-18" @default.
• W3120674329 creator A5005573082 @default.
• W3120674329 creator A5012176782 @default.
• W3120674329 creator A5014866676 @default.
• W3120674329 creator A5038906848 @default.
• W3120674329 creator A5057426807 @default.
• W3120674329 creator A5057651958 @default.
• W3120674329 creator A5070005587 @default.
• W3120674329 creator A5075479739 @default.
• W3120674329 creator A5084058732 @default.
• W3120674329 creator A5086271283 @default.
• W3120674329 date "2021-03-01" @default.
• W3120674329 modified "2023-10-01" @default.
• W3120674329 title "Synthesis and evaluation of andrographolide derivatives as potent anti-osteoporosis agents in vitro and in vivo" @default.
• W3120674329 cites W1551051666 @default.
• W3120674329 cites W1966437151 @default.
• W3120674329 cites W1967502057 @default.
• W3120674329 cites W1978049004 @default.
• W3120674329 cites W1990092707 @default.
• W3120674329 cites W1993110501 @default.
• W3120674329 cites W2003035047 @default.
• W3120674329 cites W2004263474 @default.
• W3120674329 cites W2012192486 @default.
• W3120674329 cites W2034238658 @default.
• W3120674329 cites W2043577758 @default.
• W3120674329 cites W2075209403 @default.
• W3120674329 cites W2086044645 @default.
• W3120674329 cites W2093252878 @default.
• W3120674329 cites W2094974840 @default.
• W3120674329 cites W2123346255 @default.
• W3120674329 cites W2141824025 @default.
• W3120674329 cites W2176336088 @default.
• W3120674329 cites W2435512142 @default.
• W3120674329 cites W2558441120 @default.
• W3120674329 cites W2598548669 @default.
• W3120674329 cites W2736612854 @default.
• W3120674329 cites W2777385048 @default.
• W3120674329 cites W2791177186 @default.
• W3120674329 cites W2886171169 @default.
• W3120674329 cites W2899053070 @default.
• W3120674329 cites W2908768015 @default.
• W3120674329 cites W2935236512 @default.
• W3120674329 cites W2945706117 @default.
• W3120674329 cites W2947095786 @default.
• W3120674329 cites W2949556776 @default.
• W3120674329 cites W2983916342 @default.
• W3120674329 cites W2990618060 @default.
• W3120674329 cites W2995735301 @default.
• W3120674329 cites W3010840228 @default.
• W3120674329 cites W3097231047 @default.
• W3120674329 doi "https://doi.org/10.1016/j.ejmech.2021.113185" @default.
• W3120674329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33485256" @default.
• W3120674329 hasPublicationYear "2021" @default.
• W3120674329 type Work @default.
• W3120674329 sameAs 3120674329 @default.
• W3120674329 citedByCount "7" @default.
• W3120674329 countsByYear W31206743292021 @default.
• W3120674329 countsByYear W31206743292022 @default.
• W3120674329 countsByYear W31206743292023 @default.
• W3120674329 crossrefType "journal-article" @default.
• W3120674329 hasAuthorship W3120674329A5005573082 @default.
• W3120674329 hasAuthorship W3120674329A5012176782 @default.
• W3120674329 hasAuthorship W3120674329A5014866676 @default.
• W3120674329 hasAuthorship W3120674329A5038906848 @default.
• W3120674329 hasAuthorship W3120674329A5057426807 @default.
• W3120674329 hasAuthorship W3120674329A5057651958 @default.
• W3120674329 hasAuthorship W3120674329A5070005587 @default.
• W3120674329 hasAuthorship W3120674329A5075479739 @default.
• W3120674329 hasAuthorship W3120674329A5084058732 @default.
• W3120674329 hasAuthorship W3120674329A5086271283 @default.
• W3120674329 hasConcept C104317684 @default.
• W3120674329 hasConcept C109316439 @default.
• W3120674329 hasConcept C126322002 @default.
• W3120674329 hasConcept C127561419 @default.
• W3120674329 hasConcept C150903083 @default.
• W3120674329 hasConcept C170493617 @default.
• W3120674329 hasConcept C185592680 @default.
• W3120674329 hasConcept C202751555 @default.
• W3120674329 hasConcept C207001950 @default.
• W3120674329 hasConcept C2776033226 @default.
• W3120674329 hasConcept C2776415932 @default.
• W3120674329 hasConcept C2776541429 @default.
• W3120674329 hasConcept C2777752497 @default.
• W3120674329 hasConcept C2779428903 @default.
• W3120674329 hasConcept C2781357234 @default.
• W3120674329 hasConcept C55493867 @default.
• W3120674329 hasConcept C71315377 @default.
• W3120674329 hasConcept C71924100 @default.
• W3120674329 hasConcept C8264082 @default.
• W3120674329 hasConcept C86803240 @default.
• W3120674329 hasConcept C88045685 @default.
• W3120674329 hasConcept C98274493 @default.
• W3120674329 hasConceptScore W3120674329C104317684 @default.
• W3120674329 hasConceptScore W3120674329C109316439 @default.
• W3120674329 hasConceptScore W3120674329C126322002 @default.
• W3120674329 hasConceptScore W3120674329C127561419 @default.
• W3120674329 hasConceptScore W3120674329C150903083 @default.

• next