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• W3120675101 endingPage "173866" @default.
• W3120675101 startingPage "173866" @default.
• W3120675101 abstract "Metastatic breast cancer is a significant contributor to mortality among women, but its complex regulation represents a barrier to precision targeting. In the present study, a graphene-based nanocomposite which probes and selectively inhibits cancer cell motility is described. By controllable coupling of prenylated chalcone xanthohumol, an efficient inhibitor of mitochondrial electron transport chain complex I, with PEGylated graphene oxide nanosheet, a [email protected] nanocomposite with good stability and biocompatibility is synthesized. [email protected] is capable of inhibiting mitochondrial oxidative phosphorylation selectively in MDA-MB-231 and MDA-MB-436 metastatic breast cancer cells. [email protected] reduces the production of ATP, impairs the formation of F-actin cytoskeleton in the lamellipodia, and blocks the migration and invasion of breast cancer cells in vitro, without interfering the proliferation and metabolism of non-cancerous cells. More importantly, [email protected] suppresses the metastasis of MDA-MB-231 cells to lung in nude mice. [email protected] abolishes the TGF-β1-induced down-regulation of E-cadherin and up-regulation of N-cadherin, vimentin, Snail and Twist, thus causes the maintenance of “epithelial-like” rather than the “mesenchymal-like” features, and decreases the motility potential of breast cancer cells. Taken together, this research unveils the enormous potential of [email protected] to suppress metastatic breast cancer by selective targeting oxidative phosphorylation and epithelial-mesenchymal transition of cancer cells and thereby providing insights on metastatic cancer treatment." @default.
• W3120675101 created "2021-01-18" @default.
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• W3120675101 date "2021-03-01" @default.
• W3120675101 modified "2023-09-29" @default.
• W3120675101 title "PEG-GO@XN nanocomposite suppresses breast cancer metastasis via inhibition of mitochondrial oxidative phosphorylation and blockade of epithelial-to-mesenchymal transition" @default.
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• W3120675101 doi "https://doi.org/10.1016/j.ejphar.2021.173866" @default.
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• W3120675101 hasPublicationYear "2021" @default.
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