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- W3120677772 endingPage "113156" @default.
- W3120677772 startingPage "113156" @default.
- W3120677772 abstract "Glycorandomization is a natural product derivatization strategy in which different sugar moieties are linked to the aglycone part of the naturally existing glycosides to create glycorandomized libraries. Sugars attached to the natural products are responsible for affecting their solubility, mechanism of action, target recognition, and toxicity and thus, by changing the sugar part, these properties could be modified. Glycorandomization can be done via two approaches (i) a synthetic approach known as neoglycorandomization, and (ii) chemoenzymatic approach including in-vitro and in-vivo glycorandomization. Glycorandomization can be a promising technology for the drug discovery that has proved its potential to improve pharmacokinetic (solubility) and pharmacodynamic profile (mechanism of action, toxicity, and target recognition) of the parent compounds. The substrate flexibility of glycosyltransferases and other enzymes towards sugars and/or aglycone substrates has made this technique versatile. Further, the enzymes can be altered by genetic engineering to generate glycorandomized libraries of diverse natural product scaffolds. This technique has the potential to produce new compounds that can be helpful to the mankind by treating the threatening disease states. This review covers the different strategies for glycorandomization as a tool in drug discovery and development. The fundamentals of glycorandomization, different types, and further development of differentially glycorandomized libraries of natural products and small molecule based drugs have been discussed." @default.
- W3120677772 created "2021-01-18" @default.
- W3120677772 creator A5016480596 @default.
- W3120677772 creator A5044789984 @default.
- W3120677772 creator A5058789499 @default.
- W3120677772 creator A5060685591 @default.
- W3120677772 date "2021-03-01" @default.
- W3120677772 modified "2023-10-01" @default.
- W3120677772 title "Glycorandomization: A promising diversification strategy for the drug development" @default.
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