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• W3120702037 abstract "Abstract Objective The Low Middle Income Countries (LMIC) like Pakistan are facing an escalation in the number of HIV cases, approximately more than 180,000 people are currently living with HIV/AIDS (PLWHA). Currently, no HIV specific Health Related Quality of Life (HRQoL) tool is validated in Pakistan; therefore, the current analysis was aimed at translating and examining the psychometric properties of the Urdu version of WHOQOL HIV BREF among HIV patients of Pakistan. Methods The standard forward-backwards translation technique was used for Urdu translation of the instrument. Based on the principle of 5 subjects minimally for each item, a sample of 182 patients were recruited by employing a universal random sampling technique. Data were analysed to measure reliability, internal consistency, known-group, multivariable linear regression and construct validity. Results High internal consistency 0.93 (Cronbach alpha) was found for all WHOQOL HIV Bref facets. The test-retest reliability analysis demonstrated a statistically significant Interclass Correlation Coefficient (ICC) ranged from 0.88 – 0.98 (p < 0.001). In known group validity, lower CD-4 lymphocytes count was significantly related to poor scores for all six domains (p < 0.001). Similarly, symptomatic subjects had significantly lower scores compared to asymptomatic subjects on the physical, psychological, social relationship and independence domains (p < 0.05). Results also revealed a statistically significant positive correlation of all six domains with CD4 count (p < 0.001), exhibiting patients with higher CD-4 lymphocytes count will have higher mean scores of all six domains. Factor analysis revealed 5 domains, including Physical health, Psychological health, Social relationship, Environmental, and Spiritual health. When all domains were assessed together via Multivariable linear regression analysis; only physical, psychological health and environment health domains were found significantly associated with higher CD-4 lymphocytes count (Beta = 0.121, p < 0.001, Beta = 0.103, p = 0.002, and Beta = 0.032, p = 0.032). Conclusion Findings suggested that the Urdu version of WHOQOL HIV Bref is a psychometrically valid tool for measuring HRQoL." @default.
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• W3120702037 date "2020-06-15" @default.
• W3120702037 modified "2023-09-26" @default.
• W3120702037 title "Psychometric assessment of translated Urdu version of WHOQOL-HIV BREF among patients living with HIV" @default.
• W3120702037 doi "https://doi.org/10.21203/rs.3.rs-34790/v1" @default.
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