FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120704017> ?p ?o ?g. }

• W3120704017 abstract "Abstract Background: Generally, the incidence rate of colorectal cancer (CRC) is increasing among young patients (aged <49 years), while the reasons for the rising incidence are unclear. Indicative variables, such as tumour location, gender preference and genetic preponderance have not been followed up in a consistent manner. The current study was primarily conducted to improve the hereditary CRC screening programme by assessing the demographic and pathological characteristics of early-onset CRC compared to late-onset CRC in northeast Iran. Methods: This retrospective study was carried out over a three-year follow-up period (2014-2017) and included 562 CRC patients in three Mashhad City hospital laboratories in north-eastern Iran. We applied comparative analysis of pathological and familial features together with information on the presence of genetic mismatch repair-deficiency in relation to final patient status (surviving versus deceased cases). Analyses using R studio software were performed on early-onset CRC (n=222) and late-onset CRC (n=340) groups produced by division at the age of 50 years. Results: From an age-of-onset point of view, the distribution between the genders differed with females showing a higher proportion of early-onset CRC compared to men (56% vs. 44 %) , while the late-onset CRC disparity was less pronounced (48% vs. 52%). The mean age of all participants was 55.6 ± 14.8 years, while it was 40.3 ± 7.3 years for early-onset CRC and 65.1 ± 9.3 years for late-onset CRC. With respect to anatomical tumour location (distal, rectal, and proximal), the frequencies were 61%, 28% and 11%, respectively, but the variation did not reach statically significance. There was a dramatic difference with regard to the history of CRC in second-degree relatives (SDR) and that of the combination of first-degree relatives and SDR ( p =0.001 and p =0.03, respectively). Expression of the MLH1 and PMS2 genes were significantly different between survivors and deceased, however this finding was not observed with regard to the MSH6 and the MSH2 genes. Conclusion: The variation of demographic, pathological and genetic characteristics of CRC between early-onset and late-onset cancers of this kind emphasizes the need for a well-defined algorithm to identify high-risk patients." @default.
• W3120704017 created "2021-01-18" @default.
• W3120704017 creator A5012414416 @default.
• W3120704017 creator A5024573450 @default.
• W3120704017 creator A5050410655 @default.
• W3120704017 creator A5051437242 @default.
• W3120704017 creator A5051506988 @default.
• W3120704017 creator A5060897197 @default.
• W3120704017 creator A5077765139 @default.
• W3120704017 creator A5081460837 @default.
• W3120704017 creator A5081689734 @default.
• W3120704017 date "2021-01-06" @default.
• W3120704017 modified "2023-10-16" @default.
• W3120704017 title "Colorectal Cancer in Iran: A Retrospective, Comparative Study of Early-onset and Late-onset Cases in north-eastern Iran based on the Iranian Hereditary Colorectal Cancer Registry" @default.
• W3120704017 doi "https://doi.org/10.21203/rs.3.rs-137344/v1" @default.
• W3120704017 hasPublicationYear "2021" @default.
• W3120704017 type Work @default.
• W3120704017 sameAs 3120704017 @default.
• W3120704017 citedByCount "0" @default.
• W3120704017 crossrefType "posted-content" @default.
• W3120704017 hasAuthorship W3120704017A5012414416 @default.
• W3120704017 hasAuthorship W3120704017A5024573450 @default.
• W3120704017 hasAuthorship W3120704017A5050410655 @default.
• W3120704017 hasAuthorship W3120704017A5051437242 @default.
• W3120704017 hasAuthorship W3120704017A5051506988 @default.
• W3120704017 hasAuthorship W3120704017A5060897197 @default.
• W3120704017 hasAuthorship W3120704017A5077765139 @default.
• W3120704017 hasAuthorship W3120704017A5081460837 @default.
• W3120704017 hasAuthorship W3120704017A5081689734 @default.
• W3120704017 hasBestOaLocation W31207040171 @default.
• W3120704017 hasConcept C120665830 @default.
• W3120704017 hasConcept C121332964 @default.
• W3120704017 hasConcept C121608353 @default.
• W3120704017 hasConcept C126322002 @default.
• W3120704017 hasConcept C144024400 @default.
• W3120704017 hasConcept C149923435 @default.
• W3120704017 hasConcept C167135981 @default.
• W3120704017 hasConcept C187212893 @default.
• W3120704017 hasConcept C207886595 @default.
• W3120704017 hasConcept C2777767895 @default.
• W3120704017 hasConcept C2778527826 @default.
• W3120704017 hasConcept C2779134260 @default.
• W3120704017 hasConcept C526805850 @default.
• W3120704017 hasConcept C61511704 @default.
• W3120704017 hasConcept C71924100 @default.
• W3120704017 hasConceptScore W3120704017C120665830 @default.
• W3120704017 hasConceptScore W3120704017C121332964 @default.
• W3120704017 hasConceptScore W3120704017C121608353 @default.
• W3120704017 hasConceptScore W3120704017C126322002 @default.
• W3120704017 hasConceptScore W3120704017C144024400 @default.
• W3120704017 hasConceptScore W3120704017C149923435 @default.
• W3120704017 hasConceptScore W3120704017C167135981 @default.
• W3120704017 hasConceptScore W3120704017C187212893 @default.
• W3120704017 hasConceptScore W3120704017C207886595 @default.
• W3120704017 hasConceptScore W3120704017C2777767895 @default.
• W3120704017 hasConceptScore W3120704017C2778527826 @default.
• W3120704017 hasConceptScore W3120704017C2779134260 @default.
• W3120704017 hasConceptScore W3120704017C526805850 @default.
• W3120704017 hasConceptScore W3120704017C61511704 @default.
• W3120704017 hasConceptScore W3120704017C71924100 @default.
• W3120704017 hasLocation W31207040171 @default.
• W3120704017 hasOpenAccess W3120704017 @default.
• W3120704017 hasPrimaryLocation W31207040171 @default.
• W3120704017 hasRelatedWork W1992973544 @default.
• W3120704017 hasRelatedWork W2108089761 @default.
• W3120704017 hasRelatedWork W2324781352 @default.
• W3120704017 hasRelatedWork W2328806228 @default.
• W3120704017 hasRelatedWork W2404263546 @default.
• W3120704017 hasRelatedWork W2409957712 @default.
• W3120704017 hasRelatedWork W2522427908 @default.
• W3120704017 hasRelatedWork W2756083593 @default.
• W3120704017 hasRelatedWork W2793187211 @default.
• W3120704017 hasRelatedWork W3043892729 @default.
• W3120704017 isParatext "false" @default.
• W3120704017 isRetracted "false" @default.
• W3120704017 magId "3120704017" @default.
• W3120704017 workType "article" @default.