Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120706779> ?p ?o ?g. }
- W3120706779 endingPage "141" @default.
- W3120706779 startingPage "141" @default.
- W3120706779 abstract "Hypoxia is the most common microenvironment feature of lung cancer tumors, which affects cancer progression, metastasis and metabolism. Oxygen induces both proteomic and genomic changes within tumor cells, which cause many alternations in the tumor microenvironment (TME). This review defines current knowledge in the field of tumor hypoxia in non-small cell lung cancer (NSCLC), including biology, biomarkers, in vitro and in vivo studies and also hypoxia imaging and detection. While classic two-dimensional (2D) in vitro research models reveal some hypoxia dependent manifestations, three-dimensional (3D) cell culture models more accurately replicate the hypoxic TME. In this study, a systematic review of the current NSCLC 3D models that have been able to mimic the hypoxic TME is presented. The multicellular tumor spheroid, organoids, scaffolds, microfluidic devices and 3D bioprinting currently being utilized in NSCLC hypoxia studies are reviewed. Additionally, the utilization of 3D in vitro models for exploring biological and therapeutic parameters in the future is described." @default.
- W3120706779 created "2021-01-18" @default.
- W3120706779 creator A5006932981 @default.
- W3120706779 date "2021-01-12" @default.
- W3120706779 modified "2023-09-26" @default.
- W3120706779 title "Mimicking Tumor Hypoxia in Non-Small Cell Lung Cancer Employing Three-Dimensional In Vitro Models" @default.
- W3120706779 cites W1255078848 @default.
- W3120706779 cites W1855836187 @default.
- W3120706779 cites W1964008282 @default.
- W3120706779 cites W1965827991 @default.
- W3120706779 cites W1971886895 @default.
- W3120706779 cites W1972048759 @default.
- W3120706779 cites W1979264220 @default.
- W3120706779 cites W1981207410 @default.
- W3120706779 cites W1982845574 @default.
- W3120706779 cites W2009520390 @default.
- W3120706779 cites W2011810742 @default.
- W3120706779 cites W2018722597 @default.
- W3120706779 cites W2020021056 @default.
- W3120706779 cites W2020277250 @default.
- W3120706779 cites W2022060260 @default.
- W3120706779 cites W2024139498 @default.
- W3120706779 cites W2024206845 @default.
- W3120706779 cites W2028001877 @default.
- W3120706779 cites W2028916882 @default.
- W3120706779 cites W2029452593 @default.
- W3120706779 cites W2035954579 @default.
- W3120706779 cites W2045051280 @default.
- W3120706779 cites W2048466758 @default.
- W3120706779 cites W2056294995 @default.
- W3120706779 cites W2061277132 @default.
- W3120706779 cites W2065642253 @default.
- W3120706779 cites W2069224399 @default.
- W3120706779 cites W2073292880 @default.
- W3120706779 cites W2079096821 @default.
- W3120706779 cites W2079121632 @default.
- W3120706779 cites W2081947987 @default.
- W3120706779 cites W2085609942 @default.
- W3120706779 cites W2085650758 @default.
- W3120706779 cites W2090950165 @default.
- W3120706779 cites W2094447832 @default.
- W3120706779 cites W2096719505 @default.
- W3120706779 cites W2117418875 @default.
- W3120706779 cites W2118019849 @default.
- W3120706779 cites W2118727162 @default.
- W3120706779 cites W2119490571 @default.
- W3120706779 cites W2123894943 @default.
- W3120706779 cites W2127852790 @default.
- W3120706779 cites W2128112439 @default.
- W3120706779 cites W2130840255 @default.
- W3120706779 cites W2132719707 @default.
- W3120706779 cites W2133164395 @default.
- W3120706779 cites W2149860897 @default.
- W3120706779 cites W2150499465 @default.
- W3120706779 cites W2153438036 @default.
- W3120706779 cites W2156443974 @default.
- W3120706779 cites W2162158893 @default.
- W3120706779 cites W2163700401 @default.
- W3120706779 cites W2167510293 @default.
- W3120706779 cites W2289291437 @default.
- W3120706779 cites W2332155194 @default.
- W3120706779 cites W2396512494 @default.
- W3120706779 cites W2416829685 @default.
- W3120706779 cites W2472596403 @default.
- W3120706779 cites W2512537564 @default.
- W3120706779 cites W2513249090 @default.
- W3120706779 cites W2518853827 @default.
- W3120706779 cites W2520967373 @default.
- W3120706779 cites W2560447818 @default.
- W3120706779 cites W2602256043 @default.
- W3120706779 cites W2613629789 @default.
- W3120706779 cites W2614063400 @default.
- W3120706779 cites W2620579988 @default.
- W3120706779 cites W2727172327 @default.
- W3120706779 cites W2747471282 @default.
- W3120706779 cites W2749613778 @default.
- W3120706779 cites W2752427962 @default.
- W3120706779 cites W2760900181 @default.
- W3120706779 cites W2770519390 @default.
- W3120706779 cites W2790797622 @default.
- W3120706779 cites W2791551019 @default.
- W3120706779 cites W2799736418 @default.
- W3120706779 cites W2806595862 @default.
- W3120706779 cites W2884367460 @default.
- W3120706779 cites W2889646458 @default.
- W3120706779 cites W2900569176 @default.
- W3120706779 cites W2902223136 @default.
- W3120706779 cites W2906267672 @default.
- W3120706779 cites W2909367962 @default.
- W3120706779 cites W2911271053 @default.
- W3120706779 cites W2914525558 @default.
- W3120706779 cites W2916157147 @default.
- W3120706779 cites W2921770849 @default.
- W3120706779 cites W2939036329 @default.
- W3120706779 cites W2947165337 @default.
- W3120706779 cites W2967121126 @default.
- W3120706779 cites W2971872568 @default.
- W3120706779 cites W2979223301 @default.