FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120717287> ?p ?o ?g. }

• W3120717287 endingPage "142" @default.
• W3120717287 startingPage "128" @default.
• W3120717287 abstract "Acquired resistance is a challenge for epidermal growth factor receptor (EGFR) mutant non-small cell lung cancer. Here, we propose a novel treatment strategy based on recent lipid metabolism work.We applied a variety of experimental methods such as immunoblotting, MTT, si-RNA, and animal models, to demonstrate the relationship between EGFR and low-density lipoprotein receptor (LDLR) and the effects of statin monotherapy, and TKI monotherapy, and their combination on cell proliferation at the cell level and animal level.LDLR has a positive correlation with EGFR, EGFR signaling upregulates LDLR expression through the SREBP-1 dependent pathway, EGFR mutation cells count on lipids to survive and grow. Combined with a molecule-targeted drug, atorvastatin not only enhances the treatment effect in vitro, but also mitigates the growth of NSCLC in vivo. In this animal experiment, the combination medicine (atorvastatin with TKI) has a better tumor suppression effect on NSCLC. In HCC827 cell line, the average tumor shrinkage is about 68% in Gefitinib group, and about 49% in atorvastatin group, but about 89% in combination group. In H1975 cell line, the average tumor shrinkage is about 18% in Osimertinib group, and about 8% in atorvastatin group, but about 44% in combination group.the combination of an EGFR-TKI and a statin for EGFR mutant NSCLC may be a novel tumor inhibiting treatment." @default.
• W3120717287 created "2021-01-18" @default.
• W3120717287 creator A5015957073 @default.
• W3120717287 creator A5022757746 @default.
• W3120717287 creator A5023899283 @default.
• W3120717287 creator A5034700973 @default.
• W3120717287 creator A5036740868 @default.
• W3120717287 creator A5040647242 @default.
• W3120717287 creator A5046131158 @default.
• W3120717287 creator A5048587048 @default.
• W3120717287 creator A5063114025 @default.
• W3120717287 creator A5066716873 @default.
• W3120717287 date "2021-01-01" @default.
• W3120717287 modified "2023-09-24" @default.
• W3120717287 title "Cholesterol synthesis disruption combined with a molecule-targeted drug is a promising metabolic therapy for EGFR mutant non-small cell lung cancer" @default.
• W3120717287 cites W1977773843 @default.
• W3120717287 cites W2010518541 @default.
• W3120717287 cites W2021312892 @default.
• W3120717287 cites W2028897202 @default.
• W3120717287 cites W2037132483 @default.
• W3120717287 cites W2046994096 @default.
• W3120717287 cites W2048162805 @default.
• W3120717287 cites W2063673863 @default.
• W3120717287 cites W2066364577 @default.
• W3120717287 cites W2088270805 @default.
• W3120717287 cites W2096198395 @default.
• W3120717287 cites W2104450983 @default.
• W3120717287 cites W2111662961 @default.
• W3120717287 cites W2143859186 @default.
• W3120717287 cites W2154969724 @default.
• W3120717287 cites W2166084034 @default.
• W3120717287 cites W2198435241 @default.
• W3120717287 cites W2318531023 @default.
• W3120717287 cites W2494292000 @default.
• W3120717287 cites W2588061679 @default.
• W3120717287 cites W2620247054 @default.
• W3120717287 cites W2741524908 @default.
• W3120717287 cites W2770828094 @default.
• W3120717287 cites W2795708883 @default.
• W3120717287 cites W2889641359 @default.
• W3120717287 cites W2889646458 @default.
• W3120717287 cites W2889916070 @default.
• W3120717287 cites W2903043657 @default.
• W3120717287 cites W2905294241 @default.
• W3120717287 cites W2908891533 @default.
• W3120717287 cites W4241187049 @default.
• W3120717287 doi "https://doi.org/10.21037/tlcr-20-812" @default.
• W3120717287 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7867776" @default.
• W3120717287 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33569299" @default.
• W3120717287 hasPublicationYear "2021" @default.
• W3120717287 type Work @default.
• W3120717287 sameAs 3120717287 @default.
• W3120717287 citedByCount "11" @default.
• W3120717287 countsByYear W31207172872021 @default.
• W3120717287 countsByYear W31207172872022 @default.
• W3120717287 countsByYear W31207172872023 @default.
• W3120717287 crossrefType "journal-article" @default.
• W3120717287 hasAuthorship W3120717287A5015957073 @default.
• W3120717287 hasAuthorship W3120717287A5022757746 @default.
• W3120717287 hasAuthorship W3120717287A5023899283 @default.
• W3120717287 hasAuthorship W3120717287A5034700973 @default.
• W3120717287 hasAuthorship W3120717287A5036740868 @default.
• W3120717287 hasAuthorship W3120717287A5040647242 @default.
• W3120717287 hasAuthorship W3120717287A5046131158 @default.
• W3120717287 hasAuthorship W3120717287A5048587048 @default.
• W3120717287 hasAuthorship W3120717287A5063114025 @default.
• W3120717287 hasAuthorship W3120717287A5066716873 @default.
• W3120717287 hasBestOaLocation W31207172871 @default.
• W3120717287 hasConcept C121608353 @default.
• W3120717287 hasConcept C126322002 @default.
• W3120717287 hasConcept C150903083 @default.
• W3120717287 hasConcept C207001950 @default.
• W3120717287 hasConcept C2776256026 @default.
• W3120717287 hasConcept C2776839432 @default.
• W3120717287 hasConcept C2776999253 @default.
• W3120717287 hasConcept C2777482532 @default.
• W3120717287 hasConcept C2777506169 @default.
• W3120717287 hasConcept C2777626846 @default.
• W3120717287 hasConcept C2778087573 @default.
• W3120717287 hasConcept C2778163477 @default.
• W3120717287 hasConcept C2779438470 @default.
• W3120717287 hasConcept C2780072125 @default.
• W3120717287 hasConcept C2780580887 @default.
• W3120717287 hasConcept C2781230642 @default.
• W3120717287 hasConcept C2909325608 @default.
• W3120717287 hasConcept C43554185 @default.
• W3120717287 hasConcept C502942594 @default.
• W3120717287 hasConcept C55493867 @default.
• W3120717287 hasConcept C62112901 @default.
• W3120717287 hasConcept C71924100 @default.
• W3120717287 hasConcept C86803240 @default.
• W3120717287 hasConcept C98274493 @default.
• W3120717287 hasConceptScore W3120717287C121608353 @default.
• W3120717287 hasConceptScore W3120717287C126322002 @default.
• W3120717287 hasConceptScore W3120717287C150903083 @default.
• W3120717287 hasConceptScore W3120717287C207001950 @default.
• W3120717287 hasConceptScore W3120717287C2776256026 @default.
• W3120717287 hasConceptScore W3120717287C2776839432 @default.

• next