Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120725519> ?p ?o ?g. }
- W3120725519 endingPage "88" @default.
- W3120725519 startingPage "80" @default.
- W3120725519 abstract "Radiation damage of healthy tissues represents one of the complications of radiotherapy effectiveness. This study is focused on the screening of potentially effective drugs routinely used in medical practice and involved in the mechanism of radiation injury, namely for radiation-induced production of free radicals in the body. Experiments in rats revealed significant reduction of oxidative stress (malondialdehyde) and inflammatory marker (tumor necrosis factor α) in 10 Gy irradiated groups after administration of atorvastatin and a slight decrease after tadalafil administration, which indicates that one of the possible mechanisms for mitigation of radiation-induced cardiac damage could be the modulation of nitric oxide (NO) in endothelium and phosphodiesterase 5. In addition, miRNAs were analyzed as potential markers and therapeutically effective molecules. Expression of miRNA-21 and miRNA-15b showed the most significant changes after irradiation. Atorvastatin and tadalafil normalized changes of miRNA (miRNA-1, miRNA-15b, miRNA-21) expression levels in irradiated hearts. This screening study concludes that administration of specific drugs could mitigate the negative impact of radiation on the heart, but more detailed experiments oriented to other aspects of drug effectiveness and their exact mechanisms are still needed." @default.
- W3120725519 created "2021-01-18" @default.
- W3120725519 creator A5003962544 @default.
- W3120725519 creator A5012440472 @default.
- W3120725519 creator A5014898755 @default.
- W3120725519 creator A5020618098 @default.
- W3120725519 creator A5028676607 @default.
- W3120725519 creator A5037626786 @default.
- W3120725519 creator A5047595986 @default.
- W3120725519 creator A5049356678 @default.
- W3120725519 creator A5085436237 @default.
- W3120725519 date "2021-01-01" @default.
- W3120725519 modified "2023-09-27" @default.
- W3120725519 title "The effect of selected drugs on the mitigation of myocardial injury caused by gamma radiation" @default.
- W3120725519 cites W1732667972 @default.
- W3120725519 cites W1912692550 @default.
- W3120725519 cites W1922357645 @default.
- W3120725519 cites W1971416757 @default.
- W3120725519 cites W1973349963 @default.
- W3120725519 cites W1976277922 @default.
- W3120725519 cites W1978545009 @default.
- W3120725519 cites W1979094235 @default.
- W3120725519 cites W1983679827 @default.
- W3120725519 cites W1989877335 @default.
- W3120725519 cites W1996209758 @default.
- W3120725519 cites W1997538832 @default.
- W3120725519 cites W1998914290 @default.
- W3120725519 cites W1999943920 @default.
- W3120725519 cites W2011552323 @default.
- W3120725519 cites W2012435004 @default.
- W3120725519 cites W2014237668 @default.
- W3120725519 cites W2020983524 @default.
- W3120725519 cites W2028216259 @default.
- W3120725519 cites W2030592087 @default.
- W3120725519 cites W2044007563 @default.
- W3120725519 cites W2044351980 @default.
- W3120725519 cites W2055239715 @default.
- W3120725519 cites W2057955197 @default.
- W3120725519 cites W2062678616 @default.
- W3120725519 cites W2077878390 @default.
- W3120725519 cites W2085237061 @default.
- W3120725519 cites W2097105426 @default.
- W3120725519 cites W2100684141 @default.
- W3120725519 cites W2101144156 @default.
- W3120725519 cites W2104610341 @default.
- W3120725519 cites W2107387191 @default.
- W3120725519 cites W2112728084 @default.
- W3120725519 cites W2127708948 @default.
- W3120725519 cites W2128635872 @default.
- W3120725519 cites W2132093971 @default.
- W3120725519 cites W2135083563 @default.
- W3120725519 cites W2141377488 @default.
- W3120725519 cites W2144292349 @default.
- W3120725519 cites W2146306600 @default.
- W3120725519 cites W2154375587 @default.
- W3120725519 cites W2155187432 @default.
- W3120725519 cites W2155302688 @default.
- W3120725519 cites W2166270712 @default.
- W3120725519 cites W2166502047 @default.
- W3120725519 cites W2182233876 @default.
- W3120725519 cites W2339652829 @default.
- W3120725519 cites W2414173680 @default.
- W3120725519 cites W2521178361 @default.
- W3120725519 cites W2566574265 @default.
- W3120725519 cites W2592241264 @default.
- W3120725519 cites W2727516623 @default.
- W3120725519 cites W2740086969 @default.
- W3120725519 cites W2782074409 @default.
- W3120725519 cites W2798268390 @default.
- W3120725519 cites W2809559728 @default.
- W3120725519 cites W2814616126 @default.
- W3120725519 cites W2883344612 @default.
- W3120725519 cites W2890838471 @default.
- W3120725519 cites W2914441868 @default.
- W3120725519 cites W2919993302 @default.
- W3120725519 cites W2937300608 @default.
- W3120725519 cites W2939903011 @default.
- W3120725519 cites W2963992945 @default.
- W3120725519 cites W2967681759 @default.
- W3120725519 cites W2967697545 @default.
- W3120725519 cites W2991654492 @default.
- W3120725519 cites W2996769041 @default.
- W3120725519 cites W3001817526 @default.
- W3120725519 cites W3002752101 @default.
- W3120725519 cites W3003157851 @default.
- W3120725519 cites W4211047418 @default.
- W3120725519 cites W4238576738 @default.
- W3120725519 cites W4248269777 @default.
- W3120725519 doi "https://doi.org/10.1139/cjpp-2020-0323" @default.
- W3120725519 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33438486" @default.
- W3120725519 hasPublicationYear "2021" @default.
- W3120725519 type Work @default.
- W3120725519 sameAs 3120725519 @default.
- W3120725519 citedByCount "2" @default.
- W3120725519 countsByYear W31207255192022 @default.
- W3120725519 crossrefType "journal-article" @default.
- W3120725519 hasAuthorship W3120725519A5003962544 @default.
- W3120725519 hasAuthorship W3120725519A5012440472 @default.