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- W3120750707 abstract "The molecular pathology of multi-organ injuries in COVID-19 patients remains unclear, preventing effective therapeutics development. Here, we report a proteomic analysis of 144 autopsy samples from seven organs in 19 COVID-19 patients. We quantified 11,394 proteins in these samples, in which 5,336 were perturbed in the COVID-19 patients compared to controls. Our data showed that cathepsin L1, rather than ACE2, was significantly upregulated in the lung from the COVID-19 patients. Systemic hyperinflammation and dysregulation of glucose and fatty acid metabolism were detected in multiple organs. We also observed dysregulation of key factors involved in hypoxia, angiogenesis, blood coagulation, and fibrosis in multiple organs from the COVID-19 patients. Evidence for testicular injuries includes reduced Leydig cells, suppressed cholesterol biosynthesis, and sperm mobility. In summary, this study depicts a multi-organ proteomic landscape of COVID-19 autopsies that furthers our understanding of the biological basis of COVID-19 pathology." @default.
- W3120750707 created "2021-01-18" @default.
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- W3120750707 date "2021-02-01" @default.
- W3120750707 modified "2023-10-17" @default.
- W3120750707 title "Multi-organ proteomic landscape of COVID-19 autopsies" @default.
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- W3120750707 cites W1983015423 @default.
- W3120750707 cites W1993324234 @default.
- W3120750707 cites W1999050752 @default.
- W3120750707 cites W2000209824 @default.
- W3120750707 cites W2004329603 @default.
- W3120750707 cites W2007199806 @default.
- W3120750707 cites W2012034410 @default.
- W3120750707 cites W2021540990 @default.
- W3120750707 cites W2027092108 @default.
- W3120750707 cites W2027260180 @default.
- W3120750707 cites W2032429373 @default.
- W3120750707 cites W2033883291 @default.
- W3120750707 cites W2034269591 @default.
- W3120750707 cites W2043829974 @default.
- W3120750707 cites W2044227662 @default.
- W3120750707 cites W2050577046 @default.
- W3120750707 cites W2050622384 @default.
- W3120750707 cites W2055209830 @default.
- W3120750707 cites W2058780476 @default.
- W3120750707 cites W2079533675 @default.
- W3120750707 cites W2081415617 @default.
- W3120750707 cites W2090548697 @default.
- W3120750707 cites W2090885909 @default.
- W3120750707 cites W2097708776 @default.
- W3120750707 cites W2101803219 @default.
- W3120750707 cites W2109639180 @default.
- W3120750707 cites W2112119237 @default.
- W3120750707 cites W2120494989 @default.
- W3120750707 cites W2123611122 @default.
- W3120750707 cites W2127653619 @default.
- W3120750707 cites W2129274801 @default.
- W3120750707 cites W2133416744 @default.
- W3120750707 cites W2135051642 @default.
- W3120750707 cites W2135919238 @default.
- W3120750707 cites W2145933752 @default.
- W3120750707 cites W2152723000 @default.
- W3120750707 cites W2158922816 @default.
- W3120750707 cites W2159675211 @default.