FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120768156> ?p ?o ?g. }

• W3120768156 endingPage "S788" @default.
• W3120768156 startingPage "S787" @default.
• W3120768156 abstract "Abstract Background Trimethoprim-sulfamethoxazole (T/S) and levofloxacin are considered first line agents for the treatment of Burkholderia cepacia complex (Bcc). Combination therapy (CT) is frequently utilized despite limited clinical evidence supporting this. The objective of this study is to compare outcomes associated with different regimens for the treatment of Bcc infections. Methods This is a retrospective cohort study in non-cystic fibrosis adult patients with infection caused by Bcc from 2015 to 2019. The primary outcome is the composite of overall treatment failure defined as clinical failure, microbiologic failure, or mortality at 30 days. Secondary outcomes include mortality, clinical failure, microbiological failure, development of resistance, recurrence, and safety. Comparisons were performed using Chi-squared or Fischer’s exact test for categorical variables and Student’s t test or the Mann-Whitney U test for continuous variables, as appropriate. Multivariable logistic regression analysis was used to identify independent risk factors for overall treatment failure. Results Sixty-eight patients were included, 50 (74%) received monotherapy (MT) and 18 (26%) received CT. MT regimens included meropenem (n=19), ceftazidime (n=15), T/S (n=10), and other (n=6). Various combination regimens were utilized. MT recipients were significantly older, more likely to have renal disease, less likely to have an immunosuppression, and had a higher severity of illness. The most common site of infection was respiratory (78%). No difference was found for overall treatment failure between MT and CT (36.0% vs. 38.9%; p=0.947). No differences were found in the secondary outcomes (Table 1). Overall treatment failure did not differ by treatment regimens utilized. On multivariable analysis controlling for age, renal disease, CCI, immunosuppression, ICU admission, SOFA score, and receipt of MT, only SOFA score was associated with treatment failure [OR 1.43 (95% CI 1.15 to 1.77); p=0.001] and not MT [OR 1.22 (95% CI 0.25 to 5.97); p=0.808]. Table 1: Treatment Outcomes – MT versus CT Conclusion There were no differences in outcomes between MT and CT groups for the treatment of Bcc infection. Treatment outcomes appeared to be driven primarily by disease severity. Additional studies are needed to identify the optimal treatment regimens. Disclosures All Authors: No reported disclosures" @default.
• W3120768156 created "2021-01-18" @default.
• W3120768156 creator A5026850240 @default.
• W3120768156 creator A5037263256 @default.
• W3120768156 creator A5063382165 @default.
• W3120768156 date "2020-10-01" @default.
• W3120768156 modified "2023-09-27" @default.
• W3120768156 title "1579. Burkholderia Returns: Are Two Drugs Better or Back to Bactrim?" @default.
• W3120768156 doi "https://doi.org/10.1093/ofid/ofaa439.1759" @default.
• W3120768156 hasPublicationYear "2020" @default.
• W3120768156 type Work @default.
• W3120768156 sameAs 3120768156 @default.
• W3120768156 citedByCount "0" @default.
• W3120768156 crossrefType "journal-article" @default.
• W3120768156 hasAuthorship W3120768156A5026850240 @default.
• W3120768156 hasAuthorship W3120768156A5037263256 @default.
• W3120768156 hasAuthorship W3120768156A5063382165 @default.
• W3120768156 hasBestOaLocation W31207681561 @default.
• W3120768156 hasConcept C126322002 @default.
• W3120768156 hasConcept C141071460 @default.
• W3120768156 hasConcept C167135981 @default.
• W3120768156 hasConcept C71924100 @default.
• W3120768156 hasConceptScore W3120768156C126322002 @default.
• W3120768156 hasConceptScore W3120768156C141071460 @default.
• W3120768156 hasConceptScore W3120768156C167135981 @default.
• W3120768156 hasConceptScore W3120768156C71924100 @default.
• W3120768156 hasIssue "Supplement_1" @default.
• W3120768156 hasLocation W31207681561 @default.
• W3120768156 hasLocation W31207681562 @default.
• W3120768156 hasLocation W31207681563 @default.
• W3120768156 hasOpenAccess W3120768156 @default.
• W3120768156 hasPrimaryLocation W31207681561 @default.
• W3120768156 hasRelatedWork W2002120878 @default.
• W3120768156 hasRelatedWork W2003938723 @default.
• W3120768156 hasRelatedWork W2047967234 @default.
• W3120768156 hasRelatedWork W2118496982 @default.
• W3120768156 hasRelatedWork W2364998975 @default.
• W3120768156 hasRelatedWork W2369162477 @default.
• W3120768156 hasRelatedWork W2439875401 @default.
• W3120768156 hasRelatedWork W4238867864 @default.
• W3120768156 hasRelatedWork W2519357708 @default.
• W3120768156 hasRelatedWork W2525756941 @default.
• W3120768156 hasVolume "7" @default.
• W3120768156 isParatext "false" @default.
• W3120768156 isRetracted "false" @default.
• W3120768156 magId "3120768156" @default.
• W3120768156 workType "article" @default.