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• W3120791330 abstract "Cisplatin chemotherapy often causes permanent hearing loss, which leads to a multifaceted decrease in quality of life. Identification of early cisplatin-induced cochlear damage would greatly improve clinical diagnosis and provide potential drug targets to prevent cisplatin's ototoxicity. With improved functional and immunocytochemical assays, a recent seminal discovery revealed that synaptic loss between inner hair cells and spiral ganglion neurons is a major form of early cochlear damage induced by noise exposure or aging. This breakthrough discovery prompted the current study to determine early functional, cellular, and molecular changes for cisplatin-induced hearing loss, in part to determine if synapse injury is caused by cisplatin exposure. Cisplatin was delivered in one to three treatment cycles to both male and female mice. After the cisplatin treatment of three cycles, threshold shift was observed across frequencies tested like previous studies. After the treatment of two cycles, beside loss of outer hair cells and an increase in high-frequency hearing thresholds, a significant latency delay of auditory brainstem response wave 1 was observed, including at a frequency region where there were no changes in hearing thresholds. The wave 1 latency delay was detected as early cisplatin-induced ototoxicity after only one cycle of treatment, in which no significant threshold shift was found. In the same mice, mitochondrial loss in the base of the cochlea and declining mitochondrial morphometric health were observed. Thus, we have identified early spiral ganglion-associated functional and cellular changes after cisplatin treatment that precede significant threshold shift." @default.
• W3120791330 created "2021-01-18" @default.
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• W3120791330 date "2021-01-07" @default.
• W3120791330 modified "2023-10-17" @default.
• W3120791330 title "Early Physiological and Cellular Indicators of Cisplatin-Induced Ototoxicity" @default.
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• W3120791330 cites W1967269886 @default.
• W3120791330 cites W1978080323 @default.
• W3120791330 cites W1979602376 @default.
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• W3120791330 cites W2007796957 @default.
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• W3120791330 cites W2020748502 @default.
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• W3120791330 doi "https://doi.org/10.1007/s10162-020-00782-z" @default.
• W3120791330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7943688" @default.
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• W3120791330 hasPublicationYear "2021" @default.
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