Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120791704> ?p ?o ?g. }
- W3120791704 endingPage "414" @default.
- W3120791704 startingPage "414" @default.
- W3120791704 abstract "Target-specific biomolecules, monoclonal antibodies (mAb), proteins, and protein fragments are known to have high specificity and affinity for receptors associated with tumors and other pathological conditions. However, the large biomolecules have relatively intermediate to long circulation half-lives (>day) and tumor localization times. Combining superior target specificity of mAbs and high sensitivity and resolution of the PET (Positron Emission Tomography) imaging technique has created a paradigm-shifting imaging modality, ImmunoPET. In addition to metallic PET radionuclides, 124I is an attractive radionuclide for radiolabeling of mAbs as potential immunoPET imaging pharmaceuticals due to its physical properties (decay characteristics and half-life), easy and routine production by cyclotrons, and well-established methodologies for radioiodination. The objective of this report is to provide a comprehensive review of the physical properties of iodine and iodine radionuclides, production processes of 124I, various 124I-labeling methodologies for large biomolecules, mAbs, and the development of 124I-labeled immunoPET imaging pharmaceuticals for various cancer targets in preclinical and clinical environments. A summary of several production processes, including 123Te(d,n)124I, 124Te(d,2n)124I, 121Sb(α,n)124I, 123Sb(α,3n)124I, 123Sb(3He,2n)124I, natSb(α, xn)124I, natSb(3He,n)124I reactions, a detailed overview of the 124Te(p,n)124I reaction (including target selection, preparation, processing, and recovery of 124I), and a fully automated process that can be scaled up for GMP (Good Manufacturing Practices) production of large quantities of 124I is provided. Direct, using inorganic and organic oxidizing agents and enzyme catalysis, and indirect, using prosthetic groups, 124I-labeling techniques have been discussed. Significant research has been conducted, in more than the last two decades, in the development of 124I-labeled immunoPET imaging pharmaceuticals for target-specific cancer detection. Details of preclinical and clinical evaluations of the potential 124I-labeled immunoPET imaging pharmaceuticals are described here." @default.
- W3120791704 created "2021-01-18" @default.
- W3120791704 creator A5017018764 @default.
- W3120791704 creator A5019744826 @default.
- W3120791704 date "2021-01-14" @default.
- W3120791704 modified "2023-10-11" @default.
- W3120791704 title "Radiochemistry, Production Processes, Labeling Methods, and ImmunoPET Imaging Pharmaceuticals of Iodine-124" @default.
- W3120791704 cites W10647373 @default.
- W3120791704 cites W1544486867 @default.
- W3120791704 cites W1553230769 @default.
- W3120791704 cites W1563799601 @default.
- W3120791704 cites W1583854931 @default.
- W3120791704 cites W1595868723 @default.
- W3120791704 cites W1623964449 @default.
- W3120791704 cites W1788773500 @default.
- W3120791704 cites W1852277107 @default.
- W3120791704 cites W1893651774 @default.
- W3120791704 cites W1963595566 @default.
- W3120791704 cites W1963749232 @default.
- W3120791704 cites W1968575643 @default.
- W3120791704 cites W1970636847 @default.
- W3120791704 cites W1971037117 @default.
- W3120791704 cites W1976569516 @default.
- W3120791704 cites W1976571671 @default.
- W3120791704 cites W1976577365 @default.
- W3120791704 cites W1977163268 @default.
- W3120791704 cites W1977303041 @default.
- W3120791704 cites W1977663329 @default.
- W3120791704 cites W1978053254 @default.
- W3120791704 cites W1978465832 @default.
- W3120791704 cites W1982322665 @default.
- W3120791704 cites W1982544588 @default.
- W3120791704 cites W1984256952 @default.
- W3120791704 cites W1984445202 @default.
- W3120791704 cites W1987729908 @default.
- W3120791704 cites W1988667194 @default.
- W3120791704 cites W1989280935 @default.
- W3120791704 cites W1990944220 @default.
- W3120791704 cites W1991377352 @default.
- W3120791704 cites W1993393105 @default.
- W3120791704 cites W1993804787 @default.
- W3120791704 cites W1996400431 @default.
- W3120791704 cites W1998418771 @default.
- W3120791704 cites W1999924649 @default.
- W3120791704 cites W2000984274 @default.
- W3120791704 cites W2001870440 @default.
- W3120791704 cites W2003613730 @default.
- W3120791704 cites W2004383099 @default.
- W3120791704 cites W2005946075 @default.
- W3120791704 cites W2007505205 @default.
- W3120791704 cites W2010721273 @default.
- W3120791704 cites W2011879044 @default.
- W3120791704 cites W2011949453 @default.
- W3120791704 cites W2012744044 @default.
- W3120791704 cites W2013197178 @default.
- W3120791704 cites W2013735638 @default.
- W3120791704 cites W2014164339 @default.
- W3120791704 cites W2017307891 @default.
- W3120791704 cites W2020804208 @default.
- W3120791704 cites W2021396643 @default.
- W3120791704 cites W2021489172 @default.
- W3120791704 cites W2021607519 @default.
- W3120791704 cites W2021749518 @default.
- W3120791704 cites W2024211846 @default.
- W3120791704 cites W2024423807 @default.
- W3120791704 cites W2025342781 @default.
- W3120791704 cites W2027508453 @default.
- W3120791704 cites W2027698934 @default.
- W3120791704 cites W2029473284 @default.
- W3120791704 cites W2029606475 @default.
- W3120791704 cites W2032231394 @default.
- W3120791704 cites W2032665990 @default.
- W3120791704 cites W2033785962 @default.
- W3120791704 cites W2034730058 @default.
- W3120791704 cites W2035271331 @default.
- W3120791704 cites W2035838265 @default.
- W3120791704 cites W2037551215 @default.
- W3120791704 cites W2038135361 @default.
- W3120791704 cites W2041080449 @default.
- W3120791704 cites W2041084734 @default.
- W3120791704 cites W2041894826 @default.
- W3120791704 cites W2042515981 @default.
- W3120791704 cites W2042598973 @default.
- W3120791704 cites W2044229641 @default.
- W3120791704 cites W2045010380 @default.
- W3120791704 cites W2045958189 @default.
- W3120791704 cites W2047151303 @default.
- W3120791704 cites W2048887283 @default.
- W3120791704 cites W2049292021 @default.
- W3120791704 cites W2050345527 @default.
- W3120791704 cites W2051066572 @default.
- W3120791704 cites W2051549313 @default.
- W3120791704 cites W2052549477 @default.
- W3120791704 cites W2052635554 @default.
- W3120791704 cites W2052755039 @default.
- W3120791704 cites W2053088103 @default.
- W3120791704 cites W2053982731 @default.
- W3120791704 cites W2054268008 @default.