Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120792158> ?p ?o ?g. }
- W3120792158 abstract "Horses worldwide suffer from equine recurrent uveitis (ERU), an organ-specific, immune-mediated disease with painful, remitting-relapsing inflammatory attacks alternating with periods of quiescence, which ultimately leads to blindness. In course of disease, both eyes can eventually be affected and since blind horses pose a threat to themselves and their surroundings, these animals have to be killed. Therefore, this disease is highly relevant for veterinary medicine. Additionally, ERU shows strong clinical and pathological resemblance to autoimmune uveitis in man. The exact cause for the onset of ERU is unclear to date. T cells are believed to be the main effector cells in this disease, as they overcome the blood retinal barrier to invade the eye, an organ physiologically devoid of peripheral immune cells. These cells cause severe intraocular inflammation, especially in their primary target, the retina. With every inflammatory episode, retinal degeneration increases until eyesight is completely lost. In ERU, T cells show an activated phenotype, with enhanced deformability and migration ability, which is reflected in the composition of their proteome and downstream interaction pathways even in quiescent stage of disease. Besides the dysregulation of adaptive immune cells, emerging evidence suggests that cells of the innate immune system may also directly contribute to ERU pathogenesis. As investigations in both the target organ and the periphery have rapidly evolved in recent years, giving new insights on pathogenesis-associated processes on cellular and molecular level, this review summarizes latest developments in ERU research." @default.
- W3120792158 created "2021-01-18" @default.
- W3120792158 creator A5045991073 @default.
- W3120792158 creator A5061990652 @default.
- W3120792158 date "2021-01-08" @default.
- W3120792158 modified "2023-10-14" @default.
- W3120792158 title "Immunological Insights in Equine Recurrent Uveitis" @default.
- W3120792158 cites W1491678226 @default.
- W3120792158 cites W1494966170 @default.
- W3120792158 cites W1514719903 @default.
- W3120792158 cites W1535854950 @default.
- W3120792158 cites W1607236619 @default.
- W3120792158 cites W1880955151 @default.
- W3120792158 cites W1913779731 @default.
- W3120792158 cites W1940887303 @default.
- W3120792158 cites W1964474770 @default.
- W3120792158 cites W1970017530 @default.
- W3120792158 cites W1972467243 @default.
- W3120792158 cites W1972596388 @default.
- W3120792158 cites W1973606339 @default.
- W3120792158 cites W1977871074 @default.
- W3120792158 cites W1980973795 @default.
- W3120792158 cites W1985581091 @default.
- W3120792158 cites W1986173652 @default.
- W3120792158 cites W1990067971 @default.
- W3120792158 cites W1991371383 @default.
- W3120792158 cites W1993016015 @default.
- W3120792158 cites W1993607801 @default.
- W3120792158 cites W1997826997 @default.
- W3120792158 cites W2001830452 @default.
- W3120792158 cites W2004471938 @default.
- W3120792158 cites W2011435677 @default.
- W3120792158 cites W2012156591 @default.
- W3120792158 cites W2013212307 @default.
- W3120792158 cites W2028233461 @default.
- W3120792158 cites W2028729697 @default.
- W3120792158 cites W2030454808 @default.
- W3120792158 cites W2031265038 @default.
- W3120792158 cites W2037533948 @default.
- W3120792158 cites W2039390487 @default.
- W3120792158 cites W2040153772 @default.
- W3120792158 cites W2043261014 @default.
- W3120792158 cites W2053835098 @default.
- W3120792158 cites W2054984177 @default.
- W3120792158 cites W2055234427 @default.
- W3120792158 cites W2056545905 @default.
- W3120792158 cites W2056575454 @default.
- W3120792158 cites W2058722090 @default.
- W3120792158 cites W2060411936 @default.
- W3120792158 cites W2061217789 @default.
- W3120792158 cites W2063053901 @default.
- W3120792158 cites W2064577212 @default.
- W3120792158 cites W2068953660 @default.
- W3120792158 cites W2070560299 @default.
- W3120792158 cites W2072356550 @default.
- W3120792158 cites W2073851077 @default.
- W3120792158 cites W2075624081 @default.
- W3120792158 cites W2077486579 @default.
- W3120792158 cites W2079655276 @default.
- W3120792158 cites W2080816502 @default.
- W3120792158 cites W2082253546 @default.
- W3120792158 cites W2084965636 @default.
- W3120792158 cites W2088753260 @default.
- W3120792158 cites W2089275254 @default.
- W3120792158 cites W2094779430 @default.
- W3120792158 cites W2104040734 @default.
- W3120792158 cites W2104662204 @default.
- W3120792158 cites W2105818591 @default.
- W3120792158 cites W2107083972 @default.
- W3120792158 cites W2107521022 @default.
- W3120792158 cites W2109806505 @default.
- W3120792158 cites W2111274886 @default.
- W3120792158 cites W2112215733 @default.
- W3120792158 cites W2114164467 @default.
- W3120792158 cites W2115717665 @default.
- W3120792158 cites W2133265333 @default.
- W3120792158 cites W2134804960 @default.
- W3120792158 cites W2146262948 @default.
- W3120792158 cites W2148149911 @default.
- W3120792158 cites W2148232659 @default.
- W3120792158 cites W2149410171 @default.
- W3120792158 cites W2150816880 @default.
- W3120792158 cites W2155965588 @default.
- W3120792158 cites W2158183837 @default.
- W3120792158 cites W2171654140 @default.
- W3120792158 cites W2267022665 @default.
- W3120792158 cites W2308785103 @default.
- W3120792158 cites W2314665568 @default.
- W3120792158 cites W2328283275 @default.
- W3120792158 cites W2335940376 @default.
- W3120792158 cites W2337495045 @default.
- W3120792158 cites W2461151271 @default.
- W3120792158 cites W2512686554 @default.
- W3120792158 cites W2525978589 @default.
- W3120792158 cites W2567722884 @default.
- W3120792158 cites W2591052835 @default.
- W3120792158 cites W2625667911 @default.
- W3120792158 cites W2626516341 @default.
- W3120792158 cites W2747418114 @default.
- W3120792158 cites W2761221630 @default.