Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120869461> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W3120869461 abstract "One of the hereditary factors affecting the development of breast and ovarian cancer is the 5382insC mutation in BRCA1 gene. But, nearly 15 % of carriers of this mutation do not manifest cancer during their lifetime. At present, the features of the development of spontaneous and induced genomic instability in asymptomatic carriers of BRCA1 mutations are studied insufficiently. The aim of the work was to evaluate the effect of the 5382insC BRCA1 mutation on the radiosensitivity of lymphocytes of individuals without an established oncopathology. The cultivation of blood lymphocytes obtained from 9 women (3 individuals with the 5382insC BRCA1 mutation without established oncopathology, and 6 conditionally healthy volunteers) was carried out. Some of the cultures were irradiated with γ-quanta (IBL-237C emitter, power 2.34 Gy/min) at a dose of 1.0 Gy before cultivation. For evaluation of the relative level of DNA damage the method of Сomet assay was applied. It was found that spontaneous level of DNA damage in cultures of lymphocytes of carriers of the BRCA1 5382insC mutation was statistically significantly (p < 0.01) higher than in the control group. After exposure to ionizing radiation for lymphocyte cultures of individuals with BRCA1 5382insC mutation, a decrease (p < 0.01) in the level of cells with a high degree of DNA damage was observed while the apoptotic activity was found to be increased (p < 0.01). It has been suggested that an increase in the elimination of damaged cells due to apoptotic activity in response to the action of genome-damaging factors is one of the effective mechanisms that can significantly reduce the likelihood of cancer in asymptomatic carriers of the BRCA1 gene mutations." @default.
- W3120869461 created "2021-01-18" @default.
- W3120869461 creator A5014284178 @default.
- W3120869461 creator A5029185265 @default.
- W3120869461 creator A5030098859 @default.
- W3120869461 creator A5032886365 @default.
- W3120869461 creator A5058187277 @default.
- W3120869461 date "2020-01-01" @default.
- W3120869461 modified "2023-09-26" @default.
- W3120869461 title "The impact of ionizing irradiation in vitro on the genome of peripheral blood lymphocytes of the asymptomatic carriers of the 5382insC mutation in the BRCA1 gene" @default.
- W3120869461 cites W2007458878 @default.
- W3120869461 cites W2034594496 @default.
- W3120869461 cites W2059365987 @default.
- W3120869461 cites W2066969492 @default.
- W3120869461 cites W2323655901 @default.
- W3120869461 cites W2328105863 @default.
- W3120869461 cites W2337657037 @default.
- W3120869461 cites W2494429640 @default.
- W3120869461 cites W2789920765 @default.
- W3120869461 cites W2807649309 @default.
- W3120869461 cites W2895407030 @default.
- W3120869461 cites W2943415606 @default.
- W3120869461 cites W2954014685 @default.
- W3120869461 cites W3005417928 @default.
- W3120869461 cites W3007516256 @default.
- W3120869461 doi "https://doi.org/10.17721/1728_2748.2020.83.55-61" @default.
- W3120869461 hasPublicationYear "2020" @default.
- W3120869461 type Work @default.
- W3120869461 sameAs 3120869461 @default.
- W3120869461 citedByCount "0" @default.
- W3120869461 crossrefType "journal-article" @default.
- W3120869461 hasAuthorship W3120869461A5014284178 @default.
- W3120869461 hasAuthorship W3120869461A5029185265 @default.
- W3120869461 hasAuthorship W3120869461A5030098859 @default.
- W3120869461 hasAuthorship W3120869461A5032886365 @default.
- W3120869461 hasAuthorship W3120869461A5058187277 @default.
- W3120869461 hasBestOaLocation W31208694611 @default.
- W3120869461 hasConcept C104317684 @default.
- W3120869461 hasConcept C111337013 @default.
- W3120869461 hasConcept C121332964 @default.
- W3120869461 hasConcept C126322002 @default.
- W3120869461 hasConcept C13514818 @default.
- W3120869461 hasConcept C137916694 @default.
- W3120869461 hasConcept C143425029 @default.
- W3120869461 hasConcept C153911025 @default.
- W3120869461 hasConcept C178169997 @default.
- W3120869461 hasConcept C18231593 @default.
- W3120869461 hasConcept C185544564 @default.
- W3120869461 hasConcept C19106626 @default.
- W3120869461 hasConcept C203014093 @default.
- W3120869461 hasConcept C206684579 @default.
- W3120869461 hasConcept C2777761686 @default.
- W3120869461 hasConcept C2777910003 @default.
- W3120869461 hasConcept C501734568 @default.
- W3120869461 hasConcept C502942594 @default.
- W3120869461 hasConcept C509974204 @default.
- W3120869461 hasConcept C54355233 @default.
- W3120869461 hasConcept C552990157 @default.
- W3120869461 hasConcept C71924100 @default.
- W3120869461 hasConcept C86803240 @default.
- W3120869461 hasConceptScore W3120869461C104317684 @default.
- W3120869461 hasConceptScore W3120869461C111337013 @default.
- W3120869461 hasConceptScore W3120869461C121332964 @default.
- W3120869461 hasConceptScore W3120869461C126322002 @default.
- W3120869461 hasConceptScore W3120869461C13514818 @default.
- W3120869461 hasConceptScore W3120869461C137916694 @default.
- W3120869461 hasConceptScore W3120869461C143425029 @default.
- W3120869461 hasConceptScore W3120869461C153911025 @default.
- W3120869461 hasConceptScore W3120869461C178169997 @default.
- W3120869461 hasConceptScore W3120869461C18231593 @default.
- W3120869461 hasConceptScore W3120869461C185544564 @default.
- W3120869461 hasConceptScore W3120869461C19106626 @default.
- W3120869461 hasConceptScore W3120869461C203014093 @default.
- W3120869461 hasConceptScore W3120869461C206684579 @default.
- W3120869461 hasConceptScore W3120869461C2777761686 @default.
- W3120869461 hasConceptScore W3120869461C2777910003 @default.
- W3120869461 hasConceptScore W3120869461C501734568 @default.
- W3120869461 hasConceptScore W3120869461C502942594 @default.
- W3120869461 hasConceptScore W3120869461C509974204 @default.
- W3120869461 hasConceptScore W3120869461C54355233 @default.
- W3120869461 hasConceptScore W3120869461C552990157 @default.
- W3120869461 hasConceptScore W3120869461C71924100 @default.
- W3120869461 hasConceptScore W3120869461C86803240 @default.
- W3120869461 hasLocation W31208694611 @default.
- W3120869461 hasOpenAccess W3120869461 @default.
- W3120869461 hasPrimaryLocation W31208694611 @default.
- W3120869461 hasRelatedWork W17174532 @default.
- W3120869461 hasRelatedWork W21386947 @default.
- W3120869461 hasRelatedWork W2144531 @default.
- W3120869461 hasRelatedWork W26296650 @default.
- W3120869461 hasRelatedWork W29161097 @default.
- W3120869461 hasRelatedWork W29894752 @default.
- W3120869461 hasRelatedWork W34979083 @default.
- W3120869461 hasRelatedWork W37091630 @default.
- W3120869461 hasRelatedWork W7218902 @default.
- W3120869461 hasRelatedWork W8041353 @default.
- W3120869461 isParatext "false" @default.
- W3120869461 isRetracted "false" @default.
- W3120869461 magId "3120869461" @default.
- W3120869461 workType "article" @default.