Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120890309> ?p ?o ?g. }
- W3120890309 abstract "Polyadenylate [poly(A)] tail addition to the 3' end of a wide range of RNAs is a highly conserved modification that plays a central role in cellular RNA function. Elements for nuclear expression (ENEs) are cis-acting RNA elements that stabilize poly(A) tails by sequestering them in RNA triplex structures. A crystal structure of a double ENE from a rice hAT transposon messenger RNA complexed with poly(A)28 at a resolution of 2.89 angstroms reveals multiple modes of interaction with poly(A), including major-groove triple helices, extended minor-groove interactions with RNA double helices, a quintuple-base motif that transitions poly(A) from minor-groove associations to major-groove triple helices, and a poly(A) 3'-end binding pocket. Our findings both expand the repertoire of motifs involved in long-range RNA interactions and provide insights into how polyadenylation can protect an RNA's extreme 3' end." @default.
- W3120890309 created "2021-01-18" @default.
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- W3120890309 date "2021-02-05" @default.
- W3120890309 modified "2023-10-02" @default.
- W3120890309 title "RNA stabilization by a poly(A) tail 3′-end binding pocket and other modes of poly(A)-RNA interaction" @default.
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- W3120890309 doi "https://doi.org/10.1126/science.abe6523" @default.
- W3120890309 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33414189" @default.
- W3120890309 hasPublicationYear "2021" @default.
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