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• W3120908027 abstract "RNA 5-methylcytosine (m5 C) is a prevalent RNA modification in multiple RNA species, including messenger RNAs (mRNAs), transfer RNAs (tRNAs), ribosomal RNAs (rRNAs), and noncoding RNAs (ncRNAs), and broadly distributed from archaea, prokaryotes to eukaryotes. The multiple detecting techniques of m5 C have been developed, such as m5 C-RIP-seq, miCLIP-seq, AZA-IP-seq, RNA-BisSeq, TAWO-seq, and Nanopore sequencing. These high-throughput techniques, combined with corresponding analysis pipeline, provide a precise m5 C landscape contributing to the deciphering of its biological functions. The m5 C modification is distributed along with mRNA and enriched around 5'UTR and 3'UTR, and conserved in tRNAs and rRNAs. It is dynamically regulated by its related enzymes, including methyltransferases (NSUN, DNMT, and TRDMT family members), demethylases (TET families and ALKBH1), and binding proteins (ALYREF and YBX1). So far, accumulative studies have revealed that m5 C participates in a variety of RNA metabolism, including mRNA export, RNA stability, and translation. Depletion of m5 C modification in the organism could cause dysfunction of mitochondria, drawback of stress response, frustration of gametogenesis and embryogenesis, abnormality of neuro and brain development, and has been implicated in cell migration and tumorigenesis. In this review, we provide a comprehensive summary of dynamic regulatory elements of RNA m5 C, including methyltransferases (writers), demethylases (erasers), and binding proteins (readers). We also summarized the related detecting technologies and biological functions of the RNA 5-methylcytosine, and provided future perspectives in m5 C research. This article is categorized under: RNA Processing > RNA Editing and Modification." @default.
• W3120908027 created "2021-01-18" @default.
• W3120908027 creator A5026183055 @default.
• W3120908027 creator A5052037541 @default.
• W3120908027 creator A5067111953 @default.
• W3120908027 creator A5080562594 @default.
• W3120908027 date "2021-01-13" @default.
• W3120908027 modified "2023-10-11" @default.
• W3120908027 title "Dynamic transcriptomic <scp>m⁵C</scp> and its regulatory role in <scp>RNA</scp> processing" @default.
• W3120908027 cites W1271208340 @default.
• W3120908027 cites W1549435121 @default.
• W3120908027 cites W1680192683 @default.
• W3120908027 cites W1832399013 @default.
• W3120908027 cites W1961656476 @default.
• W3120908027 cites W1966620260 @default.
• W3120908027 cites W1970826620 @default.
• W3120908027 cites W1974434508 @default.
• W3120908027 cites W1982704134 @default.
• W3120908027 cites W1984451904 @default.
• W3120908027 cites W2000553262 @default.
• W3120908027 cites W2002654773 @default.
• W3120908027 cites W2005311687 @default.
• W3120908027 cites W2006710298 @default.
• W3120908027 cites W2007982521 @default.
• W3120908027 cites W2009368068 @default.
• W3120908027 cites W2022268135 @default.
• W3120908027 cites W2022770379 @default.
• W3120908027 cites W2022914481 @default.
• W3120908027 cites W2024088186 @default.
• W3120908027 cites W2024497937 @default.
• W3120908027 cites W2025496731 @default.
• W3120908027 cites W2027593734 @default.
• W3120908027 cites W2031388575 @default.
• W3120908027 cites W2044954993 @default.
• W3120908027 cites W2047475913 @default.
• W3120908027 cites W2055735408 @default.
• W3120908027 cites W2058767191 @default.
• W3120908027 cites W2060902122 @default.
• W3120908027 cites W2067022150 @default.
• W3120908027 cites W2067877852 @default.
• W3120908027 cites W2068012865 @default.
• W3120908027 cites W2071930821 @default.
• W3120908027 cites W2076772609 @default.
• W3120908027 cites W2078542955 @default.
• W3120908027 cites W2079840468 @default.
• W3120908027 cites W2082519344 @default.
• W3120908027 cites W2085398950 @default.
• W3120908027 cites W2089556958 @default.
• W3120908027 cites W2089991249 @default.
• W3120908027 cites W2094535741 @default.
• W3120908027 cites W2096767063 @default.
• W3120908027 cites W2104162210 @default.
• W3120908027 cites W2107059185 @default.
• W3120908027 cites W2111647695 @default.
• W3120908027 cites W2114172458 @default.
• W3120908027 cites W2116445953 @default.
• W3120908027 cites W2124800414 @default.
• W3120908027 cites W2129928066 @default.
• W3120908027 cites W2132315340 @default.
• W3120908027 cites W2142215195 @default.
• W3120908027 cites W2143801120 @default.
• W3120908027 cites W2144720261 @default.
• W3120908027 cites W2150673739 @default.
• W3120908027 cites W2164344516 @default.
• W3120908027 cites W2165547003 @default.
• W3120908027 cites W2171593351 @default.
• W3120908027 cites W2231633301 @default.
• W3120908027 cites W2240045277 @default.
• W3120908027 cites W2313190268 @default.
• W3120908027 cites W2406330893 @default.
• W3120908027 cites W2429101410 @default.
• W3120908027 cites W2430983120 @default.
• W3120908027 cites W2468387813 @default.
• W3120908027 cites W2491926383 @default.
• W3120908027 cites W2528074647 @default.
• W3120908027 cites W2528438861 @default.
• W3120908027 cites W2531303593 @default.
• W3120908027 cites W2543761474 @default.
• W3120908027 cites W2547585232 @default.
• W3120908027 cites W2566913469 @default.
• W3120908027 cites W2579273737 @default.
• W3120908027 cites W2582845364 @default.
• W3120908027 cites W2597396396 @default.
• W3120908027 cites W2601757503 @default.
• W3120908027 cites W2606518593 @default.
• W3120908027 cites W2610162195 @default.
• W3120908027 cites W2618440801 @default.
• W3120908027 cites W2625478451 @default.
• W3120908027 cites W2758059175 @default.
• W3120908027 cites W2766067960 @default.
• W3120908027 cites W2784757192 @default.
• W3120908027 cites W2791154320 @default.
• W3120908027 cites W2792917976 @default.
• W3120908027 cites W2793661040 @default.
• W3120908027 cites W2883511460 @default.
• W3120908027 cites W2888347625 @default.
• W3120908027 cites W2896863488 @default.
• W3120908027 cites W2901678079 @default.
• W3120908027 cites W2902132997 @default.
• W3120908027 cites W2905435089 @default.

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