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- W3120932141 endingPage "496" @default.
- W3120932141 startingPage "496" @default.
- W3120932141 abstract "The global rise in type 2 diabetes results from a combination of genetic predisposition with environmental assaults that negatively affect insulin action in peripheral tissues and impair pancreatic β-cell function and survival. Nongenetic heritability of metabolic traits may be an important contributor to the diabetes epidemic. Transfer RNAs (tRNAs) are noncoding RNA molecules that play a crucial role in protein synthesis. tRNAs also have noncanonical functions through which they control a variety of biological processes. Genetic and environmental effects on tRNAs have emerged as novel contributors to the pathogenesis of diabetes. Indeed, altered tRNA aminoacylation, modification, and fragmentation are associated with β-cell failure, obesity, and insulin resistance. Moreover, diet-induced tRNA fragments have been linked with intergenerational inheritance of metabolic traits. Here, we provide a comprehensive review of how perturbations in tRNA biology play a role in the pathogenesis of monogenic and type 2 diabetes." @default.
- W3120932141 created "2021-01-18" @default.
- W3120932141 creator A5040635623 @default.
- W3120932141 creator A5052787913 @default.
- W3120932141 creator A5056936819 @default.
- W3120932141 creator A5080380194 @default.
- W3120932141 date "2021-01-06" @default.
- W3120932141 modified "2023-09-27" @default.
- W3120932141 title "tRNA Biology in the Pathogenesis of Diabetes: Role of Genetic and Environmental Factors" @default.
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