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- W3120932191 abstract "In this paper, novel amide linked 1,2,3-triazoles containing aryloxy derivatives (8a–l) are synthesized via copper-catalyzed one-pot sequential hydroxylation-O-alkylation/click reaction of 2-bromo-N-prop-2-ynyl-benzamides. The products are synthesized in an efficient way in high isolated yields. The synthetic method involves the use of 2-bromo-N-prop-2-ynyl-benzamide and various benzyl halides over a one-pot copper-catalyzed hydroxylation-O-alkylation/Click reaction. The products are characterized by 1H NMR, 13C NMR, mass spectrometry, FT-IR, elemental analysis, melting point, and single crystal X-ray diffraction. In-situ prepared phenol moiety in H2O/DMF as a solventco-solvent system prompted to perform a reaction between benzyl halide and phenols. The step economic feature of the method leads to the synthesis of the products in high isolated yields." @default.
- W3120932191 created "2021-01-18" @default.
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- W3120932191 date "2021-02-01" @default.
- W3120932191 modified "2023-09-23" @default.
- W3120932191 title "Copper-catalyzed one-pot synthesis of amide linked 1,2,3-triazoles bearing aryloxy skeletons" @default.
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- W3120932191 doi "https://doi.org/10.1016/j.tetlet.2020.152765" @default.
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