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- W3120956927 abstract "Acidity is a key player in cancer progression, modelling a microenvironment that prevents immune surveillance and enhances invasiveness, survival, and drug resistance. Here, we demonstrated in spheroids from osteosarcoma cell lines that the exposure to acidosis remarkably caused intracellular lipid droplets accumulation. Lipid accumulation was also detected in sarcoma tissues in close proximity to tumor area that express the acid-related biomarker LAMP2. Acid-induced lipid droplets-accumulation was not functional to a higher energetic request, but rather to cell survival. As a mechanism, we found increased levels of sphingomyelin and secretion of the sphingosine 1-phosphate, and the activation of the associated sphingolipid pathway and the non-canonical NF-ĸB pathway, respectively. Moreover, decreasing sphingosine 1-phosphate levels (S1P) by FTY720 (Fingolimod) impaired acid-induced tumor survival and migration. As a confirmation of the role of S1P in osteosarcoma, we found S1P high circulating levels (30.8 ± 2.5 nmol/mL, n = 17) in the serum of patients. Finally, when we treated osteosarcoma xenografts with FTY720 combined with low-serine/glycine diet, both lipid accumulation (as measured by magnetic resonance imaging) and tumor growth were greatly inhibited. For the first time, this study profiles the lipidomic rearrangement of sarcomas under acidic conditions, suggesting the use of anti-S1P strategies in combination with standard chemotherapy." @default.
- W3120956927 created "2021-01-18" @default.
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- W3120956927 date "2021-01-15" @default.
- W3120956927 modified "2023-10-05" @default.
- W3120956927 title "Exploring Metabolic Adaptations to the Acidic Microenvironment of Osteosarcoma Cells Unveils Sphingosine 1-Phosphate as a Valuable Therapeutic Target" @default.
- W3120956927 cites W121477089 @default.
- W3120956927 cites W1758244037 @default.
- W3120956927 cites W1830948261 @default.
- W3120956927 cites W1968380935 @default.
- W3120956927 cites W1969064400 @default.
- W3120956927 cites W1971353685 @default.
- W3120956927 cites W1980181091 @default.
- W3120956927 cites W1980568044 @default.
- W3120956927 cites W1981233558 @default.
- W3120956927 cites W1983079076 @default.
- W3120956927 cites W1990331048 @default.
- W3120956927 cites W1992605698 @default.
- W3120956927 cites W1996221314 @default.
- W3120956927 cites W2003652177 @default.
- W3120956927 cites W2007505836 @default.
- W3120956927 cites W2017180312 @default.
- W3120956927 cites W2022589671 @default.
- W3120956927 cites W2033474014 @default.
- W3120956927 cites W2035310767 @default.
- W3120956927 cites W2036087370 @default.
- W3120956927 cites W2037064466 @default.
- W3120956927 cites W2039050740 @default.
- W3120956927 cites W2042075770 @default.
- W3120956927 cites W2046965677 @default.
- W3120956927 cites W2054200174 @default.
- W3120956927 cites W2068050569 @default.
- W3120956927 cites W2079585822 @default.
- W3120956927 cites W2085972914 @default.
- W3120956927 cites W2086728216 @default.
- W3120956927 cites W2092608421 @default.
- W3120956927 cites W2096769282 @default.
- W3120956927 cites W2099667863 @default.
- W3120956927 cites W2105514151 @default.
- W3120956927 cites W2108091182 @default.
- W3120956927 cites W2110388058 @default.
- W3120956927 cites W2116881244 @default.
- W3120956927 cites W2122713287 @default.
- W3120956927 cites W2123779991 @default.
- W3120956927 cites W2126524529 @default.
- W3120956927 cites W2130503287 @default.
- W3120956927 cites W2141809186 @default.
- W3120956927 cites W2145876349 @default.
- W3120956927 cites W2149902856 @default.
- W3120956927 cites W2162605849 @default.
- W3120956927 cites W2181017482 @default.
- W3120956927 cites W2194099451 @default.
- W3120956927 cites W2195804825 @default.
- W3120956927 cites W2265836483 @default.
- W3120956927 cites W2270643969 @default.
- W3120956927 cites W2283847485 @default.
- W3120956927 cites W2345133451 @default.
- W3120956927 cites W2406009985 @default.
- W3120956927 cites W2504361340 @default.
- W3120956927 cites W2515247624 @default.
- W3120956927 cites W2519340364 @default.
- W3120956927 cites W2551599370 @default.
- W3120956927 cites W2557383678 @default.
- W3120956927 cites W2568514472 @default.
- W3120956927 cites W2571554990 @default.
- W3120956927 cites W2579141981 @default.
- W3120956927 cites W2605923420 @default.
- W3120956927 cites W2606111706 @default.
- W3120956927 cites W2607135274 @default.
- W3120956927 cites W2729569907 @default.
- W3120956927 cites W2755677304 @default.
- W3120956927 cites W2757027592 @default.
- W3120956927 cites W2767576903 @default.
- W3120956927 cites W2769015380 @default.
- W3120956927 cites W2769383666 @default.
- W3120956927 cites W2770916293 @default.
- W3120956927 cites W2789303432 @default.
- W3120956927 cites W2794197589 @default.
- W3120956927 cites W2803664483 @default.
- W3120956927 cites W2805716021 @default.
- W3120956927 cites W2886202817 @default.
- W3120956927 cites W2889378732 @default.
- W3120956927 cites W2889913954 @default.
- W3120956927 cites W2902377196 @default.
- W3120956927 cites W2913305959 @default.
- W3120956927 cites W2917145534 @default.