FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120964934> ?p ?o ?g. }

• W3120964934 abstract "Age and gender are two important factors that may influence the function and structure of the retina and its susceptibility to retinal diseases. The aim of this study was to delineate the influence that biological sex and age exert on the retinal structural and ultrastructural changes in mice and to identify the age-related miRNA dysregulation profiles in the retina by gender. Experiments were undertaken on male and female Balb/c aged 24 months (approximately 75–85 years in humans) compared to the control (3 months). The retinas were analyzed by histology, transmission electron microscopy, and age-related miRNA expression profile analysis. Retinas of both sexes showed a steady decline in retinal thickness as follows: photoreceptor (PS) and outer layers ( p &lt; 0.01 for the aged male vs. control; p &lt; 0.05 for the aged female vs. control); the inner retinal layers were significantly affected by the aging process in the males ( p &lt; 0.01) but not in the aged females. Electron microscopy revealed more abnormalities which involve the retinal pigment epithelium (RPE) and Bruch’s membrane, outer and inner layers, vascular changes, deposits of amorphous materials, and accumulation of lipids or lipofuscins. Age-related miRNAs, miR-27a-3p ( p &lt; 0.01), miR-27b-3p ( p &lt; 0.05), and miR-20a-5p ( p &lt; 0.05) were significantly up-regulated in aged male mice compared to the controls, whereas miR-20b-5p was significantly down-regulated in aged male ( p &lt; 0.05) and female mice ( p &lt; 0.05) compared to the respective controls. miR-27a-3p (5.00 fold; p &lt; 0.01) and miR-27b (7.58 fold; p &lt; 0.01) were significantly up-regulated in aged male mice vs. aged female mice, whereas miR-20b-5p (−2.10 fold; p &lt; 0.05) was significantly down-regulated in aged male mice vs. aged female mice. Interestingly, miR-27a-3p, miR-27b-3p, miR-20a-5p, and miR-20b-5p expressions significantly correlated with the thickness of the retinal PS layer ( p &lt; 0.01), retinal outer layers ( p &lt; 0.01), and Bruch’s membrane ( p &lt; 0.01). Our results showed that biological sex can influence the structure and function of the retina upon aging, suggesting that this difference may be underlined by the dysregulation of age-related mi-RNAs." @default.
• W3120964934 created "2021-01-18" @default.
• W3120964934 creator A5019064842 @default.
• W3120964934 creator A5033023694 @default.
• W3120964934 creator A5037607405 @default.
• W3120964934 creator A5041560971 @default.
• W3120964934 creator A5043435630 @default.
• W3120964934 creator A5057251848 @default.
• W3120964934 creator A5058485837 @default.
• W3120964934 creator A5068745299 @default.
• W3120964934 creator A5068778175 @default.
• W3120964934 creator A5077782340 @default.
• W3120964934 creator A5087453313 @default.
• W3120964934 date "2021-01-13" @default.
• W3120964934 modified "2023-10-13" @default.
• W3120964934 title "Changes in Retinal Structure and Ultrastructure in the Aged Mice Correlate With Differences in the Expression of Selected Retinal miRNAs" @default.
• W3120964934 cites W144423133 @default.
• W3120964934 cites W1592657292 @default.
• W3120964934 cites W1606853417 @default.
• W3120964934 cites W1771974095 @default.
• W3120964934 cites W1927574214 @default.
• W3120964934 cites W1963821949 @default.
• W3120964934 cites W1964119221 @default.
• W3120964934 cites W1966276445 @default.
• W3120964934 cites W1966846271 @default.
• W3120964934 cites W1970140546 @default.
• W3120964934 cites W1971589241 @default.
• W3120964934 cites W1971975033 @default.
• W3120964934 cites W1972444897 @default.
• W3120964934 cites W1976288530 @default.
• W3120964934 cites W1977620941 @default.
• W3120964934 cites W1977670584 @default.
• W3120964934 cites W1983063825 @default.
• W3120964934 cites W1985663227 @default.
• W3120964934 cites W1986119451 @default.
• W3120964934 cites W1987734048 @default.
• W3120964934 cites W1987824810 @default.
• W3120964934 cites W1988180448 @default.
• W3120964934 cites W1994025305 @default.
• W3120964934 cites W2001522320 @default.
• W3120964934 cites W2006862162 @default.
• W3120964934 cites W2008213605 @default.
• W3120964934 cites W2009547844 @default.
• W3120964934 cites W2017787558 @default.
• W3120964934 cites W2018197169 @default.
• W3120964934 cites W2022823113 @default.
• W3120964934 cites W2024856870 @default.
• W3120964934 cites W2025686193 @default.
• W3120964934 cites W2026386627 @default.
• W3120964934 cites W2036282277 @default.
• W3120964934 cites W2038436445 @default.
• W3120964934 cites W2040853816 @default.
• W3120964934 cites W2045725250 @default.
• W3120964934 cites W2047355346 @default.
• W3120964934 cites W2048140541 @default.
• W3120964934 cites W2053388053 @default.
• W3120964934 cites W2055541535 @default.
• W3120964934 cites W2059460589 @default.
• W3120964934 cites W2065288017 @default.
• W3120964934 cites W2067707240 @default.
• W3120964934 cites W2067825692 @default.
• W3120964934 cites W2077039279 @default.
• W3120964934 cites W2077366389 @default.
• W3120964934 cites W2078340265 @default.
• W3120964934 cites W2081361584 @default.
• W3120964934 cites W2086764123 @default.
• W3120964934 cites W2088432960 @default.
• W3120964934 cites W2091176696 @default.
• W3120964934 cites W2092883947 @default.
• W3120964934 cites W2101548423 @default.
• W3120964934 cites W2105495395 @default.
• W3120964934 cites W2107089046 @default.
• W3120964934 cites W2127342236 @default.
• W3120964934 cites W2127507482 @default.
• W3120964934 cites W2134386137 @default.
• W3120964934 cites W2138007782 @default.
• W3120964934 cites W2138952087 @default.
• W3120964934 cites W2141648382 @default.
• W3120964934 cites W2144839999 @default.
• W3120964934 cites W2147257512 @default.
• W3120964934 cites W2147322584 @default.
• W3120964934 cites W2149925846 @default.
• W3120964934 cites W2150476698 @default.
• W3120964934 cites W2158797406 @default.
• W3120964934 cites W2162415186 @default.
• W3120964934 cites W2168946799 @default.
• W3120964934 cites W2186579820 @default.
• W3120964934 cites W2213421734 @default.
• W3120964934 cites W2232635222 @default.
• W3120964934 cites W2310003175 @default.
• W3120964934 cites W2337889145 @default.
• W3120964934 cites W2521207889 @default.
• W3120964934 cites W2598073024 @default.
• W3120964934 cites W2599586899 @default.
• W3120964934 cites W2599844701 @default.
• W3120964934 cites W2744160143 @default.
• W3120964934 cites W2794259284 @default.
• W3120964934 cites W2799986334 @default.
• W3120964934 cites W2801329157 @default.
• W3120964934 cites W2847321611 @default.

• next