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- W3120986071 abstract "BACKGROUND: The objective of this study was to evaluate the safety of liver transaminases monitoring every 12weeks in patients with inflammatory connective tissue disorders who are treated with methotrexate (MTX).METHODS: In a retrospective study, the data from the rheumatic patients receiving MTX were analyzed. Alanineaminotransferase (ALT) and aspartate aminotransferase (AST) were measured at baseline and every 12 weeks. Thepatients were classified according to their ALT and AST levels as no change, 1-2 times increase, 2-3 times increase, andmore than 3 times increase in their ALT or AST levels. Based on the physician’s decision on the dose of MTX, thepatients were classified into no change in MTX dose, decrease in MTX dose, and discontinuation of MTX. Based on thephysician’s final decision about the continuation of MTX, the patients were classified into one of the following groups:continuation of MTX without MTX dose reduction; MTX dose reduction; MTX discontinuation due to livercomplication; and MTX discontinuation due to other reasons.RESULTS: A total of 809 patients who were on MTX were included in the study. The mean follow-up duration and themean duration of treatment with MTX were 31.22 and 19.76 months, respectively. The mean accumulation dose ofMTX was 865.85 mg. Due to the increase in the level of transaminases in 26 (3.2%) of the patients the dose of MTXwas reduced, and in 9 (1.1%) cases it was temporarily discontinued. During the follow-up of the patients with elevatedtransaminases levels, they returned to normal limits in 90 (99.5%) of the patients; however, in 4 of the cases (0.5%)they remained elevated and MTX was discontinued. The probability of the patients remaining on MTX for 5 yearswithout discontinuation for liver complications was 98.5%.CONCLUSIONS: Liver transaminases monitoring every 12 weeks for MTX treated patients is safe." @default.
- W3120986071 created "2021-01-18" @default.
- W3120986071 creator A5087461425 @default.
- W3120986071 date "2015-01-01" @default.
- W3120986071 modified "2023-09-23" @default.
- W3120986071 title "Safety of liver function monitoring every 3 months in patients treated with low dose methotrexate" @default.
- W3120986071 hasPublicationYear "2015" @default.
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