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• W3120991763 abstract "Abstract Study Objectives Aging is associated with detrimental changes in sleep physiology, a process accelerated in Alzheimer’s disease. Fine-tuned temporal interactions of non-rapid eye movement slow oscillations and spindles were shown to be particularly important for memory consolidation, and to deteriorate in healthy older adults. Whether this oscillatory interaction further decline in early stages of Alzheimer’s disease such as mild cognitive impairment has not been investigated to date, but may have important therapeutic implications. Methods Here, we assessed differences in sleep architecture and memory-relevant slow oscillation, sleep spindles and their functional coupling during a 90-min nap between healthy young and older adults, and in older patients with mild cognitive impairment. Furthermore, associations of nap-sleep characteristics with sleep-dependent memory performance change were evaluated. Results We found significant differences between young and older healthy adults, and between young adults and patients with mild cognitive impairment, but not between healthy older adults and patients for several sleep metrics, including slow oscillation-spindle coupling. Moreover, sleep-dependent retention of verbal memories was significantly higher in young healthy adults versus older adults with and without mild cognitive impairment, but no difference between the two older groups was observed. Associations with sleep metrics were only found for pre-nap memory performances. Conclusions In conclusion, our results indicate changes in nap sleep physiology and sleep-related memory consolidation in older adults with and without mild cognitive impairment. Thus, interventions targeted at improving sleep physiology may help to reduce memory decline in both groups, but our study does not indicate additional benefits for patients with mild cognitive impairment. Clinical Trail Registration Effects of Brain Stimulation During Daytime Nap on Memory Consolidation in Younger, Healthy Subjects: https://clinicaltrials.gov/ct2/show/NCT01840865; NCT01840865. Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Older Adults; https://clinicaltrials.gov/ct2/show/study/NCT01840839?term=01840839&draw=2&rank=1; NCT01840839. Effects of Brain Stimulation During a Daytime Nap on Memory Consolidation in Patients With Mild Cognitive Impairment; https://clinicaltrials.gov/ct2/show/NCT01782365?term=01782365&draw=2&rank=1; NCT01782365." @default.
• W3120991763 created "2021-01-18" @default.
• W3120991763 creator A5001451500 @default.
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• W3120991763 date "2021-01-06" @default.
• W3120991763 modified "2023-10-16" @default.
• W3120991763 title "Memory-relevant nap sleep physiology in healthy and pathological aging" @default.
• W3120991763 cites W1545353838 @default.
• W3120991763 cites W1858906879 @default.
• W3120991763 cites W1874386989 @default.
• W3120991763 cites W1897507705 @default.
• W3120991763 cites W1957460466 @default.
• W3120991763 cites W197066864 @default.
• W3120991763 cites W1975136983 @default.
• W3120991763 cites W1978420618 @default.
• W3120991763 cites W1983182638 @default.
• W3120991763 cites W1987662024 @default.
• W3120991763 cites W1987807715 @default.
• W3120991763 cites W1992999217 @default.
• W3120991763 cites W2000652061 @default.
• W3120991763 cites W2005813957 @default.
• W3120991763 cites W2007092083 @default.
• W3120991763 cites W2008699078 @default.
• W3120991763 cites W2013563458 @default.
• W3120991763 cites W2015535239 @default.
• W3120991763 cites W2015603515 @default.
• W3120991763 cites W2016787780 @default.
• W3120991763 cites W2028436804 @default.
• W3120991763 cites W2030353060 @default.
• W3120991763 cites W2033411327 @default.
• W3120991763 cites W2035490031 @default.
• W3120991763 cites W2038309664 @default.
• W3120991763 cites W2038369901 @default.
• W3120991763 cites W2054905216 @default.
• W3120991763 cites W2071039532 @default.
• W3120991763 cites W2074983884 @default.
• W3120991763 cites W2076136875 @default.
• W3120991763 cites W2076327464 @default.
• W3120991763 cites W2078929245 @default.
• W3120991763 cites W2081103834 @default.
• W3120991763 cites W2084108448 @default.
• W3120991763 cites W2084108509 @default.
• W3120991763 cites W2084617650 @default.
• W3120991763 cites W2102656701 @default.
• W3120991763 cites W2102988199 @default.
• W3120991763 cites W2114173046 @default.
• W3120991763 cites W2119463290 @default.
• W3120991763 cites W2125579095 @default.
• W3120991763 cites W2131436025 @default.
• W3120991763 cites W2131973169 @default.
• W3120991763 cites W2137418393 @default.
• W3120991763 cites W2137614309 @default.
• W3120991763 cites W2139881480 @default.
• W3120991763 cites W2143790126 @default.
• W3120991763 cites W2144059033 @default.
• W3120991763 cites W2151487996 @default.
• W3120991763 cites W2151528679 @default.
• W3120991763 cites W2161150631 @default.
• W3120991763 cites W2161166547 @default.
• W3120991763 cites W2163225965 @default.
• W3120991763 cites W2166062952 @default.
• W3120991763 cites W2166073443 @default.
• W3120991763 cites W2168645178 @default.
• W3120991763 cites W2169806547 @default.
• W3120991763 cites W2217430143 @default.
• W3120991763 cites W2218418953 @default.
• W3120991763 cites W2297783832 @default.
• W3120991763 cites W2302544156 @default.
• W3120991763 cites W2343960448 @default.
• W3120991763 cites W2403111963 @default.
• W3120991763 cites W2440154114 @default.
• W3120991763 cites W2472440797 @default.
• W3120991763 cites W2587736287 @default.
• W3120991763 cites W2593397540 @default.
• W3120991763 cites W2605277320 @default.
• W3120991763 cites W2650613126 @default.
• W3120991763 cites W2775812132 @default.
• W3120991763 cites W2798054687 @default.
• W3120991763 cites W2806383879 @default.
• W3120991763 cites W2910774779 @default.
• W3120991763 cites W2922230243 @default.
• W3120991763 cites W2951101464 @default.
• W3120991763 cites W2952560444 @default.
• W3120991763 cites W2967042025 @default.
• W3120991763 cites W2976039904 @default.
• W3120991763 cites W4292994367 @default.
• W3120991763 doi "https://doi.org/10.1093/sleep/zsab002" @default.
• W3120991763 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33406266" @default.
• W3120991763 hasPublicationYear "2021" @default.
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