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- W3120997614 abstract "Valosin-containing protein (VCP/p97) is a member of the conserved type II AAA+ (ATPases associated with diverse cellular activities) family of proteins with multiple biological functions, especially in protein homeostasis. Mutations in VCP/p97 are reportedly related to unique autosomal dominant diseases, which may worsen cardiac function. Although the structure of VCP/p97 has been clearly characterized, with reports of high abundance in the heart, research focusing on the molecular mechanisms underpinning the roles of VCP/p97 in the cardiovascular system has been recently undertaken over the past decades. Recent studies have shown that VCP/p97 deficiency affects myocardial fibers and induces heart failure, while overexpression of VCP/p97 eliminates ischemia/reperfusion injury and relieves pathological cardiac hypertrophy caused by cardiac pressure overload, which is related to changes in the mitochondria and calcium overload. However, certain studies have drawn opposing conclusions, including the mitigation of ischemia/reperfusion injury via inhibition of VCP/p97 ATPase activity. Nevertheless, these emerging studies shed light on the role of VCP/p97 and its therapeutic potential in cardiovascular diseases. In other words, VCP/p97 may be involved in the development of cardiovascular disease, and is anticipated to be a new therapeutic target. This review summarizes current findings regarding VCP/p97 in the cardiovascular system for the first time, and discusses the role of VCP/p97 in cardiovascular disease." @default.
- W3120997614 created "2021-01-18" @default.
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- W3120997614 date "2021-01-13" @default.
- W3120997614 modified "2023-10-18" @default.
- W3120997614 title "Emerging role of VCP/p97 in cardiovascular diseases: novel insights and therapeutic opportunities" @default.
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- W3120997614 cites W1977455683 @default.
- W3120997614 cites W1989434611 @default.
- W3120997614 cites W1996688673 @default.
- W3120997614 cites W1996718698 @default.
- W3120997614 cites W1997023449 @default.
- W3120997614 cites W1997559284 @default.
- W3120997614 cites W2009498504 @default.
- W3120997614 cites W2025269346 @default.
- W3120997614 cites W2028957334 @default.
- W3120997614 cites W2035902226 @default.
- W3120997614 cites W2037008545 @default.
- W3120997614 cites W2042752473 @default.
- W3120997614 cites W2043178567 @default.
- W3120997614 cites W2046690157 @default.
- W3120997614 cites W2050743143 @default.
- W3120997614 cites W2051395985 @default.
- W3120997614 cites W2056607803 @default.
- W3120997614 cites W2087351164 @default.
- W3120997614 cites W2092951319 @default.
- W3120997614 cites W2095192240 @default.
- W3120997614 cites W2096161049 @default.
- W3120997614 cites W2101307289 @default.
- W3120997614 cites W2103959299 @default.
- W3120997614 cites W2106922430 @default.
- W3120997614 cites W2116295762 @default.
- W3120997614 cites W2149799872 @default.
- W3120997614 cites W2155537040 @default.
- W3120997614 cites W2155971660 @default.
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- W3120997614 cites W2212600780 @default.
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- W3120997614 cites W2371948111 @default.
- W3120997614 cites W2392382529 @default.
- W3120997614 cites W2395292855 @default.
- W3120997614 cites W2415715899 @default.
- W3120997614 cites W2461485730 @default.
- W3120997614 cites W2474894018 @default.
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- W3120997614 cites W2532244501 @default.
- W3120997614 cites W2533656436 @default.
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- W3120997614 cites W2742501476 @default.
- W3120997614 cites W2742837250 @default.
- W3120997614 cites W2756105534 @default.
- W3120997614 cites W2769061006 @default.
- W3120997614 cites W2779928931 @default.
- W3120997614 cites W2788420485 @default.
- W3120997614 cites W2789055329 @default.
- W3120997614 cites W2790656775 @default.
- W3120997614 cites W2801346090 @default.
- W3120997614 cites W2802028464 @default.
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- W3120997614 cites W2966555630 @default.
- W3120997614 cites W2979237529 @default.
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- W3120997614 doi "https://doi.org/10.1042/bst20200981" @default.
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- W3120997614 hasPublicationYear "2021" @default.
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