FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120998631> ?p ?o ?g. }

• W3120998631 abstract "Abstract Cellular senescence is emerging as the causal nexus of aging, and its potential modulators present an effective strategy to counter age-related morbidity. The current study profiled the extent of cellular senescence in different organs of mice at four different time-points of lifespan, and explored the influence of epigallocatechin gallate (EGCG) consumption in impacting multiple aspects of aging biology. We report that adipose and intestinal tissues are highly vulnerable to cellular senescence as evident by age-associated increase in DNA damage response, activation of cell cycle inhibitors (p53/p21) and induction of SASP (p38MAPK/NF-κB/Cox-2). Further, a distinct modulation of nutrient signaling pathway mediators (AMPK/Akt/SIRT3 and 5), and a decrease in autophagy effectors was also observed in aging animals. Systemic inflamm-aging markers (TNF-α/IL-lβ) and splenic CD4/CD8 ratio increased with age, while NK cell population decreased. Metagenomic analyses revealed age-related decrease in the diversity of microbial species while an increase in the abundance of various pathogenic bacterial genera was also observed. Long term EGCG consumption enhanced lifespan of animals by attenuating markers of DNA damage, cell cycle inhibitors and SASP in adipose, intestine and liver tissue. Mechanistically, EGCG inhibited the activation of AMPK and Akt and enhanced mitochondrial SIRT3 and SIRT5 expression, as well as autophagic response in adipose and intestinal tissues. Systemic presence of inflamm-aging markers decreased while expression of T cell immune response regulator CD69 increased in EGCG fed animals. EGCG also improved age-related decrease in the diversity of microbial species and suppressed the growth of pathogenic microbes. In short, our results provide compelling evidence that post-mitotic adipose tissue is a major site of cellular senescence and SASP activation, and that chronic EGCG consumption can influence several aspects of aging and senescence resulting in improved organismal healthspan and lifespan." @default.
• W3120998631 created "2021-01-18" @default.
• W3120998631 creator A5012994123 @default.
• W3120998631 creator A5026467615 @default.
• W3120998631 creator A5038687014 @default.
• W3120998631 creator A5070862153 @default.
• W3120998631 creator A5091097264 @default.
• W3120998631 date "2021-01-04" @default.
• W3120998631 modified "2023-09-25" @default.
• W3120998631 title "Long term consumption of green tea EGCG enhances healthspan and lifespan in mice by mitigating multiple aspects of cellular senescence in mitotic and post-mitotic tissues, gut dysbiosis and immunosenescence" @default.
• W3120998631 cites W1964041047 @default.
• W3120998631 cites W1981275481 @default.
• W3120998631 cites W1982348992 @default.
• W3120998631 cites W1982475751 @default.
• W3120998631 cites W1992268549 @default.
• W3120998631 cites W1997079130 @default.
• W3120998631 cites W2007872313 @default.
• W3120998631 cites W2018280811 @default.
• W3120998631 cites W2027350090 @default.
• W3120998631 cites W2052244692 @default.
• W3120998631 cites W2062265555 @default.
• W3120998631 cites W2064871936 @default.
• W3120998631 cites W2069519394 @default.
• W3120998631 cites W2070325805 @default.
• W3120998631 cites W2070570719 @default.
• W3120998631 cites W2087857618 @default.
• W3120998631 cites W2115852450 @default.
• W3120998631 cites W2128681720 @default.
• W3120998631 cites W2130458932 @default.
• W3120998631 cites W2132406938 @default.
• W3120998631 cites W2136261363 @default.
• W3120998631 cites W2147030667 @default.
• W3120998631 cites W2148651797 @default.
• W3120998631 cites W2266290735 @default.
• W3120998631 cites W2316887884 @default.
• W3120998631 cites W2410474683 @default.
• W3120998631 cites W2426149297 @default.
• W3120998631 cites W2597876152 @default.
• W3120998631 cites W2606745291 @default.
• W3120998631 cites W2758757285 @default.
• W3120998631 cites W2765839056 @default.
• W3120998631 cites W2787219541 @default.
• W3120998631 cites W2790749994 @default.
• W3120998631 cites W2793767436 @default.
• W3120998631 cites W2801266108 @default.
• W3120998631 cites W2804257223 @default.
• W3120998631 cites W2901275685 @default.
• W3120998631 cites W2924101029 @default.
• W3120998631 cites W2950304894 @default.
• W3120998631 cites W2951013990 @default.
• W3120998631 cites W2968954657 @default.
• W3120998631 cites W2991917435 @default.
• W3120998631 cites W3005953698 @default.
• W3120998631 cites W3005967985 @default.
• W3120998631 cites W3009378564 @default.
• W3120998631 cites W3011483812 @default.
• W3120998631 cites W3011574159 @default.
• W3120998631 cites W3049347810 @default.
• W3120998631 cites W3093840514 @default.
• W3120998631 cites W4293247451 @default.
• W3120998631 doi "https://doi.org/10.1101/2021.01.01.425058" @default.
• W3120998631 hasPublicationYear "2021" @default.
• W3120998631 type Work @default.
• W3120998631 sameAs 3120998631 @default.
• W3120998631 citedByCount "4" @default.
• W3120998631 countsByYear W31209986312021 @default.
• W3120998631 countsByYear W31209986312022 @default.
• W3120998631 crossrefType "posted-content" @default.
• W3120998631 hasAuthorship W3120998631A5012994123 @default.
• W3120998631 hasAuthorship W3120998631A5026467615 @default.
• W3120998631 hasAuthorship W3120998631A5038687014 @default.
• W3120998631 hasAuthorship W3120998631A5070862153 @default.
• W3120998631 hasAuthorship W3120998631A5091097264 @default.
• W3120998631 hasBestOaLocation W31209986311 @default.
• W3120998631 hasConcept C143425029 @default.
• W3120998631 hasConcept C184235292 @default.
• W3120998631 hasConcept C190283241 @default.
• W3120998631 hasConcept C203014093 @default.
• W3120998631 hasConcept C203522944 @default.
• W3120998631 hasConcept C2779056147 @default.
• W3120998631 hasConcept C2780124434 @default.
• W3120998631 hasConcept C502942594 @default.
• W3120998631 hasConcept C522857546 @default.
• W3120998631 hasConcept C552990157 @default.
• W3120998631 hasConcept C55493867 @default.
• W3120998631 hasConcept C86803240 @default.
• W3120998631 hasConcept C8891405 @default.
• W3120998631 hasConcept C95444343 @default.
• W3120998631 hasConcept C97029542 @default.
• W3120998631 hasConceptScore W3120998631C143425029 @default.
• W3120998631 hasConceptScore W3120998631C184235292 @default.
• W3120998631 hasConceptScore W3120998631C190283241 @default.
• W3120998631 hasConceptScore W3120998631C203014093 @default.
• W3120998631 hasConceptScore W3120998631C203522944 @default.
• W3120998631 hasConceptScore W3120998631C2779056147 @default.
• W3120998631 hasConceptScore W3120998631C2780124434 @default.
• W3120998631 hasConceptScore W3120998631C502942594 @default.
• W3120998631 hasConceptScore W3120998631C522857546 @default.
• W3120998631 hasConceptScore W3120998631C552990157 @default.
• W3120998631 hasConceptScore W3120998631C55493867 @default.

• next