FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3120999330> ?p ?o ?g. }

• W3120999330 abstract "Postoperative ileus (POI) is triggered by an innate immune response in the muscularis externa (ME) and is accompanied by bacterial translocation. Bacteria can trigger an innate immune response via toll-like receptor (TLR) activation, but the latter’s contribution to POI has been disproved for several TLRs, including TLR2 and TLR4. Herein we investigated the role of double-stranded RNA detection via TLR3 and TIR-domain-containing adapter-inducing interferon-β (TRIF) signaling pathway in POI. POI was induced by small bowel intestinal manipulation in wt, TRIF -/- , TLR3 -/- , type I interferon receptor -/- and interferon-β reporter mice, all on C57BL/6 background, and POI severity was quantified by gene expression analysis, gastrointestinal transit and leukocyte extravasation into the ME. TRIF/TLR3 deficiency reduced postoperative ME inflammation and prevented POI. With bone marrow transplantation, RNA-sequencing, flow cytometry and immunohistochemistry we revealed a distinct TLR3-expressing radio-resistant MHCII hi CX3CR1 - IBA-1 + resident macrophage population within the deep myenteric plexus. TLR3 deficiency in these cells, but not in MHCII hi CX3CR1 + macrophages, reduced cytokine expression in POI. While this might not be an exclusive macrophage-privileged pathway, the TLR3/TRIF axis contributes to proinflammatory cytokine production in MHCII hi CX3CR1 - IBA-1 + macrophages during POI. Deficiency in TLR3/TRIF protects mice from POI. These data suggest that TLR3 antagonism may prevent POI in humans." @default.
• W3120999330 created "2021-01-18" @default.
• W3120999330 creator A5000887206 @default.
• W3120999330 creator A5008688584 @default.
• W3120999330 creator A5009596422 @default.
• W3120999330 creator A5020377284 @default.
• W3120999330 creator A5026495273 @default.
• W3120999330 creator A5027128135 @default.
• W3120999330 creator A5051853913 @default.
• W3120999330 creator A5067705150 @default.
• W3120999330 creator A5068482237 @default.
• W3120999330 creator A5073445890 @default.
• W3120999330 creator A5077529752 @default.
• W3120999330 creator A5090900617 @default.
• W3120999330 date "2021-01-13" @default.
• W3120999330 modified "2023-09-26" @default.
• W3120999330 title "A Population of Radio-Resistant Macrophages in the Deep Myenteric Plexus Contributes to Postoperative Ileus Via Toll-Like Receptor 3 Signaling" @default.
• W3120999330 cites W1515273152 @default.
• W3120999330 cites W1595293335 @default.
• W3120999330 cites W1843467217 @default.
• W3120999330 cites W1950305586 @default.
• W3120999330 cites W1972876165 @default.
• W3120999330 cites W1977325109 @default.
• W3120999330 cites W1986178107 @default.
• W3120999330 cites W1997013958 @default.
• W3120999330 cites W2004428852 @default.
• W3120999330 cites W2004829503 @default.
• W3120999330 cites W2010548727 @default.
• W3120999330 cites W2012290449 @default.
• W3120999330 cites W2013067182 @default.
• W3120999330 cites W2020173029 @default.
• W3120999330 cites W2030665562 @default.
• W3120999330 cites W2035250169 @default.
• W3120999330 cites W2044602350 @default.
• W3120999330 cites W2059805321 @default.
• W3120999330 cites W2066617961 @default.
• W3120999330 cites W2072566431 @default.
• W3120999330 cites W2072751712 @default.
• W3120999330 cites W2076361525 @default.
• W3120999330 cites W2079946840 @default.
• W3120999330 cites W2094617951 @default.
• W3120999330 cites W2108639003 @default.
• W3120999330 cites W2109491705 @default.
• W3120999330 cites W2112663559 @default.
• W3120999330 cites W2126263479 @default.
• W3120999330 cites W2130421043 @default.
• W3120999330 cites W2141941378 @default.
• W3120999330 cites W2149330714 @default.
• W3120999330 cites W2159950118 @default.
• W3120999330 cites W2161057248 @default.
• W3120999330 cites W2164150624 @default.
• W3120999330 cites W2168390323 @default.
• W3120999330 cites W2179438025 @default.
• W3120999330 cites W2197124664 @default.
• W3120999330 cites W2232938630 @default.
• W3120999330 cites W2323326409 @default.
• W3120999330 cites W2556128087 @default.
• W3120999330 cites W2590657832 @default.
• W3120999330 cites W2690953659 @default.
• W3120999330 cites W2781139158 @default.
• W3120999330 cites W2801661484 @default.
• W3120999330 cites W2889222907 @default.
• W3120999330 cites W2889537463 @default.
• W3120999330 cites W2895890124 @default.
• W3120999330 cites W2913714888 @default.
• W3120999330 cites W2962812335 @default.
• W3120999330 doi "https://doi.org/10.3389/fimmu.2020.581111" @default.
• W3120999330 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7838642" @default.
• W3120999330 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33519804" @default.
• W3120999330 hasPublicationYear "2021" @default.
• W3120999330 type Work @default.
• W3120999330 sameAs 3120999330 @default.
• W3120999330 citedByCount "6" @default.
• W3120999330 countsByYear W31209993302022 @default.
• W3120999330 countsByYear W31209993302023 @default.
• W3120999330 crossrefType "journal-article" @default.
• W3120999330 hasAuthorship W3120999330A5000887206 @default.
• W3120999330 hasAuthorship W3120999330A5008688584 @default.
• W3120999330 hasAuthorship W3120999330A5009596422 @default.
• W3120999330 hasAuthorship W3120999330A5020377284 @default.
• W3120999330 hasAuthorship W3120999330A5026495273 @default.
• W3120999330 hasAuthorship W3120999330A5027128135 @default.
• W3120999330 hasAuthorship W3120999330A5051853913 @default.
• W3120999330 hasAuthorship W3120999330A5067705150 @default.
• W3120999330 hasAuthorship W3120999330A5068482237 @default.
• W3120999330 hasAuthorship W3120999330A5073445890 @default.
• W3120999330 hasAuthorship W3120999330A5077529752 @default.
• W3120999330 hasAuthorship W3120999330A5090900617 @default.
• W3120999330 hasBestOaLocation W31209993301 @default.
• W3120999330 hasConcept C136449434 @default.
• W3120999330 hasConcept C164027704 @default.
• W3120999330 hasConcept C203014093 @default.
• W3120999330 hasConcept C2776070231 @default.
• W3120999330 hasConcept C2776709828 @default.
• W3120999330 hasConcept C2776914184 @default.
• W3120999330 hasConcept C2778420691 @default.
• W3120999330 hasConcept C2781236682 @default.
• W3120999330 hasConcept C2908647359 @default.
• W3120999330 hasConcept C43929388 @default.
• W3120999330 hasConcept C502942594 @default.

• next