FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121013252> ?p ?o ?g. }

• W3121013252 endingPage "1132" @default.
• W3121013252 startingPage "1126" @default.
• W3121013252 abstract "Palliative treatment of bone metastasis using radiolabeled bisphosphonates is a well-known concept proven to be safe and effective. A new therapeutic radiopharmaceutical for bone metastasis is 177Lu-DOTA-zoledronic acid (177Lu-DOTA-ZOL). In this study, the safety and dosimetry of a single therapeutic dose of 177Lu-DOTA-ZOL were evaluated on the basis of a series of SPECT/CT images and blood samples. Methods: Nine patients with exclusive bone metastases from metastatic castration-resistant prostate cancer (mCRPC) (70.8 ± 8.4 y) and progression under conventional therapies participated in this prospective study. After receiving 5,780 ± 329 MBq 177Lu-DOTA-ZOL, patients underwent 3-dimensional whole-body SPECT/CT imaging and venous blood sampling over 7 d. Dosimetric evaluation was performed for main organs and tumor lesions. Safety was assessed by blood biomarkers. Results:177Lu-DOTA-ZOL showed fast uptake and high retention in bone lesions and fast clearance from the bloodstream in all patients. The average retention in tumor lesions was 0.02% injected activity per gram at 6 h after injection and approximately 0.01% at 170 h after injection. In this cohort, the average absorbed doses in bone tumor lesions, kidneys, red bone marrow, and bone surfaces were 4.21, 0.17, 0.36, and 1.19 Gy/GBq, respectively. The red marrow was found to be the dose-limiting organ for all patients. A median maximum tolerated injected activity of 6.0 GBq may exceed the defined threshold of 2 Gy for the red bone marrow in individual patients (4/8). Conclusion:177Lu-DOTA-ZOL is safe and has a favorable therapeutic index compared with other radiopharmaceuticals used in the treatment of osteoblastic bone metastases. Personalized dosimetry, however, should be considered to avoid severe hematotoxicity for individual patients." @default.
• W3121013252 created "2021-01-18" @default.
• W3121013252 creator A5001670517 @default.
• W3121013252 creator A5002458383 @default.
• W3121013252 creator A5007951232 @default.
• W3121013252 creator A5009773840 @default.
• W3121013252 creator A5015508507 @default.
• W3121013252 creator A5017251514 @default.
• W3121013252 creator A5024319650 @default.
• W3121013252 creator A5032408603 @default.
• W3121013252 creator A5040501350 @default.
• W3121013252 creator A5044613925 @default.
• W3121013252 creator A5050200817 @default.
• W3121013252 creator A5057321196 @default.
• W3121013252 creator A5060586728 @default.
• W3121013252 date "2021-01-08" @default.
• W3121013252 modified "2023-10-14" @default.
• W3121013252 title "Evaluation of Safety and Dosimetry of ¹⁷⁷Lu-DOTA-ZOL for Therapy of Bone Metastases" @default.
• W3121013252 cites W1140456871 @default.
• W3121013252 cites W1193303306 @default.
• W3121013252 cites W1497206380 @default.
• W3121013252 cites W1935514585 @default.
• W3121013252 cites W1946923111 @default.
• W3121013252 cites W1992701398 @default.
• W3121013252 cites W2020961166 @default.
• W3121013252 cites W2033952205 @default.
• W3121013252 cites W2049359866 @default.
• W3121013252 cites W2063402733 @default.
• W3121013252 cites W2069386429 @default.
• W3121013252 cites W2084453224 @default.
• W3121013252 cites W2092681716 @default.
• W3121013252 cites W2097512974 @default.
• W3121013252 cites W2132310957 @default.
• W3121013252 cites W2145938281 @default.
• W3121013252 cites W2154289925 @default.
• W3121013252 cites W2159724788 @default.
• W3121013252 cites W2166646070 @default.
• W3121013252 cites W2185903192 @default.
• W3121013252 cites W2224590261 @default.
• W3121013252 cites W2266547198 @default.
• W3121013252 cites W2292690906 @default.
• W3121013252 cites W2302508993 @default.
• W3121013252 cites W2522974244 @default.
• W3121013252 cites W2611138714 @default.
• W3121013252 cites W2615849101 @default.
• W3121013252 cites W2728449452 @default.
• W3121013252 cites W2766416509 @default.
• W3121013252 cites W2799578330 @default.
• W3121013252 cites W2807494087 @default.
• W3121013252 cites W2921986565 @default.
• W3121013252 cites W2990979064 @default.
• W3121013252 cites W4205384219 @default.
• W3121013252 cites W4245106658 @default.
• W3121013252 cites W4291181444 @default.
• W3121013252 doi "https://doi.org/10.2967/jnumed.120.255851" @default.
• W3121013252 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33419945" @default.
• W3121013252 hasPublicationYear "2021" @default.
• W3121013252 type Work @default.
• W3121013252 sameAs 3121013252 @default.
• W3121013252 citedByCount "14" @default.
• W3121013252 countsByYear W31210132522021 @default.
• W3121013252 countsByYear W31210132522022 @default.
• W3121013252 countsByYear W31210132522023 @default.
• W3121013252 crossrefType "journal-article" @default.
• W3121013252 hasAuthorship W3121013252A5001670517 @default.
• W3121013252 hasAuthorship W3121013252A5002458383 @default.
• W3121013252 hasAuthorship W3121013252A5007951232 @default.
• W3121013252 hasAuthorship W3121013252A5009773840 @default.
• W3121013252 hasAuthorship W3121013252A5015508507 @default.
• W3121013252 hasAuthorship W3121013252A5017251514 @default.
• W3121013252 hasAuthorship W3121013252A5024319650 @default.
• W3121013252 hasAuthorship W3121013252A5032408603 @default.
• W3121013252 hasAuthorship W3121013252A5040501350 @default.
• W3121013252 hasAuthorship W3121013252A5044613925 @default.
• W3121013252 hasAuthorship W3121013252A5050200817 @default.
• W3121013252 hasAuthorship W3121013252A5057321196 @default.
• W3121013252 hasAuthorship W3121013252A5060586728 @default.
• W3121013252 hasBestOaLocation W31210132521 @default.
• W3121013252 hasConcept C121608353 @default.
• W3121013252 hasConcept C126322002 @default.
• W3121013252 hasConcept C126838900 @default.
• W3121013252 hasConcept C126894567 @default.
• W3121013252 hasConcept C150903083 @default.
• W3121013252 hasConcept C207001950 @default.
• W3121013252 hasConcept C2776049877 @default.
• W3121013252 hasConcept C2777783956 @default.
• W3121013252 hasConcept C2779931791 @default.
• W3121013252 hasConcept C2780007613 @default.
• W3121013252 hasConcept C2780192828 @default.
• W3121013252 hasConcept C2989005 @default.
• W3121013252 hasConcept C2993559085 @default.
• W3121013252 hasConcept C71924100 @default.
• W3121013252 hasConcept C75088862 @default.
• W3121013252 hasConcept C86803240 @default.
• W3121013252 hasConceptScore W3121013252C121608353 @default.
• W3121013252 hasConceptScore W3121013252C126322002 @default.
• W3121013252 hasConceptScore W3121013252C126838900 @default.
• W3121013252 hasConceptScore W3121013252C126894567 @default.

• next