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• W3121036749 abstract "Some subtypes of acute myeloid leukemia (AML) share morphologic, immunophenotypic, and clinical features of acute promyelocytic leukemia (APL), but lack a PML–RARA (promyelocytic leukemia–retinoic acid receptor alpha) fusion gene. Instead, they have the retinoic acid receptor beta (RARB) or retinoic acid receptor gamma (RARG) rearranged. Almost all of these AML subtypes exhibit resistance to all-trans retinoic acid (ATRA); undoubtedly, the prognosis is poor. Here, we present an AML patient resembling APL with a novel cleavage and polyadenylation specific factor 6 ( CPSF6) –RARG fusion, showing resistance to ATRA and poor response to chemotherapy with homoharringtonine and cytarabine. Simultaneously, the patient also had extramedullary infiltration." @default.
• W3121036749 created "2021-01-18" @default.
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• W3121036749 date "2021-01-01" @default.
• W3121036749 modified "2023-09-24" @default.
• W3121036749 title "Acute myeloid leukemia with CPSF6–RARG fusion resembling acute promyelocytic leukemia with extramedullary infiltration" @default.
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• W3121036749 doi "https://doi.org/10.1177/2040620720976984" @default.
• W3121036749 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7797573" @default.
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