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- W3121049875 abstract "Target of rapamycin complex 1 (TORC1), a serine/threonine-protein kinase complex highly conserved among eukaryotes, coordinates cellular growth and metabolism with environmental cues, including nutrients and growth factors. Aberrant TORC1 signaling is associated with cancers and various human diseases, and TORC1 also plays a key role in ageing and lifespan, urging current active research on the mechanisms of TORC1 regulation in a variety of model organisms. Identification and characterization of the RAG small GTPases as well as their regulators, many of which are highly conserved from yeast to humans, led to a series of breakthroughs in understanding the molecular bases of TORC1 regulation. Recruitment of mammalian TORC1 (mTORC1) by RAGs to lysosomal membranes is a key step for mTORC1 activation. Interestingly, the RAG GTPases in fission yeast are primarily responsible for attenuation of TORC1 activity on vacuoles, the yeast equivalent of lysosomes. In this review, we summarize our current knowledge about the functions of TORC1 regulators on yeast vacuoles, and illustrate the conserved and divergent mechanisms of TORC1 regulation between yeasts and mammals." @default.
- W3121049875 created "2021-01-18" @default.
- W3121049875 creator A5009755106 @default.
- W3121049875 creator A5062893396 @default.
- W3121049875 date "2021-01-12" @default.
- W3121049875 modified "2023-10-12" @default.
- W3121049875 title "Conserved and Divergent Mechanisms That Control TORC1 in Yeasts and Mammals" @default.
- W3121049875 cites W1496559643 @default.
- W3121049875 cites W1804602290 @default.
- W3121049875 cites W1877343178 @default.
- W3121049875 cites W1923022109 @default.
- W3121049875 cites W1967588638 @default.
- W3121049875 cites W1970870266 @default.
- W3121049875 cites W1971597300 @default.
- W3121049875 cites W1972718290 @default.
- W3121049875 cites W1981206208 @default.
- W3121049875 cites W1982985819 @default.
- W3121049875 cites W1984000730 @default.
- W3121049875 cites W1985754630 @default.
- W3121049875 cites W1990960113 @default.
- W3121049875 cites W1992987381 @default.
- W3121049875 cites W1995455069 @default.
- W3121049875 cites W2001794548 @default.
- W3121049875 cites W2002031023 @default.
- W3121049875 cites W2006559495 @default.
- W3121049875 cites W2008139538 @default.
- W3121049875 cites W2017058729 @default.
- W3121049875 cites W2021660402 @default.
- W3121049875 cites W2023012828 @default.
- W3121049875 cites W2025176940 @default.
- W3121049875 cites W2025227520 @default.
- W3121049875 cites W2027785297 @default.
- W3121049875 cites W2031738820 @default.
- W3121049875 cites W2045016256 @default.
- W3121049875 cites W2051964904 @default.
- W3121049875 cites W2052501713 @default.
- W3121049875 cites W2053521831 @default.
- W3121049875 cites W2054591128 @default.
- W3121049875 cites W2056137479 @default.
- W3121049875 cites W2056735058 @default.
- W3121049875 cites W2057106513 @default.
- W3121049875 cites W2060607801 @default.
- W3121049875 cites W2063013559 @default.
- W3121049875 cites W2065700634 @default.
- W3121049875 cites W2067109110 @default.
- W3121049875 cites W2067673948 @default.
- W3121049875 cites W2076568661 @default.
- W3121049875 cites W2083087851 @default.
- W3121049875 cites W2083390185 @default.
- W3121049875 cites W2084712051 @default.
- W3121049875 cites W2086292277 @default.
- W3121049875 cites W2087136249 @default.
- W3121049875 cites W2089632625 @default.
- W3121049875 cites W2093154482 @default.
- W3121049875 cites W2093359582 @default.
- W3121049875 cites W2094517081 @default.
- W3121049875 cites W2101083009 @default.
- W3121049875 cites W2103711397 @default.
- W3121049875 cites W2104316079 @default.
- W3121049875 cites W2106043035 @default.
- W3121049875 cites W2109263914 @default.
- W3121049875 cites W2114859236 @default.
- W3121049875 cites W2117994966 @default.
- W3121049875 cites W2119385226 @default.
- W3121049875 cites W2120356140 @default.
- W3121049875 cites W2121211842 @default.
- W3121049875 cites W2127063807 @default.
- W3121049875 cites W2134138119 @default.
- W3121049875 cites W2136676465 @default.
- W3121049875 cites W2137372494 @default.
- W3121049875 cites W2139856846 @default.
- W3121049875 cites W2144059623 @default.
- W3121049875 cites W2145272227 @default.
- W3121049875 cites W2147544249 @default.
- W3121049875 cites W2152600551 @default.
- W3121049875 cites W2158328061 @default.
- W3121049875 cites W2158612356 @default.
- W3121049875 cites W2159287589 @default.
- W3121049875 cites W2159398725 @default.
- W3121049875 cites W2160699729 @default.
- W3121049875 cites W2170633329 @default.
- W3121049875 cites W2257158960 @default.
- W3121049875 cites W2257572427 @default.
- W3121049875 cites W2261179472 @default.
- W3121049875 cites W2289705132 @default.
- W3121049875 cites W2408048718 @default.
- W3121049875 cites W2576890255 @default.
- W3121049875 cites W2588791993 @default.
- W3121049875 cites W2588948554 @default.
- W3121049875 cites W2593816418 @default.
- W3121049875 cites W2611963968 @default.
- W3121049875 cites W2613182586 @default.
- W3121049875 cites W2757150230 @default.
- W3121049875 cites W2761743895 @default.
- W3121049875 cites W2763844770 @default.
- W3121049875 cites W2765487476 @default.
- W3121049875 cites W2767139423 @default.
- W3121049875 cites W2768374432 @default.