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• W3121058933 abstract "Purpose: This study investigated the possible uroprotective effects of Hypericum triquetrifolium Turra. (HT) seed methanol extracts (25,50,100 mg/kg, i.p., for 6 days) against cyclophosphamide (CYP)-induced (150 mg/kg, single dose, i.p.) acute bladder hemorrhagic cystitis (HC) and nephrotoxicity in rats. &#x0D; Materials and Methods: Wistar albino rats used in this study were divided into nine groups, each including seven rats. Group 1 (control) was treated with 0.5ml saline (SF) and Group 2 was treated with CYP (150 mg/kg). Groups 3, 4, 5 were treated with 25, 50, 100 mg/kg HT, respectively while groups 6, 7, 8 were treated with 25, 50, 100 mg/kg CYP + HT, respectively. Finally, Group 9 (control-2) was treated with 0.5ml-%0.2 dimethyl sulfoxide (DMSO). The serum creatinine, blood urea nitrogen (BUN), superoxide dismutase (SOD) and catalase (CAT) levels were measured in blood serum. &#x0D; Results: The CYP-treated rats histopathologically had mild-moderate bladder and renal injuries. The serum creatinine and BUN levels, which are the biochemical markers of renal injury, significantly increased compared to the control group.&#x0D; Conclusion: HT showed a protective effect on CYP-related bladder HC and nephrotoxicity in rats by inhibiting inflammation and apoptosis." @default.
• W3121058933 created "2021-01-18" @default.
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• W3121058933 date "2020-12-27" @default.
• W3121058933 modified "2023-09-23" @default.
• W3121058933 title "Wistar albino sıçanlarında Hypericum triquetrifolium Turra. tohum metanol ekstraktlarının siklofosfamid-nedenli mesane hemorajik sistiti ve nefrotoksisitesi üzerine üroprotektif etkilerinin incelenmesi" @default.
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• W3121058933 doi "https://doi.org/10.17826/cumj.730817" @default.
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