FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121060165> ?p ?o ?g. }

• W3121060165 endingPage "885" @default.
• W3121060165 startingPage "877" @default.
• W3121060165 abstract "Benzopyrylium salts are an unexplored class of compounds and as a first, this study reports them as potential therapeutic agents. In this effort we pursue the synthesis and in vitro anticancer, antibacterial and antioxidant properties of some novel benzopyrylium salts. The benzopyrylium salts were synthesized and further characterized via UV-vis, IR, 1H-NMR, 13C-NMR and mass spectrometry. The benzopyrylium salts were tested in vitro for anticancer activity across NCI 60 cell line panel. PS-CP-4MO showed the best activity against the MDA-MB-435 cell line of melanoma cancer in terms of the least GI50 (1.78 µM), TGI (3.47 µM) and LC50 (6.77 µM) values and showed selectivity against melanoma, colon cancer and leukemia. Mechanistic studies indicate that this compound inhibits MCF-7 cancer cells by inducing apoptosis and abrogates colony formation and wound healing in the cancer cells. Antibacterial studies show that some of the benzopyrylium salts are active on S. aureus (ATCC 29213) and the best active compound PS-CP-5Cl has a MIC of 8 µg/mL. Antioxidant studies indicate that they have good free radical scavenging properties (PS-CP-5Cl showed activity 1.48 times ascorbic acid). Fulfillment of the Lipinski’s parameters of the benzopyrylium salts in silico showed tremendous drug likeness as potential pharmacophore leads." @default.
• W3121060165 created "2021-01-18" @default.
• W3121060165 creator A5022852554 @default.
• W3121060165 creator A5024407587 @default.
• W3121060165 creator A5031584638 @default.
• W3121060165 creator A5038262790 @default.
• W3121060165 creator A5047204018 @default.
• W3121060165 creator A5082576210 @default.
• W3121060165 date "2021-01-13" @default.
• W3121060165 modified "2023-10-16" @default.
• W3121060165 title "Benzopyrylium salts as new anticancer, antibacterial, and antioxidant agents" @default.
• W3121060165 cites W1579973977 @default.
• W3121060165 cites W1959156500 @default.
• W3121060165 cites W1981737096 @default.
• W3121060165 cites W2036081008 @default.
• W3121060165 cites W2048516127 @default.
• W3121060165 cites W2051078671 @default.
• W3121060165 cites W2083143554 @default.
• W3121060165 cites W2098399308 @default.
• W3121060165 cites W2110630189 @default.
• W3121060165 cites W2125314372 @default.
• W3121060165 cites W2155208683 @default.
• W3121060165 cites W2169576712 @default.
• W3121060165 cites W2951301441 @default.
• W3121060165 cites W2952099888 @default.
• W3121060165 cites W2952458885 @default.
• W3121060165 cites W4253168324 @default.
• W3121060165 doi "https://doi.org/10.1007/s00044-020-02685-3" @default.
• W3121060165 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/8443163" @default.
• W3121060165 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/34531644" @default.
• W3121060165 hasPublicationYear "2021" @default.
• W3121060165 type Work @default.
• W3121060165 sameAs 3121060165 @default.
• W3121060165 citedByCount "3" @default.
• W3121060165 countsByYear W31210601652022 @default.
• W3121060165 countsByYear W31210601652023 @default.
• W3121060165 crossrefType "journal-article" @default.
• W3121060165 hasAuthorship W3121060165A5022852554 @default.
• W3121060165 hasAuthorship W3121060165A5024407587 @default.
• W3121060165 hasAuthorship W3121060165A5031584638 @default.
• W3121060165 hasAuthorship W3121060165A5038262790 @default.
• W3121060165 hasAuthorship W3121060165A5047204018 @default.
• W3121060165 hasAuthorship W3121060165A5082576210 @default.
• W3121060165 hasBestOaLocation W31210601652 @default.
• W3121060165 hasConcept C113253001 @default.
• W3121060165 hasConcept C121608353 @default.
• W3121060165 hasConcept C126322002 @default.
• W3121060165 hasConcept C181199279 @default.
• W3121060165 hasConcept C185592680 @default.
• W3121060165 hasConcept C190283241 @default.
• W3121060165 hasConcept C202751555 @default.
• W3121060165 hasConcept C21951064 @default.
• W3121060165 hasConcept C2778004101 @default.
• W3121060165 hasConcept C2780104969 @default.
• W3121060165 hasConcept C2986274086 @default.
• W3121060165 hasConcept C31903555 @default.
• W3121060165 hasConcept C523546767 @default.
• W3121060165 hasConcept C54355233 @default.
• W3121060165 hasConcept C55493867 @default.
• W3121060165 hasConcept C56173144 @default.
• W3121060165 hasConcept C71240020 @default.
• W3121060165 hasConcept C71924100 @default.
• W3121060165 hasConcept C81885089 @default.
• W3121060165 hasConcept C86803240 @default.
• W3121060165 hasConcept C96232424 @default.
• W3121060165 hasConceptScore W3121060165C113253001 @default.
• W3121060165 hasConceptScore W3121060165C121608353 @default.
• W3121060165 hasConceptScore W3121060165C126322002 @default.
• W3121060165 hasConceptScore W3121060165C181199279 @default.
• W3121060165 hasConceptScore W3121060165C185592680 @default.
• W3121060165 hasConceptScore W3121060165C190283241 @default.
• W3121060165 hasConceptScore W3121060165C202751555 @default.
• W3121060165 hasConceptScore W3121060165C21951064 @default.
• W3121060165 hasConceptScore W3121060165C2778004101 @default.
• W3121060165 hasConceptScore W3121060165C2780104969 @default.
• W3121060165 hasConceptScore W3121060165C2986274086 @default.
• W3121060165 hasConceptScore W3121060165C31903555 @default.
• W3121060165 hasConceptScore W3121060165C523546767 @default.
• W3121060165 hasConceptScore W3121060165C54355233 @default.
• W3121060165 hasConceptScore W3121060165C55493867 @default.
• W3121060165 hasConceptScore W3121060165C56173144 @default.
• W3121060165 hasConceptScore W3121060165C71240020 @default.
• W3121060165 hasConceptScore W3121060165C71924100 @default.
• W3121060165 hasConceptScore W3121060165C81885089 @default.
• W3121060165 hasConceptScore W3121060165C86803240 @default.
• W3121060165 hasConceptScore W3121060165C96232424 @default.
• W3121060165 hasIssue "4" @default.
• W3121060165 hasLocation W31210601651 @default.
• W3121060165 hasLocation W31210601652 @default.
• W3121060165 hasLocation W31210601653 @default.
• W3121060165 hasOpenAccess W3121060165 @default.
• W3121060165 hasPrimaryLocation W31210601651 @default.
• W3121060165 hasRelatedWork W2054895265 @default.
• W3121060165 hasRelatedWork W2079665383 @default.
• W3121060165 hasRelatedWork W2350965768 @default.
• W3121060165 hasRelatedWork W2367589405 @default.
• W3121060165 hasRelatedWork W2387313479 @default.
• W3121060165 hasRelatedWork W2411104204 @default.

• next