Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121093989> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W3121093989 abstract "Background and Aims: Invasive pulmonary aspergillosis (IPA) is an imperative concern in the present era due to its high occurrence and mortality rate in severely immunocompromised patients. The present study was designed to develop, optimize and characterize encapsulated nystatin (NYS) cubosome nanoparticles as an inhalable system, a viable alternative for effective management of IPA. Methods: A dry lipidic film comprising glycerol monooleate (GMO), Span 83, Poloxamer (P-407) and dispersed NYS was subjected to ultrasound sonication to produce colloidal dispersion of cubosomes. The process and formulation variables were screened using Plackett Burman design and further optimized by Box Behnken design by evaluating its effect on particle size, polydispersity index (PDI), zeta potential and entrapment efficiency. Results: The optimized NYS cubosomes were nearly spherical with some irregular polyangular symmetry as visualized by transmission electron microscopy (TEM). Further, small angle X-ray scattering (SAXS) affirmed Pn3m cubic mesophasic structure. The optimized nanoparticles had particle size 263.5 nm, zeta potential -14.4 mV, PDI 0.283 and entrapment efficiency 82%. The in-vitro cytotoxicity assay indicated that NYS cubosomes reduced cell cytotoxicity in contrast to pure drug post 48h. In-vitro haemolytic assay denoted lower toxicity of formulation as compared to free drug. In-vitro drug release studies highlighted, slow but continuous release from NYS cubosomes until 48h and showcased Higuchi release kinetics. Likewise, NYS cubosome demonstrated higher antifungal activity compared to drug suspended in phosphate buffer. Conclusion: Thus, non-invasive feature and contemplated target specificity of nystatin loaded cubosome nanoparticles pave a mode for its prospect as pulmonary delivery to combat IPA." @default.
- W3121093989 created "2021-01-18" @default.
- W3121093989 creator A5023578720 @default.
- W3121093989 creator A5063332322 @default.
- W3121093989 date "2020-12-30" @default.
- W3121093989 modified "2023-10-15" @default.
- W3121093989 title "Development of inhalable cubosome nanoparticles of Nystatin for effective management of Invasive Pulmonary Aspergillosis" @default.
- W3121093989 doi "https://doi.org/10.26650/istanbuljpharm.2020.0006" @default.
- W3121093989 hasPublicationYear "2020" @default.
- W3121093989 type Work @default.
- W3121093989 sameAs 3121093989 @default.
- W3121093989 citedByCount "0" @default.
- W3121093989 crossrefType "journal-article" @default.
- W3121093989 hasAuthorship W3121093989A5023578720 @default.
- W3121093989 hasAuthorship W3121093989A5063332322 @default.
- W3121093989 hasBestOaLocation W31210939891 @default.
- W3121093989 hasConcept C104628117 @default.
- W3121093989 hasConcept C109316439 @default.
- W3121093989 hasConcept C11432220 @default.
- W3121093989 hasConcept C14631669 @default.
- W3121093989 hasConcept C147789679 @default.
- W3121093989 hasConcept C155672457 @default.
- W3121093989 hasConcept C171250308 @default.
- W3121093989 hasConcept C178790620 @default.
- W3121093989 hasConcept C185592680 @default.
- W3121093989 hasConcept C187530423 @default.
- W3121093989 hasConcept C192562407 @default.
- W3121093989 hasConcept C202751555 @default.
- W3121093989 hasConcept C2777762789 @default.
- W3121093989 hasConcept C2779820397 @default.
- W3121093989 hasConcept C43617362 @default.
- W3121093989 hasConcept C501593827 @default.
- W3121093989 hasConcept C55493867 @default.
- W3121093989 hasConcept C58226133 @default.
- W3121093989 hasConcept C86181022 @default.
- W3121093989 hasConceptScore W3121093989C104628117 @default.
- W3121093989 hasConceptScore W3121093989C109316439 @default.
- W3121093989 hasConceptScore W3121093989C11432220 @default.
- W3121093989 hasConceptScore W3121093989C14631669 @default.
- W3121093989 hasConceptScore W3121093989C147789679 @default.
- W3121093989 hasConceptScore W3121093989C155672457 @default.
- W3121093989 hasConceptScore W3121093989C171250308 @default.
- W3121093989 hasConceptScore W3121093989C178790620 @default.
- W3121093989 hasConceptScore W3121093989C185592680 @default.
- W3121093989 hasConceptScore W3121093989C187530423 @default.
- W3121093989 hasConceptScore W3121093989C192562407 @default.
- W3121093989 hasConceptScore W3121093989C202751555 @default.
- W3121093989 hasConceptScore W3121093989C2777762789 @default.
- W3121093989 hasConceptScore W3121093989C2779820397 @default.
- W3121093989 hasConceptScore W3121093989C43617362 @default.
- W3121093989 hasConceptScore W3121093989C501593827 @default.
- W3121093989 hasConceptScore W3121093989C55493867 @default.
- W3121093989 hasConceptScore W3121093989C58226133 @default.
- W3121093989 hasConceptScore W3121093989C86181022 @default.
- W3121093989 hasIssue "3" @default.
- W3121093989 hasLocation W31210939891 @default.
- W3121093989 hasLocation W31210939892 @default.
- W3121093989 hasOpenAccess W3121093989 @default.
- W3121093989 hasPrimaryLocation W31210939891 @default.
- W3121093989 hasRelatedWork W116530136 @default.
- W3121093989 hasRelatedWork W1981861511 @default.
- W3121093989 hasRelatedWork W2140907237 @default.
- W3121093989 hasRelatedWork W2203584037 @default.
- W3121093989 hasRelatedWork W2502831949 @default.
- W3121093989 hasRelatedWork W3056888011 @default.
- W3121093989 hasRelatedWork W3097648928 @default.
- W3121093989 hasRelatedWork W3170578903 @default.
- W3121093989 hasRelatedWork W4205624080 @default.
- W3121093989 hasRelatedWork W4220854007 @default.
- W3121093989 hasVolume "50" @default.
- W3121093989 isParatext "false" @default.
- W3121093989 isRetracted "false" @default.
- W3121093989 magId "3121093989" @default.
- W3121093989 workType "article" @default.