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• W3121096135 endingPage "102354" @default.
• W3121096135 startingPage "102354" @default.
• W3121096135 abstract "Diagnosis and treatment of breast cancer in pregnancy can result in morbidity and mortality for the mother and fetus. Many new paclitaxel nanoformulations commercially available worldwide for breast cancer treatment are being adopted due to favorable dosing regimens and side effect profiles, but their transplacental transport and resultant fetal exposure remain unknown. Here, we examine three formulations: Taxol (paclitaxel dissolved in Kolliphor EL and ethanol); Abraxane (albumin nanoparticle); and Genexol-PM (polymeric micelle). In the ex vivo dually perfused human placental cotyledon, placental accumulation of Genexol-PM is higher than Taxol, and both nanoformulations have lower maternal concentrations of paclitaxel over time. In vitro studies of these formulations and fluorescent nanoparticle analogs demonstrate that Genexol-PM allows paclitaxel to overcome P-glycoprotein efflux, but Abraxane behaves as a free drug formulation. We anticipate that these findings will impact future development of rational and safe treatment strategies for pregnancy-associated breast cancer and other diseases." @default.
• W3121096135 created "2021-01-18" @default.
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• W3121096135 date "2021-04-01" @default.
• W3121096135 modified "2023-10-17" @default.
• W3121096135 title "Formulation effects on paclitaxel transfer and uptake in the human placenta" @default.
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• W3121096135 doi "https://doi.org/10.1016/j.nano.2020.102354" @default.
• W3121096135 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33429062" @default.
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