FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3121098183> ?p ?o ?g. }

• W3121098183 endingPage "14" @default.
• W3121098183 startingPage "5" @default.
• W3121098183 abstract "Abstract The conventional perception asserts that immunology is the science of ‘discrimination’ between self and non-self. This concept is however no longer tenable as effector cells of the adaptive immune system are first conditioned to be tolerant to the body’s own antigens, collectively known as self until now. Only then attain these effectors the responsiveness to non-self. The acquisition of this essential state of tolerance to self occurs for T cells in the thymus, the last major organ of our body that revealed its intricate function in health and disease. The ‘thymus’ as an anatomical notion was first notably documented in Ancient Greece although our present understanding of the organ’s functions was only deciphered commencing in the 1960s. In the late 1980s, the thymus was identified as the site where clones of cells reactive to self, termed ‘forbidden’ thymocytes, are physically depleted as the result of a process now known as negative selection. The recognition of this mechanism further contributed to the belief that the central rationale of immunology as a science lies in the distinction between self and non-self. This review will discuss the evidence that the thymus serves as a unique lymphoid organ able to instruct T cells to recognize and be tolerant to harmless self before adopting the capacity to defend the body against potentially injurious non-self-antigens presented in the context of different challenges from infections to exposure to malignant cells. The emerging insight into the thymus’ cardinal functions now also provides an opportunity to exploit this knowledge to develop novel strategies that specifically prevent or even treat organ-specific autoimmune diseases." @default.
• W3121098183 created "2021-01-18" @default.
• W3121098183 creator A5047685038 @default.
• W3121098183 date "2021-01-07" @default.
• W3121098183 modified "2023-10-02" @default.
• W3121098183 title "The thymus and the science of self" @default.
• W3121098183 cites W1521887094 @default.
• W3121098183 cites W1555988808 @default.
• W3121098183 cites W1967281124 @default.
• W3121098183 cites W1968492161 @default.
• W3121098183 cites W1977774863 @default.
• W3121098183 cites W1978980578 @default.
• W3121098183 cites W1980133038 @default.
• W3121098183 cites W1990395260 @default.
• W3121098183 cites W1992964878 @default.
• W3121098183 cites W2001621054 @default.
• W3121098183 cites W2005350058 @default.
• W3121098183 cites W2007362831 @default.
• W3121098183 cites W2007608493 @default.
• W3121098183 cites W2008356343 @default.
• W3121098183 cites W2015941944 @default.
• W3121098183 cites W2017579442 @default.
• W3121098183 cites W2017875140 @default.
• W3121098183 cites W2025950097 @default.
• W3121098183 cites W2026468137 @default.
• W3121098183 cites W2026891958 @default.
• W3121098183 cites W2028222510 @default.
• W3121098183 cites W2031897773 @default.
• W3121098183 cites W2038623489 @default.
• W3121098183 cites W2046052383 @default.
• W3121098183 cites W2047784036 @default.
• W3121098183 cites W2050101274 @default.
• W3121098183 cites W2058933354 @default.
• W3121098183 cites W2061804435 @default.
• W3121098183 cites W2065481027 @default.
• W3121098183 cites W2067747103 @default.
• W3121098183 cites W2071591718 @default.
• W3121098183 cites W2075367960 @default.
• W3121098183 cites W2079642342 @default.
• W3121098183 cites W2079826943 @default.
• W3121098183 cites W2083737302 @default.
• W3121098183 cites W2085866455 @default.
• W3121098183 cites W2086764321 @default.
• W3121098183 cites W2088691398 @default.
• W3121098183 cites W2098838729 @default.
• W3121098183 cites W2099298895 @default.
• W3121098183 cites W2100521539 @default.
• W3121098183 cites W2102807926 @default.
• W3121098183 cites W2103712017 @default.
• W3121098183 cites W2105199763 @default.
• W3121098183 cites W2114374730 @default.
• W3121098183 cites W2116563291 @default.
• W3121098183 cites W2118803516 @default.
• W3121098183 cites W2119002645 @default.
• W3121098183 cites W2119784820 @default.
• W3121098183 cites W2120164411 @default.
• W3121098183 cites W2121733174 @default.
• W3121098183 cites W2122634910 @default.
• W3121098183 cites W2125216037 @default.
• W3121098183 cites W2126278946 @default.
• W3121098183 cites W2132003377 @default.
• W3121098183 cites W2138319166 @default.
• W3121098183 cites W2140442507 @default.
• W3121098183 cites W2141649011 @default.
• W3121098183 cites W2146170336 @default.
• W3121098183 cites W2153518972 @default.
• W3121098183 cites W2153786188 @default.
• W3121098183 cites W2154866878 @default.
• W3121098183 cites W2160435000 @default.
• W3121098183 cites W2162058869 @default.
• W3121098183 cites W2165214298 @default.
• W3121098183 cites W2168161193 @default.
• W3121098183 cites W2169633465 @default.
• W3121098183 cites W2170236060 @default.
• W3121098183 cites W2890493427 @default.
• W3121098183 cites W2917646500 @default.
• W3121098183 cites W2941033372 @default.
• W3121098183 cites W3035486810 @default.
• W3121098183 cites W3037980029 @default.
• W3121098183 cites W3083864090 @default.
• W3121098183 doi "https://doi.org/10.1007/s00281-020-00831-y" @default.
• W3121098183 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/7925502" @default.
• W3121098183 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/33415360" @default.
• W3121098183 hasPublicationYear "2021" @default.
• W3121098183 type Work @default.
• W3121098183 sameAs 3121098183 @default.
• W3121098183 citedByCount "14" @default.
• W3121098183 countsByYear W31210981832021 @default.
• W3121098183 countsByYear W31210981832022 @default.
• W3121098183 countsByYear W31210981832023 @default.
• W3121098183 crossrefType "journal-article" @default.
• W3121098183 hasAuthorship W3121098183A5047685038 @default.
• W3121098183 hasBestOaLocation W31210981831 @default.
• W3121098183 hasConcept C14036430 @default.
• W3121098183 hasConcept C151730666 @default.
• W3121098183 hasConcept C193419808 @default.
• W3121098183 hasConcept C203014093 @default.
• W3121098183 hasConcept C2776090121 @default.

• next