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- W3121105734 abstract "Abstract Background Over the past few years, prescriptions of antipsychotic medications have risen significantly. In particular, there is increasing use of second- and third-generation antipsychotic agents. However, numerous studies have shown clinically relevant adverse effects (such as weight gain, metabolic disorders, prolactin changes, and extrapyramidal symptoms [EPS]) with these therapeutic agents. The objective of this article is to provide a comparative review of the safety data available for antipsychotic drug use. Methods review the available literatures and case studies done on the neuro-endocrinal effects of the antipsychotics for the past 20 years from the following database: libraries of faculties of medicine of various Egyptian universities and database of various journals of psychiatry and through Pubmed and Scopus search engines. Limitations Absence of Arabic studies. Shortage of modern references. Conclusions Atypical antipsychotics are thought to be safer than typical antipsychotics, so they are the first-line of treatment at first-episode of psychosis, at least in the short-term. But, atypical antipsychotics still have severe neuro-endocrinal side effects. Each drug should be considered according to their suited to the patient. To avoid the side effects, choose the suitable antipsychotic drug, use the lowest efficatious dose; the minimum dose and duration of treatment, have good communication with the patients about the side effects to treat them immediately when they appear and to stop the medication." @default.
- W3121105734 created "2021-01-18" @default.
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- W3121105734 date "2020-03-01" @default.
- W3121105734 modified "2023-09-27" @default.
- W3121105734 title "Neuro-endocrinal effects of antipsychotics" @default.
- W3121105734 doi "https://doi.org/10.1093/qjmed/hcaa054.001" @default.
- W3121105734 hasPublicationYear "2020" @default.
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