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- W3121110678 endingPage "63" @default.
- W3121110678 startingPage "63" @default.
- W3121110678 abstract "Cell plasma membrane proteins are considered as gatekeepers of the cell and play a major role in regulating various processes. Transport proteins constitute a subclass of cell plasma membrane proteins enabling the exchange of molecules and ions between the extracellular environment and the cytosol. A plethora of human pathologies are associated with the altered expression or dysfunction of cell plasma membrane transport proteins, making them interesting therapeutic drug targets. However, the search for therapeutics is challenging, since many drug candidates targeting cell plasma membrane proteins fail in (pre)clinical testing due to inadequate selectivity, specificity, potency or stability. These latter characteristics are met by nanobodies, which potentially renders them eligible therapeutics targeting cell plasma membrane proteins. Therefore, a therapeutic nanobody-based strategy seems a valid approach to target and modulate the activity of cell plasma membrane transport proteins. This review paper focuses on methodologies to generate cell plasma membrane transport protein-targeting nanobodies, and the advantages and pitfalls while generating these small antibody-derivatives, and discusses several therapeutic nanobodies directed towards transmembrane proteins, including channels and pores, adenosine triphosphate-powered pumps and porters." @default.
- W3121110678 created "2021-01-18" @default.
- W3121110678 creator A5023971009 @default.
- W3121110678 creator A5041691799 @default.
- W3121110678 creator A5045862213 @default.
- W3121110678 creator A5067597833 @default.
- W3121110678 creator A5086007558 @default.
- W3121110678 date "2021-01-06" @default.
- W3121110678 modified "2023-10-01" @default.
- W3121110678 title "Therapeutic Nanobodies Targeting Cell Plasma Membrane Transport Proteins: A High-Risk/High-Gain Endeavor" @default.
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