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- W3121116250 abstract "Peripheral artery disease is caused by atherosclerosis of lower extremity arteries leading to the loss of blood perfusion and subsequent critical ischemia. The presence of diabetes mellitus is an important risk factor that greatly increases the incidence, the progression and the severity of the disease. In addition to accelerated disease progression, diabetic patients are also more susceptible to develop serious impairment of their walking abilities through an increased risk of lower limb amputation. Hyperglycemia is known to alter the physiological development of collateral arteries in response to ischemia. Deregulation in the production of several critical pro-angiogenic factors has been reported in diabetes along with vascular cell unresponsiveness in initiating angiogenic processes. Among the multiple molecular mechanisms involved in the angiogenic response, protein tyrosine phosphatases are potent regulators by dephosphorylating pro-angiogenic tyrosine kinase receptors. However, evidence has indicated that diabetes-induced deregulation of phosphatases contributes to the progression of several micro and macrovascular complications. This review provides an overview of growth factor alterations in the context of diabetes and peripheral artery disease, as well as a description of the role of phosphatases in the regulation of angiogenic pathways followed by an analysis of the effects of hyperglycemia on the modulation of protein tyrosine phosphatase expression and activity. Knowledge of the role of phosphatases in diabetic peripheral artery disease will help the development of future therapeutics to locally regulate phosphatases and improve angiogenesis." @default.
- W3121116250 created "2021-01-18" @default.
- W3121116250 creator A5000701833 @default.
- W3121116250 creator A5059834060 @default.
- W3121116250 creator A5079045178 @default.
- W3121116250 date "2021-01-07" @default.
- W3121116250 modified "2023-10-11" @default.
- W3121116250 title "Growth Factor Deregulation and Emerging Role of Phosphatases in Diabetic Peripheral Artery Disease" @default.
- W3121116250 cites W1495287184 @default.
- W3121116250 cites W1566234231 @default.
- W3121116250 cites W1590990620 @default.
- W3121116250 cites W1792519461 @default.
- W3121116250 cites W1956236579 @default.
- W3121116250 cites W1965103387 @default.
- W3121116250 cites W1966263926 @default.
- W3121116250 cites W1968379544 @default.
- W3121116250 cites W1973465872 @default.
- W3121116250 cites W1973838029 @default.
- W3121116250 cites W1982085952 @default.
- W3121116250 cites W1982152757 @default.
- W3121116250 cites W1985125414 @default.
- W3121116250 cites W1985222413 @default.
- W3121116250 cites W1985498796 @default.
- W3121116250 cites W1991857601 @default.
- W3121116250 cites W1993601219 @default.
- W3121116250 cites W1993948601 @default.
- W3121116250 cites W1995212065 @default.
- W3121116250 cites W1997113481 @default.
- W3121116250 cites W1997143297 @default.
- W3121116250 cites W2000985210 @default.
- W3121116250 cites W2001148317 @default.
- W3121116250 cites W2001546419 @default.
- W3121116250 cites W2007883695 @default.
- W3121116250 cites W2009009599 @default.
- W3121116250 cites W2012825701 @default.
- W3121116250 cites W2013927550 @default.
- W3121116250 cites W2014179250 @default.
- W3121116250 cites W2015323647 @default.
- W3121116250 cites W2017832434 @default.
- W3121116250 cites W2019182002 @default.
- W3121116250 cites W2023423740 @default.
- W3121116250 cites W2027803752 @default.
- W3121116250 cites W2030135968 @default.
- W3121116250 cites W2030815783 @default.
- W3121116250 cites W2035067137 @default.
- W3121116250 cites W2038613657 @default.
- W3121116250 cites W2039210536 @default.
- W3121116250 cites W2042761977 @default.
- W3121116250 cites W2044987100 @default.
- W3121116250 cites W2045530731 @default.
- W3121116250 cites W2048132767 @default.
- W3121116250 cites W2052878767 @default.
- W3121116250 cites W2053551217 @default.
- W3121116250 cites W2056752509 @default.
- W3121116250 cites W2056895037 @default.
- W3121116250 cites W2064088110 @default.
- W3121116250 cites W2064371327 @default.
- W3121116250 cites W2064784101 @default.
- W3121116250 cites W2066877588 @default.
- W3121116250 cites W2071522285 @default.
- W3121116250 cites W2074744375 @default.
- W3121116250 cites W2077661851 @default.
- W3121116250 cites W2078083828 @default.
- W3121116250 cites W2078892596 @default.
- W3121116250 cites W2081872783 @default.
- W3121116250 cites W2083714459 @default.
- W3121116250 cites W2085007657 @default.
- W3121116250 cites W2088458569 @default.
- W3121116250 cites W2092364629 @default.
- W3121116250 cites W2096415262 @default.
- W3121116250 cites W2096486016 @default.
- W3121116250 cites W2097710619 @default.
- W3121116250 cites W2098432607 @default.
- W3121116250 cites W2100393793 @default.
- W3121116250 cites W2100425244 @default.
- W3121116250 cites W2102478648 @default.
- W3121116250 cites W2106922182 @default.
- W3121116250 cites W2107016439 @default.
- W3121116250 cites W2108202432 @default.
- W3121116250 cites W2108332586 @default.
- W3121116250 cites W2112715147 @default.
- W3121116250 cites W2117540279 @default.
- W3121116250 cites W2120953129 @default.
- W3121116250 cites W2123229219 @default.
- W3121116250 cites W2124720400 @default.
- W3121116250 cites W2125163614 @default.
- W3121116250 cites W2126945510 @default.
- W3121116250 cites W2130335364 @default.
- W3121116250 cites W2131160537 @default.
- W3121116250 cites W2133029597 @default.
- W3121116250 cites W2135110123 @default.
- W3121116250 cites W2135268790 @default.
- W3121116250 cites W2135849415 @default.
- W3121116250 cites W2138274682 @default.
- W3121116250 cites W2141030428 @default.
- W3121116250 cites W2142041241 @default.
- W3121116250 cites W2143035153 @default.
- W3121116250 cites W2144401190 @default.
- W3121116250 cites W2147772037 @default.
- W3121116250 cites W2148286539 @default.